{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:42:06Z","timestamp":1791996126422,"version":"4.4.0"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geburtshilfe Frauenheilkd"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose The aim was to develop and update a guideline which would improve the quality of care offered to women with gestational and non-gestational trophoblastic disease, a group of\n          diseases characterized by their rarity and biological heterogeneity.<\/jats:p><jats:p>\n          Methods In accordance with the method used to compile S2k-guidelines, the guideline authors carried out a search of the literature (MEDLINE) for the period 1\/2020 to 12\/2021 and\n          evaluated the recent literature. No key questions were formulated. No structured literature search with methodical evaluation and assessment of the level of evidence was carried out. The\n          text of the precursor version of the guideline from 2019 was updated based on the most recent literature, and new statements and recommendations were drafted.<\/jats:p><jats:p>\n          Recommendations The updated guideline contains recommendations for the diagnosis and therapy of women with hydatidiform mole (partial and complete moles), gestational trophoblastic\n          neoplasia after pregnancy or without prior pregnancy, persistent trophoblastic disease after molar pregnancy, invasive moles, choriocarcinoma, placental site nodules, placental site\n          trophoblastic tumor, hyperplasia at the implantation site und epithelioid trophoblastic tumor. Separate chapters cover the determination and assessment of human chorionic gonadotropin (hCG),\n          histopathological evaluation of specimens, and the appropriate molecular pathological and immunohistochemical diagnostic procedures. Separate chapters on immunotherapy, surgical therapy,\n          multiple pregnancies with simultaneous trophoblastic disease, and pregnancy after trophoblastic disease were formulated, and the corresponding recommendations agreed upon.<\/jats:p>","DOI":"10.1055\/a-1904-6461","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T23:59:07Z","timestamp":1678406347000},"page":"267-288","source":"Crossref","is-referenced-by-count":4,"title":["Gestational and Non-gestational Trophoblastic Neoplasia. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No.\u2009032\/049, April 2022)"],"prefix":"10.1055","volume":"83","author":[{"given":"Clemens","family":"Tempfer","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsfrauenklinik der Ruhr-Universit\u00e4t Bochum, Marienhospital Herne, Bochum\/Herne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars-Christian","family":"Horn","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pathologie, Universit\u00e4tsklinikum Leipzig, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Ackermann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Frauenheilkunde und Geburtshilfe, Klinikum Darmstadt, Darmstadt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Dittrich","sequence":"additional","affiliation":[{"name":"Frauenklinik, Universit\u00e4tsklinikum Erlangen, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Einenkel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Frauenheilkunde und Geburtshilfe, Sana-Kliniken Leipziger Land, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"G\u00fcnthert","sequence":"additional","affiliation":[{"name":"Gyn-Zentrum Luzern, Universit\u00e4t Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidemarie","family":"Haase","sequence":"additional","affiliation":[{"name":"Frauenselbsthilfe nach Krebs e.\u200aV., Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Kratzsch","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Laboratoriumsmedizin, Klinische Chemie und Molekulare Diagnostik, Universit\u00e4tsklinikum Leipzig, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Krei\u00dfl","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Radiologie und Nuklearmedizin, Klinikum Magdeburg, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Polterauer","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsfrauenklinik, Medizinische Universit\u00e4t Wien, Wien, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Ebert","sequence":"additional","affiliation":[{"name":"Praxis f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Steiner","sequence":"additional","affiliation":[{"name":"Frauenklinik, GPR-Klinikum R\u00fcsselsheim, R\u00fcsselsheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk","family":"Thiel","sequence":"additional","affiliation":[{"name":"Frauenklinik, Klinik am Eichert, G\u00f6ppingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Eichbaum","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Frauenheilkunde und Geburtshilfe, Helios Dr. Horst-Schmidt-Kliniken Wiesbaden, Wiesbaden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Fehm","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Frauenheilkunde, Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin C.","family":"Koch","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Ansbach, 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