{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:53Z","timestamp":1740126833724,"version":"3.37.3"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"name":"Sickkids Foundation","award":["CDH Fund: R00DH00000"],"award-info":[{"award-number":["CDH Fund: R00DH00000"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003The etiology of congenital diaphragmatic hernia (CDH) remains unknown and only 10 to 30% of patients have a genetic cause. Seasonal variation is known to contribute to the development of some congenital anomalies. Our aim was to investigate whether CDH births have seasonal variation.<\/jats:p><jats:p>\n          Materials and Methods\u2003A literature review was conducted for CDH and seasonality. Moreover, data from the CDH International Patient Registry Database were collected for infants with due dates between 2008 and 2014. Due dates were used to determine seasonal distribution of births. Birth rates per month in the United States and Canada were extracted from publicly available databases. Data were analyzed using analysis of variance and contingency tables.<\/jats:p><jats:p>\n          Results\u2003First, the literature review revealed 11 articles, of which 3 were eligible for inclusion. These studies reported conflicting results on seasonality of CDH. Second, we extracted due dates from the CDH International Patient Registry Database (1,259 patients) and found that there were fewer due dates in winter months (12.1\u2009\u00b1\u20094 patients\/month) than in summer (16.7\u2009\u00b1\u20096 patients\/month; p\u2009=\u20090.011) and fall months (16.3\u2009\u00b1\u20095 patients\/month; p\u2009=\u20090.022). Although this trend was similar to that of all births in the United States and Canada, a lower incidence was observed in winter for CDH infants (20.2%) than for the general population (24.1%, p\u2009=\u20090.0012). CDH survival rate did not vary by season.<\/jats:p><jats:p>\n          Conclusion\u2003This study provides evidence for a seasonal variation of CDH births. No causative link was established between CDH development and seasonality. Population-based studies with a focus on exposome data are needed to explain seasonal variation in CDH.<\/jats:p>","DOI":"10.1055\/a-1905-4808","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T23:00:57Z","timestamp":1658358057000},"page":"011-016","source":"Crossref","is-referenced-by-count":4,"title":["Seasonal Variation of Congenital Diaphragmatic Hernia: A Review of the Literature and Database Report from the United States and Canada"],"prefix":"10.1055","volume":"33","author":[{"given":"Fabian","family":"Doktor","sequence":"additional","affiliation":[{"name":"Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Antounians","sequence":"additional","affiliation":[{"name":"Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Miller","sequence":"additional","affiliation":[{"name":"CDH Patient Registry, CDH International, Wake Forest, North Carolina, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Harb","sequence":"additional","affiliation":[{"name":"CDH Patient Registry, CDH International, Wake Forest, North Carolina, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Meats","sequence":"additional","affiliation":[{"name":"CDH Patient Registry, CDH International, Wake Forest, North Carolina, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Bercovitch","sequence":"additional","affiliation":[{"name":"Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5211-4005","authenticated-orcid":false,"given":"Dawn","family":"Ireland","sequence":"additional","affiliation":[{"name":"CDH Patient Registry, CDH International, Wake Forest, North Carolina, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto","family":"Zani","sequence":"additional","affiliation":[{"name":"Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"Department of Surgery, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1016\/j.jpedsurg.2020.06.022","article-title":"Prevalence and risk factors for congenital diaphragmatic hernia: a global view","volume":"55","author":"M Paoletti","year":"2020","journal-title":"J Pediatr Surg"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41572-022-00362-w","article-title":"Congenital diaphragmatic hernia","volume":"8","author":"A Zani","year":"2022","journal-title":"Nat Rev Dis Primers"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1016\/j.ajpath.2016.07.006","article-title":"Polygenic causes of congenital diaphragmatic hernia produce common lung