{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T04:10:17Z","timestamp":1728015017119},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Gegenstand und Ziel \u00dcber H\u00f6rverlust, der in zeitlichem Zusammenhang mit der topischen Anwendung von Otologika auftritt, wird dem Bundesamt f\u00fcr Verbraucherschutz und Lebensmittelsicherheit (BVL) regelm\u00e4\u00dfig in Form von Meldungen unerw\u00fcnschter Arzneimittelwirkungen (UAW) berichtet. Obwohl in den Fachinformationen der in Deutschland zugelassenen Otologika Taubheit oder Beeintr\u00e4chtigung des H\u00f6rverm\u00f6gens als m\u00f6gliche Nebenwirkungen aufgef\u00fchrt sind, gibt es \u00fcber die zugrundeliegenden Ursachen nur wenig Informationen.<\/jats:p><jats:p>Material und Methoden F\u00e4lle zu H\u00f6rverlust nach Anwendung von Otologika wurden in der nationalen UAW-Datenbank des BVL recherchiert und deskriptiv analysiert. Dabei wurden F\u00e4lle,<\/jats:p><jats:p>in denen Katzen betroffen waren, aufgrund der geringen Anzahl ausgeschlossen. M\u00f6gliche Risikofaktoren und Ursachen f\u00fcr H\u00f6rverlust wurden vor dem Hintergrund aktueller Literatur betrachtet.<\/jats:p><jats:p>Ergebnisse Obwohl in den Berichten Tiere aller Altersgruppen betroffen waren, bezog sich der \u00fcberwiegende Anteil der Meldungen auf Tiere, die \u00e4lter als 10\u2005Jahre waren. Nach Mischlingen waren am h\u00e4ufigsten Hunde der Rassen West Highland White Terrier, Dalmatiner, Zwergpudel und Franz\u00f6sische Bulldogge involviert. Die Analyse der vorliegenden Daten deutet nicht auf spezifische Pr\u00e4parate oder Wirkstoffe hin, welche mit geh\u00e4uftem Auftreten eines H\u00f6rverlusts in Verbindung stehen k\u00f6nnten.<\/jats:p><jats:p>Schlussfolgerung und klinische Relevanz Neben einer m\u00f6glichen Ototoxizit\u00e4t eines Pr\u00e4parates sollten auch andere Ursachen f\u00fcr den H\u00f6rverlust in Betracht gezogen werden, wie z.\u2005B. die zugrundeliegende Otitis selbst, Altersschwerh\u00f6rigkeit, eine bisher unentdeckte einseitige Taubheit oder Schallleitungstaubheit durch Obstruktion des Geh\u00f6rgangs. Neben dem Absetzen potenziell ototoxischer Stoffe kommt die Behandlung von Schallleitungstaubheit, z.\u2005B. durch die Entfernung von Medikamentenresten und Exsudat oder die Behandlung einer Otitis media, als Therapieoption infrage. Im Fall eines H\u00f6rverlusts nach der Anwendung von Otologika sollte eine m\u00f6glichst detaillierte Meldung dieses Ereignisses an das BVL erfolgen, um die Datenlage zu diesem Thema weiter zu verbessern.<\/jats:p>","DOI":"10.1055\/a-1907-4387","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T22:34:17Z","timestamp":1662503657000},"page":"269-278","source":"Crossref","is-referenced-by-count":0,"title":["H\u00f6rverlust nach Anwendung topischer Otitispr\u00e4parate bei Hunden"],"prefix":"10.1055","volume":"50","author":[{"given":"Ann","family":"Neubert","sequence":"additional","affiliation":[{"name":"Bundesamt f\u00fcr Verbraucherschutz und Lebensmittelsicherheit"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Tannert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwenda","family":"Pirk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,9,6]]},"reference":[{"issue":"01","key":"ref1","first-page":"97","article-title":"Canine otitis externa \u2013 Treatment and complications","volume":"60","author":"J Bajwa","year":"2019","journal-title":"Can Vet J"},{"issue":"03","key":"ref3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1055\/s-0033-1361557","article-title":"Otitis externa: topisch, systemisch oder chirurgisch?","volume":"17","author":"N Thom","year":"2014","journal-title":"kleintier konkret"},{"issue":"04","key":"ref5","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1136\/vr.142.4.78","article-title":"Evaluation of the canine tympanic membrane by positive contrast ear canalography","volume":"142","author":"N D Trower","year":"1998","journal-title":"Vet Rec"},{"issue":"01","key":"ref6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1136\/vr.124.1.5","article-title":"An evaluation of tympanometry, otoscopy and palpation for assessment of the canine tympanic membrane","volume":"124","author":"C J Little","year":"1989","journal-title":"Vet Rec"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"534","DOI":"10.2460\/javma.1998.212.04.534","article-title":"Microbial flora and antimicrobial susceptibility patterns of isolated pathogens from the horizontal ear canal and middle ear in dogs with otitis media","volume":"212","author":"L K Cole","year":"1998","journal-title":"J Am Vet Med Assoc"},{"issue":"09","key":"ref8","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/j.1748-5827.1997.tb03490.x","article-title":"Effects of otitis on hearing in dogs characterised by brainstem auditory evoked response testing","volume":"38","author":"C E Eger","year":"1997","journal-title":"J Small Anim Pract"},{"issue":"05","key":"ref9","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/vde.12057","article-title":"Use of a hearing loss grading system and an owner-based hearing questionnaire to assess hearing loss in pet dogs with chronic otitis externa or otitis media","volume":"24","author":"C L Mason","year":"2013","journal-title":"Vet Dermatol"},{"issue":"06","key":"ref10","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1016\/j.cvsm.2012.08.010","article-title":"Canine Deafness","volume":"42","author":"G M Strain","year":"2012","journal-title":"Veterinary Clinics of North America: Small Animal Practice"},{"issue":"06","key":"ref11","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1055\/s-0038-1623735","article-title":"Taubheit bei Hunden und Katzen: Ursachen, Diagnostik und Therapie","volume":"41","author":"J P Bach","year":"2013","journal-title":"Tierarztl Prax Ausg K Kleintiere Heimtiere"},{"issue":"01","key":"ref12","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0007-1935(96)80083-2","article-title":"Aetiology, prevalence and diagnosis of deafness in dogs and cats","volume":"152","author":"G M Strain","year":"1996","journal-title":"British Veterinary Journal"},{"issue":"03","key":"ref13","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1517\/14740338.5.3.383","article-title":"Understanding drug ototoxicity: molecular insights for prevention and clinical management","volume":"5","author":"J G Yorgason","year":"2006","journal-title":"Expert Opinion on Drug Safety"},{"issue":"04","key":"ref14","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1002\/cpt.603","article-title":"Drug-induced ototoxicity: Mechanisms, Pharmacogenetics, and protective strategies. 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