{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:18Z","timestamp":1787004858861,"version":"build-2736575974"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>Objective\u2003The international consensus on continuous glucose monitoring (CGM) recommends time in range (TIR) target of &gt;70% for pregnant people. Our aim was to compare outcomes between pregnant people with TIR \u2264 versus &gt;70%.<\/jats:p>\n                  <jats:p>Study Design\u2003This study was a retrospective study of all people using CGM during pregnancy from January 2017 to May 2021 at a tertiary care center. All people with pregestational diabetes who used CGM and delivered at our center were included in the analysis. Primary neonatal outcome included any of the following: large for gestational age, neonatal intensive care unit (NICU) admission, need for intravenous (IV) glucose, or respiratory distress syndrome (RDS). Maternal outcomes included hypertensive disorders of pregnancy and delivery outcomes. Logistic regression was used to estimate unadjusted and adjusted odds ratios (aORs) with 95% confidence intervals (CIs).<\/jats:p>\n                  <jats:p>Results\u2003Of 78 people managed with CGM, 65 (80%) met inclusion criteria. While 33 people (50.1%) had TIR \u226470%, 32 (49.2%) had TIR &gt;70%. People with TIR \u226470% were more likely to be younger, have a lower body mass index, and have type 1 diabetes than those with TIR &gt;70%. After multivariable regression, there was no difference in the composite neonatal outcome between the groups (aOR: 0.56, 95% CI: 0.16\u20131.92). However, neonates of people with TIR \u226470% were more likely to be admitted to the NICU (p\u2009=\u20090.035), to receive IV glucose (p\u2009=\u20090.005), to have RDS (p\u2009=\u20090.012), and had a longer hospital stay (p\u2009=\u20090.012) compared with people with TIR &gt;70%. Furthermore, people with TIR \u226470% were more likely to develop hypertensive disorders (p\u2009=\u20090.04) than those with TIR &gt;70%.<\/jats:p>\n                  <jats:p>Conclusion\u2003In this cohort, the target of TIR &gt;70% was reached in about one out of two people with diabetes using CGM, which correlated with a reduction in neonatal and maternal complications.<\/jats:p>\n                  <jats:p>Key Points<\/jats:p>","DOI":"10.1055\/a-1904-9279","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T18:56:05Z","timestamp":1658343365000},"page":"461-466","source":"Crossref","is-referenced-by-count":20,"title":["Time in Range and Pregnancy Outcomes in People with Diabetes Using Continuous Glucose Monitoring"],"prefix":"10.1055","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4715-566X","authenticated-orcid":false,"given":"Michal","family":"Fishel Bartal","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joycelyn A.","family":"Ashby Cornthwaite","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danna","family":"Ghafir","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Ward","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladys","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleaha","family":"Louis","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Cornthwaite","sequence":"additional","affiliation":[{"name":"Department of Earth, Environmental and Planetary Science, Rice University, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneet S. P.","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baha M.","family":"Sibai","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"issue":"02","key":"ref1","first-page":"1","article-title":"Births: final data for 2019","volume":"70","author":"J A Martin","year":"2021","journal-title":"Natl Vital Stat Rep"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1210\/js.2017-00376","article-title":"Trends in obstetric intervention and pregnancy outcomes of Canadian women with diabetes in pregnancy From 2004 to 2015","volume":"1","author":"A Metcalfe","year":"2017","journal-title":"J Endocr Soc"},{"issue":"09","key":"ref3","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1007\/s00125-017-4314-3","article-title":"Improved pregnancy outcomes in women with type 1 and type 2 diabetes but substantial clinic-to-clinic variations: a prospective nationwide study","volume":"60","author":"H R Murphy","year":"2017","journal-title":"Diabetologia"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"176.e1","DOI":"10.1016\/j.ajog.2019.08.028","article-title":"Specific birth defects in pregnancies of women with diabetes: National Birth Defects Prevention Study, 1997-2011","volume":"222","author":"S C Tinker","year":"2020","journal-title":"Am J Obstet Gynecol"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"123","DOI":"10.7326\/0003-4819-159-2-201307160-00661","article-title":"Benefits and harms of treating gestational diabetes mellitus: a systematic review and meta-analysis for the U.S. Preventive Services Task Force and the National Institutes of Health Office of Medical Applications of Research","volume":"159","author":"L Hartling","year":"2013","journal-title":"Ann Intern Med"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00125-013-3108-5","article-title":"Pre-existing diabetes, maternal glycated haemoglobin, and the risks of fetal and infant death: a population-based study","volume":"57","author":"P W Tennant","year":"2014","journal-title":"Diabetologia"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2337\/dc15-0433","article-title":"Gestational diabetes mellitus in early pregnancy: evidence for poor pregnancy outcomes despite treatment","volume":"39","author":"A N Sweeting","year":"2016","journal-title":"Diabetes Care"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1089\/dia.2018.0384","article-title":"State