pathologies","volume":"186","author":"P K Donahoe","year":"2016","journal-title":"Am J Pathol"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.siny.2014.09.003","article-title":"Genetic causes of congenital diaphragmatic hernia","volume":"19","author":"J Wynn","year":"2014","journal-title":"Semin Fetal Neonatal Med"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/(SICI)1096-8628(19980923)79:3<215::AID-AJMG13>3.0.CO;2-K","article-title":"Congenital diaphragmatic defects and associated syndromes, malformations, and chromosome anomalies: a retrospective study of 60 patients and literature review","volume":"79","author":"G M Enns","year":"1998","journal-title":"Am J Med Genet"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00439-017-1774-y","article-title":"Genome-wide enrichment of damaging de novo variants in patients with isolated and complex congenital diaphragmatic hernia","volume":"136","author":"M Longoni","year":"2017","journal-title":"Hum Genet"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s12887-021-02748-3","article-title":"Parental risk factors for congenital diaphragmatic hernia - a large German case-control study","volume":"21","author":"F Schulz","year":"2021","journal-title":"BMC Pediatr"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"153159","DOI":"10.1016\/j.tox.2022.153159","article-title":"Activation of retinoic acid-related orphan receptor \u03b3(t) by parabens and benzophenone UV-filters","volume":"471","author":"S G Inderbinen","year":"2022","journal-title":"Toxicology"},{"issue":"08","key":"ref9","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/bdra.20370","article-title":"Linking animal models to human congenital diaphragmatic hernia","volume":"79","author":"N Beurskens","year":"2007","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1055\/s-0039-1693993","article-title":"Congenital diaphragmatic hernia: state of the art in translating experimental research to the bedside","volume":"29","author":"L Antounians","year":"2019","journal-title":"Eur J Pediatr Surg"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"L317","DOI":"10.1152\/ajplung.00104.2018","article-title":"Inhibition of retinoic acid signaling induces aberrant pericyte coverage and differentiation resulting in vascular defects in congenital diaphragmatic hernia","volume":"317","author":"H M Kool","year":"2019","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"03","key":"ref12","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1165\/rcmb.2009-0076OC","article-title":"Understanding abnormal retinoid signaling as a causative mechanism in congenital diaphragmatic hernia","volume":"42","author":"R D Clugston","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"166198","DOI":"10.1016\/j.bbadis.2021.166198","article-title":"Pregnancy and viral infections: mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and Zika virus","volume":"1867","author":"C Auriti","year":"2021","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"09","key":"ref14","first-page":"e0112644","article-title":"Maternal viral infection and risk of fetal congenital heart diseases: a meta-analysis of observational studies","volume":"8","author":"Z Ye","year":"2019","journal-title":"J Am Heart Assoc"},{"issue":"03","key":"ref15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/bdra.20431","article-title":"Use of specified critical periods of different congenital abnormalities instead of the first trimester concept","volume":"82","author":"A E Czeizel","year":"2008","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"04","key":"ref16","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1136\/jech.43.4.330","article-title":"Seasonal prevalence of major congenital malformations in the Fylde of Lancashire 1957-1981","volume":"43","author":"J P Bound","year":"1989","journal-title":"J Epidemiol Community Health"},{"issue":"04","key":"ref17","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/humrep\/det455","article-title":"Influenza and congenital anomalies: a systematic review and meta-analysis","volume":"29","author":"J M Luteijn","year":"2014","journal-title":"Hum Reprod"},{"issue":"01","key":"ref18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11832-014-0558-3","article-title":"Seasonal variation in children with developmental dysplasia of the hip","volume":"8","author":"R T Loder","year":"2014","journal-title":"J Child Orthop"},{"issue":"01","key":"ref19","first-page":"1","article-title":"Births: final data for 