{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:18Z","timestamp":1787004858124,"version":"build-2736575974"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"11","license":[{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background and study aims\u2002Endoscopic techniques are rapidly emerging for resection of subepithelial tumors (SETs). Submucosal tunneling for endoscopic resection (STER), endoscopic full-thickness resection (EFTR) and laparoscopic endoscopic cooperative surgery (LECS) are current alternatives to open surgery. In this study, we aimed to compare the three endoscopic techniques.<\/jats:p>\n                  <jats:p>Patients and methods\u2002Consecutive patients who underwent resection of a submucosal esophageal or gastric lesion at several tertiary care centers were included in a dedicated registry over 3 years. Demographics, size and location of resected lesion, histology of specimen, length of procedure, adverse events (AEs), duration of hospital stay, and follow-up data were collected.<\/jats:p>\n                  <jats:p>Results\u2002Ninety-six patients were included (47.7\u200a% male, mean age 62): STER n\u200a=\u200a34, EFTR n\u200a=\u200a34, LECS n\u200a=\u200a280.\u200aThe lesions included leiomyoma, gastrointestinal stromal tumors (GISTs) and other. The mean lesion size was 28\u200amm (STD 16, range 20\u201372\u200amm). The majority of lesions in the EFTR and laparoscopic-assisted resection group were GISTs. There was no significant difference in clear resection margins, post-procedure complication rates, recurrence rate and total follow-up duration between the groups. However, the LECS group had a procedure time at least 30 minutes longer than STER or EFTR (P\u200a&lt;\u200a0.01). Total hospital stay for the laparoscopic-assisted resection group was also longer when compared to STER (1.5) and EFTR (1.8) (P\u200a&lt;\u200a0.01).<\/jats:p>\n                  <jats:p>Conclusions\u2002STER, EFTR, and laparoscopic-assisted resection are efficacious approaches for resection of SETs with similar R0 resection rates, complication rates, and AE rates. Laparoscopic assisted resection appears more time-consuming and is associated with a longer hospital stay.<\/jats:p>","DOI":"10.1055\/a-1922-7890","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T18:49:26Z","timestamp":1660243766000},"page":"E1491-E1496","source":"Crossref","is-referenced-by-count":16,"title":["Subepithelial tumors: How does endoscopic full-thickness resection &amp; submucosal tunneling with endoscopic resection compare with laparoscopic endoscopic cooperative surgery?"],"prefix":"10.1055","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0836-6114","authenticated-orcid":false,"given":"Michel","family":"Kahaleh","sequence":"additional","affiliation":[{"name":"Gastroenterology, Robert Wood Johnson University, New Brunswick, New Jersey, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky","family":"Bhagat","sequence":"additional","affiliation":[{"name":"Gastroenterology, Robert Wood Johnson University, New Brunswick, New Jersey, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Dellatore","sequence":"additional","affiliation":[{"name":"Gastroenterology, Robert Wood Johnson University, New Brunswick, New Jersey, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Tyberg","sequence":"additional","affiliation":[{"name":"Gastroenterology, Robert Wood Johnson University, New Brunswick, New Jersey, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avik","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Gastroenterology, Robert Wood Johnson University, New Brunswick, New Jersey, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haroon M.","family":"Shahid","sequence":"additional","affiliation":[{"name":"Gastroenterology, Robert Wood Johnson University, New Brunswick, New Jersey, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Andalib","sequence":"additional","affiliation":[{"name":"Gastroenterology, Robert Wood Johnson University, New Brunswick, New Jersey, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Resheed","family":"Alkhiari","sequence":"additional","affiliation":[{"name":"Gastroenterology, Robert Wood Johnson University, New Brunswick, New Jersey, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Gaidhane","sequence":"additional","affiliation":[{"name":"Gastroenterology, Robert Wood Johnson University, New Brunswick, New Jersey, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Kedia","sequence":"additional","affiliation":[{"name":"Gastroenterology, Methodist Hospital, Dallas, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Nieto","sequence":"additional","affiliation":[{"name":"Borland-Groover Clinic, Jacksonville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil A.","family":"Kumta","sequence":"additional","affiliation":[{"name":"Gastroenterology, Mount Sinai Hospital, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah E.","family":"Dixon","sequence":"additional","affiliation":[{"name":"Gastroenterology, Mount Sinai Hospital, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habeeb","family":"Salameh","sequence":"additional","affiliation":[{"name":"Gastroenterology, Mount Sinai Hospital, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Mavrogenis","sequence":"additional","affiliation":[{"name":"Gastroenterology, Mytilene Hospital, Mytilene, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanos","family":"Bassioukas","sequence":"additional","affiliation":[{"name":"Gastroenterology, Latpikin, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2736-6921","authenticated-orcid":false,"given":"Seiichiro","family":"Abe","sequence":"additional","affiliation":[{"name":"Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor N.","family":"Arentes","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio H.","family":"Morita","sequence":"additional","affiliation":[{"name":"Gastroenterology, University of Sao Paulo Medical School, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Sakai","sequence":"additional","affiliation":[{"name":"Gastroenterology, University of Sao Paulo Medical School, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-3722","authenticated-orcid":false,"given":"Eduardo G.","family":"de Moura","sequence":"additional","affiliation":[{"name":"Gastroenterology, University of Sao Paulo Medical School, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"ref1","first-page":"5085","article-title":"Current status of submucosal tunneling endoscopic resection for gastrointestinal submucosal tumors originating from the muscularis propria layer 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endoscopic resection for upper gastrointestinal submucosal tumors","volume":"48","author":"T Chen","year":"2016","journal-title":"Endoscopy"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.dld.2012.08.010","article-title":"Submucosal tunnelling endoscopic resection for the treatment of esophageal submucosal tumours originating from the muscularis propria layer: an analysis of 15 cases","volume":"45","author":"L P Ye","year":"2013","journal-title":"Dig Liver Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"620","DOI":"10.5009\/gnl15424","article-title":"Endoscopic submucosal tunnel dissection for upper gastrointestinal submucosal tumors originating from the muscularis propria layer: a single-center study","volume":"11","author":"X Tang","year":"2017","journal-title":"Gut Liver"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1007\/s00464-015-4567-1","article-title":"Comparison between submucosal tunneling 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