{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:20:24Z","timestamp":1781659224475,"version":"3.54.5"},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"11","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Clinical Research Project\n                        of Army Medical University","award":["2019XLC2009"],"award-info":[{"award-number":["2019XLC2009"]}]},{"name":"Clinical Research Project\n                        of Army Medical University","award":["2018XLC3049"],"award-info":[{"award-number":["2018XLC3049"]}]},{"DOI":"10.13039\/501100005230","name":"Chongqing Natural Science Foundation","doi-asserted-by":"crossref","award":["CSTC2020JCYJ-JQX0017"],"award-info":[{"award-number":["CSTC2020JCYJ-JQX0017"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose To investigate the clinical characteristics and associated factors\n                    of colonic polyps in patients with acromegaly.<\/jats:p><jats:p>\n          Methods Clinical characteristics and colonoscopy findings of 86 acromegaly\n                    patients who received treatment were retrospectively reviewed, and colonoscopy\n                    findings and the correlation with growth hormone (GH)-secreting pituitary\n                    adenoma (GHPA) volume and hormonal\/metabolic levels were analyzed.<\/jats:p><jats:p>\n          Results The prevalence of colonic polyps in acromegaly patients was\n                    40.7% and increased significantly with advanced age, especially in those\n                    \u226550 years. Multiple polyps (62.8%) and colonic polyps in the\n                    left colon (54.2%) were detected more frequently. Compared to acromegaly\n                    patients without polyps, those with polyps displayed higher insulin-like growth\n                    factor-1 \u00d7 upper limit of normal (IGF-1\u00d7ULN) levels\n                    (P=0.03). IGF-1 levels and GHPA volumes in patients with polyps\n                    showed increasing trends, although the differences were not significant. GH\n                    levels were higher in patients with polyps of diameter \u22645\u2009mm\n                    than those with polyps of diameter &gt;5\u2009mm\n                    (P=0.031). The univariate and multivariate logistic regression\n                    analysis revealed that GHPA volumes (OR: 1.09, 95% CI:\n                    1.01\u20131.20; P=0.039) and IGF-1\u00d7ULN Q2 levels (OR:\n                    6.51, 95% CI: 1.20\u201344.60; P=0.038) were\n                    independent factors for predicting the risk of colonic polyp occurrence in\n                    acromegaly patients. A nomogram was prepared to evaluate the risk of colonic\n                    polyps in acromegaly patients.<\/jats:p><jats:p>\n          Conclusion The acromegalic patients are a population with a high\n                    prevalence of colonic polyps. GHPA volumes and IGF-1\u00d7ULN levels may be\n                    predictors of colonic polyp occurrence.<\/jats:p>","DOI":"10.1055\/a-1913-7900","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T22:57:51Z","timestamp":1662677871000},"page":"714-722","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Characteristics and Associated Factors of Colonic Polyps in\n                    Acromegaly"],"prefix":"10.1055","volume":"130","author":[{"given":"Guiliang","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Translational Research Key Laboratory for\n                    Diabetes, The Second A\ufb03liated Hospital (Xinqiao Hospital), Army Medical\n                    University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jinling Hospital, Medical School of\n                    Nanjing University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second A\ufb03liated Hospital\n                    (Xinqiao Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianying","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second A\ufb03liated Hospital\n                    (Xinqiao Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pian","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Translational Research Key Laboratory for\n                    Diabetes, The Second A\ufb03liated Hospital (Xinqiao Hospital), Army Medical\n                    University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Translational Research Key Laboratory for\n                    Diabetes, The Second A\ufb03liated Hospital (Xinqiao Hospital), Army Medical\n                    University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Translational Research Key Laboratory for\n                    Diabetes, The Second A\ufb03liated Hospital (Xinqiao Hospital), Army Medical\n                    University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second A\ufb03liated Hospital (Xinqiao\n                    Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Translational Research Key Laboratory for\n                    Diabetes, The Second A\ufb03liated Hospital (Xinqiao Hospital), Army Medical\n                    University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Translational Research Key Laboratory for\n                    Diabetes, The Second A\ufb03liated Hospital (Xinqiao Hospital), Army Medical\n                    University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Translational Research Key Laboratory for\n                    Diabetes, The Second A\ufb03liated Hospital (Xinqiao Hospital), Army Medical\n                    University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Diabetes, Endocrinology and\n                    Metabolism, Baylor College of Medicine, Houston, Texas, USA; Department of\n                    Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas,\n                    USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rufei","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Translational Research Key Laboratory for\n                    Diabetes, The Second A\ufb03liated Hospital (Xinqiao Hospital), Army Medical\n                    University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongting","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Translational Research Key Laboratory for\n                    Diabetes, The Second A\ufb03liated Hospital (Xinqiao Hospital), Army Medical\n                    University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Translational Research Key Laboratory for\n                    Diabetes, The Second A\ufb03liated Hospital (Xinqiao Hospital), Army Medical\n                    University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ecl.2007.10.002","article-title":"Acromegaly","volume":"37","author":"A Ben-Shlomo","year":"2008","journal-title":"Endocrinol Metab Clin North 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Parolin","year":"2018","journal-title":"Pituitary"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1530\/EJE-19-0813","article-title":"Clinicopathological features of colorectal polyps and risk of colorectal cancer\n                    in acromegaly","volume":"182","author":"Y Ochiai","year":"2020","journal-title":"Eur J Endocrinol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"594","DOI":"10.4158\/ep161724.Or","article-title":"The prevalence of colonic polyps in patients with acromegaly: A case-control,\n                    nested in a cohort colonoscopic study","volume":"23","author":"B Gonzalez","year":"2017","journal-title":"Endocr Pract"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/s11102-020-01090-8","article-title":"Increased risk of preneoplastic colonic lesions and colorectal carcinoma in\n                    acromegaly: Multicenter case-control study","volume":"24","author":"M F 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Metab"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1007\/s11102-014-0586-5","article-title":"The role of colonoscopic screening in acromegaly revisited: Review of current\n                    literature and practice guidelines","volume":"18","author":"K Lois","year":"2015","journal-title":"Pituitary"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"378","DOI":"10.7326\/0003-4819-156-5-201203060-00010","article-title":"Screening for colorectal cancer: A guidance statement from the American College\n                    of Physicians","volume":"156","author":"A Qaseem","year":"2012","journal-title":"Ann Intern Med"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"643","DOI":"10.7326\/m19-0642","article-title":"Screening for colorectal cancer in asymptomatic average-risk adults: A guidance\n                    statement from the American College of Physicians","volume":"171","author":"A Qaseem","year":"2019","journal-title":"Ann Intern Med"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1136\/gut.2009.179804","article-title":"Guidelines for colorectal cancer screening and surveillance in moderate and high\n                    risk groups (update from 2002","volume":"59","author":"S R Cairns","year":"2010","journal-title":"Gut"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1530\/eje-09-1080","article-title":"Repeated colonoscopic screening of patients with acromegaly: 15-year experience\n                    identifies those at risk of new colonic neoplasia and allows for effective\n                    screening guidelines","volume":"163","author":"D Dworakowska","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"ref36","first-page":"29","article-title":"Canadian consensus guidelines for the diagnosis and management of\n                    acromegaly","volume":"29","author":"S Ezzat","year":"2006","journal-title":"Clin Invest Med"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4158\/ep.17.s4.1","article-title":"American Association of Clinical Endocrinologists medical guidelines for\n                    clinical practice for the diagnosis and treatment of acromegaly--2011\n                    update","volume":"17","author":"L Katznelson","year":"2011","journal-title":"Endocr Pract"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1007\/s11102-012-0420-x","article-title":"A consensus on the diagnosis and treatment of acromegaly complications","volume":"16","author":"S Melmed","year":"2013","journal-title":"Pituitary"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"250","DOI":"10.3322\/caac.21457","article-title":"Colorectal cancer screening for average-risk adults: 2018 guideline update from\n                    the American Cancer Society","volume":"68","author":"AM D Wolf","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"V13","DOI":"10.1136\/gut.51.suppl_5.v13","article-title":"Screening guidelines for colorectal cancer and polyps in patients with\n                    acromegaly","volume":"51","author":"P J Jenkins","year":"2002","journal-title":"Gut"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1507\/endocrj.EJ17-0322","article-title":"Colonoscopy examination requires a longer time in patients with acromegaly than\n                    in other individuals","volume":"65","author":"M Iwamuro","year":"2018","journal-title":"Endocr J"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1111\/j.1572-0241.2005.40808.x","article-title":"Risk of colorectal neoplasm in patients with acromegaly and its relationship\n                    with serum growth hormone levels","volume":"100","author":"Y Matano","year":"2005","journal-title":"Am J 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