{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T05:23:15Z","timestamp":1666156995617},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund\u2002Nach Empfehlungen der letzten PH-Weltkonferenz wird die Differenzierung von isoliert postkapill\u00e4rer (Ipc) und kombiniert post- und pr\u00e4kapill\u00e4rer (Cpc) PH allein nach pulmonal-vaskul\u00e4rem Widerstand (PVR) empfohlen. Ziel dieser Arbeit war es, Patienten mit IpcPH und CpcPH nach den aktualisierten Empfehlungen basierend auf der letzten Weltkonferenz f\u00fcr pulmonale Hypertonie (PH) h\u00e4modynamisch und im Rahmen einer explorativen Datenanalyse funktionell zu charakterisieren.<\/jats:p><jats:p>\n          Methoden\u2002Evaluiert wurden Patienten, die sich von 2008 bis 2015 in der PH-Ambulanz der Missioklinik W\u00fcrzburg mit Verdacht auf PH zur leitlinienkonformen Diagnostik vorstellten. Analysiert wurden alle Patienten mit einem pulmonal-arteriellen Mitteldruck (mPAP) von \u2265\u200a25\u200ammHg und einem pulmonalkapill\u00e4ren Verschlussdruck (PCWP) &gt;\u200a15\u200ammHg. Es erfolgte der Vergleich anthropometrischer, h\u00e4modynamischer und funktioneller Daten aus 6-Minuten-Gehtest (6 MWT), Spiroergometrie und Echokardiografie bei IpcPH und CpcPH.<\/jats:p><jats:p>\n          Ergebnisse\u2002Von 726 Patienten zeigten 58 eine postkapill\u00e4re PH: IpcPH: n\u200a=\u200a20; CpcPH: n\u200a=\u200a38.\u200aPatienten mit IpcPH besa\u00dfen einen signifikant niedrigeren mPAP und PVR als Patienten mit CpcPH. Der Herzindex war in der CpcPH-Gruppe niedriger als in der IpcPH-Gruppe. Die funktionelle Kapazit\u00e4t beider Gruppen war nicht verschieden. Patienten mit CpcPH hatten einen gr\u00f6\u00dferen rechts-linksatrialen Fl\u00e4chen(RA\/LA)-Quotienten.<\/jats:p><jats:p>\n          Diskussion und Schlussfolgerung\u2002Trotz h\u00f6herem mPAP und PVR von Patienten mit CpcPH findet sich keine schlechtere funktionelle Kapazit\u00e4t als bei IpcPH. Bei Patienten mit Linksherzerkrankungen und PH kann ein erh\u00f6hter RA\/LA-Index ein m\u00f6glicher Hinweis f\u00fcr eine CpcPH sein und Anlass zur invasiven Diagnostik geben.<\/jats:p>","DOI":"10.1055\/a-1916-1431","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T22:38:37Z","timestamp":1666132717000},"page":"689-696","source":"Crossref","is-referenced-by-count":0,"title":["Funktionelle Charakterisierung von Patienten mit isoliert postkapill\u00e4rer oder kombiniert post- und pr\u00e4kapill\u00e4rer pulmonaler Hypertonie"],"prefix":"10.1055","volume":"76","author":[{"given":"Matthias","family":"Held","sequence":"additional","affiliation":[{"name":"Medizinische Klinik mit Schwerpunkt Pneumologie und Beatmungsmedizin, Standort Missioklinik, Klinikum W\u00fcrzburg Mitte gGmbH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Weiner","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Diagnostische und Interventionelle Neuroradiologie, Universit\u00e4tsklinikum W\u00fcrzburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Walthelm","sequence":"additional","affiliation":[{"name":"Medizinische Klinik mit Schwerpunkt Pneumologie und Beatmungsmedizin, Standort Missioklinik, Klinikum W\u00fcrzburg Mitte gGmbH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Joa","sequence":"additional","affiliation":[{"name":"Medizinische Klinik mit Schwerpunkt Pneumologie und Beatmungsmedizin, Standort Missioklinik, Klinikum W\u00fcrzburg Mitte gGmbH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Thorax-, Herz- und Thorakale Gef\u00e4\u00dfchirurgie, Universit\u00e4tsklinikum W\u00fcrzburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fclmisal","family":"G\u00fcder","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I, Schwerpunkt Kardiologie, Universit\u00e4tsklinikum W\u00fcrzburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Pfeuffer-Jovic","sequence":"additional","affiliation":[{"name":"Medizinische Klinik mit Schwerpunkt Pneumologie und Beatmungsmedizin, Standort Missioklinik, Klinikum W\u00fcrzburg Mitte gGmbH"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1801897","DOI":"10.1183\/13993003.01897-2018","article-title":"Pulmonary hypertension due to left heart disease","volume":"53 (01)","author":"J L Vachi\u00e9ry","year":"2019","journal-title":"The European respiratory journal"},{"issue":"03","key":"ref2","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1378\/chest.12-1653","article-title":"Diastolic Pulmonary Vascular Pressure Gradient. 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