{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T02:47:01Z","timestamp":1748314021166,"version":"3.37.3"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>\n            Objective\u2003The aim of this study was to investigate fetal echocardiographic findings in predicting the need for surgical repair in fetuses with coarctation of the aorta (CoA) and to evaluate perinatal outcomes.<\/jats:p><jats:p>\n            Study Design\u2003In this retrospective study, fetuses diagnosed with CoA in a tertiary center between January 2015 and June 2021 were analyzed. Fetal echocardiographic measurements and quantitative findings, middle cerebral artery (MCA) and umbilical artery (UA) Doppler indices, and perinatal outcomes were recorded.<\/jats:p><jats:p>\n            Results\u2003A total of 57 fetuses with CoA were included in the study. In total, 51 (89.5%) pregnancies resulted in live births and 32 (62.8%) of the neonates underwent surgical repair. The left ventricle\/right ventricle width ratio and aortic isthmus z-score were significantly lower in fetuses who underwent surgical repair (p\u2009=\u20090.004 0.001, respectively). Retrograde flow in the aortic isthmus (odds ratio [OR]:7.43; 95% confidence interval [CI]: 1.98\u201327.76), left-to-right foramen ovale shunt (OR: 8.50; 95% CI: 1.68\u201342.98), and ventricular septal defect (OR: 9.63; 95% CI: 1.90\u201348.74) were associated with the need for surgical repair. A new scoring system integrating these echocardiographic findings had 89% specificity and 54% sensitivity in predicting surgical repair. Fetal growth restriction rates, preterm birth rates, mean MCA pulsatility index (PI), and mean UA PI were similar in fetuses with and without surgical repair.<\/jats:p><jats:p>\n            Conclusion\u2003A scoring system integrating echocardiographic findings in fetuses with CoA may improve the prediction of surgical repair need. There is no evidence of an increased risk of FGR, preterm birth, and brain sparing effect in fetuses with CoA who require surgical repair.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1904-9519","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T22:56:05Z","timestamp":1658357765000},"page":"1337-1347","source":"Crossref","is-referenced-by-count":2,"title":["Fetal Echocardiographic Findings to Predict Early Surgical Repair and Neonatal Outcomes in Fetuses with Isolated Coarctation of the Aorta"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3737-7712","authenticated-orcid":false,"given":"M\u00fcnip","family":"Akal\u0131n","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Marmara University Pendik Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5578-4437","authenticated-orcid":false,"given":"Oya","family":"Demirci","sequence":"additional","affiliation":[{"name":"Department of Perinatology, University of Health Sciences Zeynep Kamil Women's and Children's Disease Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4899-6025","authenticated-orcid":false,"given":"\u0130lker K.","family":"Y\u00fccel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, University of Health Sciences Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9650-2077","authenticated-orcid":false,"given":"Nurdan","family":"Erol","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, University of Health Sciences Zeynep Kamil Women's and Children's Disease Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.jpeds.2008.05.059","article-title":"Prevalence of congenital heart defects in metropolitan Atlanta, 1998-2005","volume":"153","author":"M D Reller","year":"2008","journal-title":"J Pediatr"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/S0735-1097(02)01886-7","article-title":"The incidence of congenital heart disease","volume":"39","author":"J I Hoffman","year":"2002","journal-title":"J Am Coll Cardiol"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"487","DOI":"10.5603\/CJ.2011.0003","article-title":"Coarctation of the aorta: from fetal life to 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