of type 1 diabetes management and outcomes from the T1D exchange in 2016-2018","volume":"21","author":"N C Foster","year":"2019","journal-title":"Diabetes Technol Ther"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1016\/S0140-6736(17)32400-5","article-title":"Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial","volume":"390","author":"D S Feig","year":"2017","journal-title":"Lancet"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"e14703","DOI":"10.1111\/dme.14703","article-title":"Efficacy of continuous glucose monitoring on maternal and neonatal outcomes in gestational 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Advani","year":"2020","journal-title":"Diabetologia"},{"issue":"02","key":"ref17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1089\/dia.2018.0310","article-title":"The relationship of hemoglobin A1C to time-in-range in patients with diabetes","volume":"21","author":"R A Vigersky","year":"2019","journal-title":"Diabetes Technol Ther"},{"issue":"08","key":"ref18","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.2337\/dci19-0028","article-title":"Clinical targets for continuous glucose monitoring data interpretation: recommendations from the International Consensus on Time in Range","volume":"42","author":"T Battelino","year":"2019","journal-title":"Diabetes Care"},{"issue":"07","key":"ref19","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s00125-019-4850-0","article-title":"Continuous glucose monitoring in pregnant women with type 1 diabetes: an observational cohort study of 186 pregnancies","volume":"62","author":"K Kristensen","year":"2019","journal-title":"Diabetologia"},{"issue":"07","key":"ref20","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00125-019-4904-3","article-title":"Continuous glucose monitoring targets in type 1 diabetes pregnancy: every 5% time in range matters","volume":"62","author":"H R Murphy","year":"2019","journal-title":"Diabetologia"},{"issue":"04","key":"ref21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1023\/A:1022381506823","article-title":"1994-1996 U.S. singleton birth weight percentiles for gestational age by race, Hispanic origin, and gender","volume":"3","author":"G R Alexander","year":"1999","journal-title":"Matern Child Health J"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1164\/ajrccm.149.3.7509706","article-title":"The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination","volume":"149","author":"G R Bernard","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"issue":"01","key":"ref23","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1097\/AOG.0000000000003606","article-title":"Macrosomia: ACOG Practice Bulletin, Number 216","volume":"135","year":"2020","journal-title":"Obstet Gynecol"},{"issue":"02","key":"ref24","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jpeds.2015.03.057","article-title":"Recommendations from the Pediatric Endocrine Society for Evaluation and Management of Persistent Hypoglycemia in Neonates, Infants, and Children","volume":"167","author":"P S Thornton","year":"2015","journal-title":"J Pediatr"},{"issue":"05","key":"ref25","first-page":"1122","article-title":"Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy","volume":"122","year":"2013","journal-title":"Obstet Gynecol"},{"issue":"04","key":"ref26","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1097\/AOG.0000000000002351","article-title":"Practice Bulletin No. 183: postpartum hemorrhage","volume":"130","author":"Committee on Practice Bulletins-Obstetrics","year":"2017","journal-title":"Obstet Gynecol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1089\/dia.2020.0667","article-title":"Benefits of real-time continuous glucose monitoring in pregnancy","volume":"23","author":"J M Yamamoto","year":"2021","journal-title":"Diabetes Technol Ther"},{"issue":"07","key":"ref29","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.2337\/dc12-2360","article-title":"The effect of real-time continuous glucose monitoring in pregnant women with diabetes: a randomized controlled trial","volume":"36","author":"A L Secher","year":"2013","journal-title":"Diabetes Care"},{"issue":"07","key":"ref30","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.2337\/dc15-0070","article-title":"Analysis of continuous glucose monitoring in pregnant women with diabetes: distinct temporal patterns of glucose associated with large-for-gestational-age infants","volume":"38","author":"G R Law","year":"2015","journal-title":"Diabetes Care"},{"issue":"05","key":"ref31","doi-asserted-by":"crossref","first-page":"810","DOI":"10.2337\/dc18-2212","article-title":"Suboptimal nocturnal glucose control is associated with large for gestational age in treated gestational diabetes mellitus","volume":"42","author":"G R Law","year":"2019","journal-title":"Diabetes Care"},{"issue":"08","key":"ref32","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1111\/dme.13988","article-title":"Maternal glycaemic control and risk of neonatal hypoglycaemia in Type 1 diabetes pregnancy: a secondary analysis of the CONCEPTT trial","volume":"36","author":"J M Yamamoto","year":"2019","journal-title":"Diabet Med"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1904-9279.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T15:17:14Z","timestamp":1700839034000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1904-9279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,20]]},"references-count":31,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2023,3,20]]},"published-print":{"date-parts":[[2023,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1904-9279","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,20]]},"published":{"date-parts":[[2022,7,20]]}}}