{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T01:38:15Z","timestamp":1720575495173},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"S 02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gesundheitswesen"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Ziel der Studie Ziel unserer Arbeit war es, die geschlechtsspezifischen\n                    Unterschiede in der Diagnostik und Therapie von Patienten mit peripherer\n                    arterieller Verschlusskrankheit (pAVK) im Stadium der Claudicatio intermittens\n                    (IC) auf Grundlage von Sekund\u00e4rdaten zu analysieren. Weiterhin sollte\n                    der Einfluss des biologischen Geschlechts auf kurz- und langfristige\n                    Therapieerfolge bestimmt werden.<\/jats:p><jats:p>\n          Methodik Das GenderVasc Projekt erfolgt in Kooperation mit dem\n                    Wissenschaftlichen Institut der AOK (WIdO) und als Datengrundlage dienten\n                    Sekund\u00e4rdaten aller AOK-Versicherten, die aufgrund einer pAVK im Stadium\n                    der IC station\u00e4r behandelt wurden. Neben den intersektoralen\n                    Querschnittsanalysen wurden auch longitudinale Analysen mit einem Follow-up von\n                    bis zu 5 Jahren durchgef\u00fchrt.<\/jats:p><jats:p>\n          Ergebnisse Die durchgef\u00fchrten Analysen der Sekund\u00e4rdaten\n                    von 42.197 pAVK Patienten im Stadium der IC zeigten, dass M\u00e4nner\n                    h\u00e4ufiger im Krankenhaus behandelt wurden und Frauen zum Zeitpunkt der\n                    Behandlung \u00e4lter waren (Frauen: 72,6 vs. M\u00e4nner: 66,4 Jahre).\n                    Weiterhin war die Rate an durchgef\u00fchrten vaskul\u00e4ren Prozeduren\n                    (diagnostische Angiographie und Revaskularisierung) bei Frauen mit IC geringer.\n                    Auch die Verschreibung von leitliniengerechten Medikamenten (Statine und\n                    Blutverd\u00fcnner) war bei weiblichen Patienten niedriger im Vergleich zu\n                    M\u00e4nnern. Eine multivariate Cox Regression zeigte nach Adjustierung auf\n                    Alter, kardiovaskul\u00e4re Risikoprofil und den durchgef\u00fchrten\n                    vaskul\u00e4ren Prozeduren, dass das weibliche Geschlecht protektiv\n                    bez\u00fcglich des Gesamt\u00fcberlebens und des Voranschreitens der pAVK\n                    (Progress zu einer chronischen Extremit\u00e4tenisch\u00e4mie oder\n                    isch\u00e4mische Amputation) ist.<\/jats:p><jats:p>\n          Schlussfolgerung In Deutschland sind weibliche pAVK Patienten im Stadium\n                    der IC \u00e4lter und bekommen weniger h\u00e4ufig die nach den\n                    Leitlinien-empfohlene Therapie, w\u00e4hrend Frauen ein besseres Outcome\n                    aufweisen. Inwieweit das erh\u00f6hte Alter oder Vorhandensein anderer\n                    Komorbidit\u00e4ten die Entscheidung zu einer vaskul\u00e4ren Prozedur\n                    beeinflusst, kann bei einer Sekund\u00e4rdatenanalyse nur vermutet werden.\n                    Weiterhin ist die Verschreibung von Medikamenten bei multimorbiden Patienten\n                    eine Herausforderung und auch die Compliance der Patienten ist nicht Teil\n                    unserer Analysen gewesen. Nichtsdestotrotz sind gezielte Analysen, wie im Rahmen\n                    des GenderVasc Projektes, dringend erforderlich, um zu Grunde liegende\n                    Versorgungsdefizite aufzudecken und anzugehen.<\/jats:p>","DOI":"10.1055\/a-1916-9717","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T22:47:29Z","timestamp":1664405249000},"page":"S127-S134","source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Geschlechtsspezifische Unterschiede in der Versorgung und dem Outcome\n                    von pAVK Patienten \u2013 Eine Sekund\u00e4rdatenanalyse-"],"prefix":"10.1055","volume":"85","author":[{"given":"Lena","family":"Makowski","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie I: Koronare Herzkrankheit,\n                    Herzinsuffizienz und Angiologie, Universit\u00e4tsklinikum M\u00fcnster,\n                    M\u00fcnster, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jannik","family":"Feld","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biometrie und Klinische Forschung,\n                    Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster,\n                    M\u00fcnster, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Engelbertz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie I: Koronare Herzkrankheit,\n                    Herzinsuffizienz und Angiologie, Universit\u00e4tsklinikum M\u00fcnster,\n                    M\u00fcnster, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette","family":"K\u00f6ppe","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biometrie und Klinische Forschung,\n                    Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster,\n                    M\u00fcnster, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonie","family":"K\u00fchnemund","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie I: Koronare Herzkrankheit,\n                    Herzinsuffizienz und Angiologie, Universit\u00e4tsklinikum M\u00fcnster,\n                    M\u00fcnster, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Fischer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie III: Angeborene Herzfehler (EMAH) und\n                    Klappenerkrankungen, Universit\u00e4tsklinikum M\u00fcnster,\n                    M\u00fcnster, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan A","family":"Lange","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie I: Koronare Herzkrankheit,\n                    Herzinsuffizienz und Angiologie, Universit\u00e4tsklinikum M\u00fcnster,\n                    M\u00fcnster, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrik","family":"Dr\u00f6ge","sequence":"additional","affiliation":[{"name":"Qualit\u00e4ts- und Versorgungsforschung, Wissenschaftliches\n                    Institut der AOK (WIdO), Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Ruhnke","sequence":"additional","affiliation":[{"name":"Qualit\u00e4ts- und Versorgungsforschung, Wissenschaftliches\n                    Institut der AOK (WIdO), Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"G\u00fcnster","sequence":"additional","affiliation":[{"name":"Qualit\u00e4ts- und Versorgungsforschung, Wissenschaftliches\n                    Institut der AOK (WIdO), Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasser","family":"Malyar","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie I: Koronare Herzkrankheit,\n                    Herzinsuffizienz und Angiologie, Universit\u00e4tsklinikum M\u00fcnster,\n                    M\u00fcnster, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Ger\u00df","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biometrie und Klinische Forschung,\n                    Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster,\n                    M\u00fcnster, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Freisinger","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie I: Koronare Herzkrankheit,\n                    Herzinsuffizienz und Angiologie, Universit\u00e4tsklinikum M\u00fcnster,\n                    M\u00fcnster, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Reinecke","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie I: Koronare 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