2008","volume":"59","author":"J A Martin","year":"2010","journal-title":"Natl Vital Stat Rep"},{"issue":"01","key":"ref20","first-page":"1","article-title":"Births: final data for 2009","volume":"60","author":"J A Martin","year":"2011","journal-title":"Natl Vital Stat Rep"},{"issue":"01","key":"ref21","first-page":"1","article-title":"Births: final data for 2010","volume":"61","author":"J A Martin","year":"2012","journal-title":"Natl Vital Stat Rep"},{"issue":"01","key":"ref22","first-page":"1","article-title":"Births: final data for 2011","volume":"62","author":"J A Martin","year":"2013","journal-title":"Natl Vital Stat Rep"},{"issue":"09","key":"ref23","first-page":"1","article-title":"Births: final data for 2012","volume":"62","author":"J A Martin","year":"2013","journal-title":"Natl Vital Stat Rep"},{"issue":"01","key":"ref24","first-page":"1","article-title":"Births: final data for 2013","volume":"64","author":"J A Martin","year":"2015","journal-title":"Natl Vital Stat Rep"},{"issue":"12","key":"ref25","first-page":"1","article-title":"Births: final data for 2014","volume":"64","author":"B E Hamilton","year":"2015","journal-title":"Natl Vital Stat Rep"},{"issue":"02","key":"ref27","doi-asserted-by":"crossref","first-page":"28","DOI":"10.21699\/jns.v6i2.506","article-title":"Seasonality, epidemiology and outcome of congenital diaphragmatic hernia in south west of Iran","volume":"6","author":"M Dehdashtian","year":"2017","journal-title":"J Neonatal Surg"},{"issue":"06","key":"ref28","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/tera.1420460605","article-title":"A population-based study of congenital diaphragmatic hernia","volume":"46","author":"C P Torfs","year":"1992","journal-title":"Teratology"},{"issue":"01","key":"ref29","doi-asserted-by":"crossref","first-page":"e2021052151","DOI":"10.1542\/peds.2021-052151","article-title":"Environmental exposures and congenital heart disease","volume":"149","author":"R Boyd","year":"2022","journal-title":"Pediatrics"},{"issue":"05","key":"ref30","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jpedsurg.2020.01.016","article-title":"Sex differences in surgically correctable congenital anomalies: a systematic review","volume":"55","author":"A J Black","year":"2020","journal-title":"J Pediatr Surg"},{"issue":"06","key":"ref31","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.siny.2014.09.004","article-title":"The Congenital Diaphragmatic Hernia Study Group registry update","volume":"19","author":"M T Harting","year":"2014","journal-title":"Semin Fetal Neonatal Med"},{"issue":"01","key":"ref33","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrmicro.2017.118","article-title":"The evolution of seasonal influenza viruses","volume":"16","author":"V N Petrova","year":"2018","journal-title":"Nat Rev Microbiol"},{"issue":"06","key":"ref34","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1097\/EDE.0000000000000372","article-title":"The association of H1N1 pandemic influenza with congenital anomaly prevalence in Europe: an ecological time series study","volume":"26","author":"J M Luteijn","year":"2015","journal-title":"Epidemiology"},{"issue":"03","key":"ref35","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/pr.2013.98","article-title":"Fetal production of growth factors and inflammatory mediators predicts pulmonary hypertension in congenital diaphragmatic hernia","volume":"74","author":"S Fleck","year":"2013","journal-title":"Pediatr Res"},{"volume-title":"Proteomic profiling of hypoplastic lungs suggests an underlying inflammatory response in the pathogenesis of abnormal lung development in congenital diaphragmatic hernia","author":"R Wagner","key":"ref36","doi-asserted-by":"publisher","DOI":"10.1101\/2022.03.07.483298"}],"container-title":["European Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1905-4808.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T03:57:32Z","timestamp":1674014252000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1905-4808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,20]]},"references-count":34,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2023,1,17]]},"published-print":{"date-parts":[[2023,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1905-4808","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0939-7248","1439-359X"],"issn-type":[{"type":"print","value":"0939-7248"},{"type":"electronic","value":"1439-359X"}],"subject":[],"published-other":{"date-parts":[[2022,7,20]]},"published":{"date-parts":[[2022,7,20]]}}}