{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:07:27Z","timestamp":1783987647827,"version":"3.55.0"},"reference-count":46,"publisher":"Georg Thieme Verlag KG","issue":"11","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"German Research Foundation DFG","award":["SFB834 B12, project number 75732319"],"award-info":[{"award-number":["SFB834 B12, project number 75732319"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>\n            Background\u2003The noncoding antisense transcript for \u03b2-secretase-1 (BACE1-AS) is a long noncoding RNA with a pivotal role in the regulation of amyloid-\u03b2 (A\u03b2). We aimed to explore the clinical value of BACE1-AS expression in atherosclerotic cardiovascular disease (ASCVD).<\/jats:p><jats:p>\n            Methods\u2003Expression of BACE1-AS and its target, \u03b2-secretase 1 (BACE1) mRNA, was measured in peripheral blood mononuclear cells derived from 434 individuals (259 without established ASCVD [non-CVD], 90 with stable coronary artery disease [CAD], and 85 with acute coronary syndrome). Intima-media thickness and atheromatous plaques evaluated by ultrasonography, as well as arterial wave reflections and pulse wave velocity, were measured as markers of subclinical ASCVD. Patients were followed for a median of 52 months for major adverse cardiovascular events (MACE).<\/jats:p><jats:p>\n            Results\u2003In the cross-sectional arm, BACE1-AS expression correlated with BACE1 expression (r\u2009=\u20090.396, p\u2009&lt;\u20090.001) and marginally with A\u03b21\u201340 levels in plasma (r\u2009=\u20090.141, p\u2009=\u20090.008). Higher BACE1-AS was associated with higher estimated CVD risk assessed by HeartScore for non-CVD subjects and by European Society of Cardiology clinical criteria for the total population (p\u2009&lt;\u20090.05 for both). BACE1-AS was associated with higher prevalence of CAD (odds ratio [OR]\u2009=\u20091.85, 95% confidence interval [CI]: 1.37\u20132.5), multivessel CAD (OR\u2009=\u20091.36, 95% CI: 1.06\u20131.75), and with higher number of diseased vascular beds (OR\u2009=\u20091.31, 95% CI: 1.07\u20131.61, for multiple diseased vascular beds) after multivariable adjustment for traditional cardiovascular risk factors. In the prospective arm, BACE1-AS was an independent predictor of MACE in high cardiovascular risk patients (adjusted hazard ratio\u2009=\u20091.86 per ascending tertile, 95% CI: 1.011\u20133.43, p\u2009=\u20090.046).<\/jats:p><jats:p>\n            Conclusion\u2003BACE1-AS is associated with the incidence and severity of ASCVD.<\/jats:p>","DOI":"10.1055\/a-1914-2094","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T06:53:26Z","timestamp":1659423206000},"page":"1932-1942","source":"Crossref","is-referenced-by-count":20,"title":["Beta-Secretase-1 Antisense RNA Is Associated with Vascular Ageing and Atherosclerotic Cardiovascular Disease"],"prefix":"10.1055","volume":"122","author":[{"given":"Dimitrios","family":"Bampatsias","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Mavroeidis","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Tual-Chalot","sequence":"additional","affiliation":[{"name":"Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos I.","family":"Vlachogiannis","sequence":"additional","affiliation":[{"name":"Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bonini","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, European Center for Angioscience (ECAS), Heidelberg University, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Sachse","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, European Center for Angioscience (ECAS), Heidelberg University, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Mavraganis","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia","family":"Mareti","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysoula","family":"Kritsioti","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ageliki","family":"Laina","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Delialis","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Ciliberti","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, European Center for Angioscience (ECAS), Heidelberg University, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kateryna","family":"Sopova","sequence":"additional","affiliation":[{"name":"Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Gatsiou","sequence":"additional","affiliation":[{"name":"Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Martelli","sequence":"additional","affiliation":[{"name":"Molecular Cardiology Laboratory, IRCCS Policlinico San Donato, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Georgiopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Stellos","sequence":"additional","affiliation":[{"name":"Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom"},{"name":"Department of Cardiovascular Research, European Center for Angioscience (ECAS), Heidelberg University, Mannheim, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), partner site Heidelberg\/Mannheim, Mannheim, Germany"},{"name":"Department of Cardiology, University Hospital Mannheim, Heidelberg University, Manheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimon","family":"Stamatelopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece"},{"name":"Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/CIRCRESAHA.117.308903","article-title":"Reducing the global burden of cardiovascular disease, part 1: the epidemiology and risk factors","volume":"121","author":"P Joseph","year":"2017","journal-title":"Circ 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