{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:02:49Z","timestamp":1790416969969,"version":"4.1.0"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"name":"CAMS Innovation Fund for Medical Sciences","award":["2020-I2M-C&T-A-017"],"award-info":[{"award-number":["2020-I2M-C&T-A-017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003Primary frontal sinus malignancies (FSMs) are the rarest sinonasal cancers. This study aimed to determine clinicopathologic characteristics of primary FSMs and provide long-term survival outcomes.<\/jats:p><jats:p>\n          Design\u2003This study is a retrospective review.<\/jats:p><jats:p>\n          Setting\u2003The study was conducted at a tertiary medical center.<\/jats:p><jats:p>\n          Participants\u2003Patients who participated in this study were diagnosed with primary FSMs.<\/jats:p><jats:p>\n          Main Outcome Measures\u2003Median survival time is the primary outcome measure of this study.<\/jats:p><jats:p>\n          Results\u2003In this series, the median age was 48 years (30\u201353 years) and all patients were male. There were five cases with squamous cell carcinoma and one with osteosarcoma. All cases presented with locally advanced disease without regional lymphatic metastasis, including five cases of stage III and one case of stage II. The two most common pathways of tumor invasion were as follows: local tumor broke posteriorly through bone wall and invaded dura mater, followed by frontal lobe; local tumor infiltrated downward through the floor of frontal sinus into ethmoid sinus, thereafter invaded laterally orbit and orbital contents. All patients received surgery followed by postoperative radiotherapy at the total doses of 50 to 75.95 Gy. Among them, only one patient underwent R0 resection, the rest of patients underwent R1\/R2 resection. With a median survival time of 56 months (32\u201376 months), two patients receiving R1\/R2 resection developed treatment failure and died within 5 years, including one case with local recurrence and one with local recurrence, thereafter distant metastasis.<\/jats:p><jats:p>\n          Conclusion\u2003The majority of FSMs presented with peripherally invasive progression lesions which led to a high ratio of R1\/R2 resection. Surgery combined with postoperative radiotherapy might result in satisfactory efficacy.<\/jats:p>","DOI":"10.1055\/a-1924-9319","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T01:05:41Z","timestamp":1660698341000},"page":"609-615","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Characteristics and Long-Term Outcomes following Surgery Combined with Adjuvant Radiotherapy for Patients with Frontal Sinus Malignancies"],"prefix":"10.1055","volume":"84","author":[{"given":"Ze-Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Lin","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"},{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Hebei Cancer Hospital, Chinese Academy of Medical Sciences, Langfang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run-Ye","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-Hu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Song","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Dong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Zhen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 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J.Terris D","year":"2005"},{"issue":"16","key":"ref20","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1002\/cncr.30686","article-title":"A comprehensive comparative analysis of treatment modalities for sinonasal malignancies","volume":"123","author":"T P Robin","year":"2017","journal-title":"Cancer"},{"issue":"03","key":"ref21","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3109\/02841860903428176","article-title":"Carcinoma of the nasal cavity and paranasal sinuses in Denmark 1995-2004","volume":"49","author":"C Thorup","year":"2010","journal-title":"Acta Oncol"},{"issue":"08","key":"ref22","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nrclinonc.2014.97","article-title":"Sinonasal carcinoma: clinical, pathological, genetic and therapeutic advances","volume":"11","author":"J L Llorente","year":"2014","journal-title":"Nat Rev Clin Oncol"},{"issue":"03","key":"ref23","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/hed.24639","article-title":"ACR appropriateness criteria nasal cavity and paranasal sinus cancers","volume":"39","author":"F Siddiqui","year":"2017","journal-title":"Head Neck"},{"issue":"02","key":"ref24","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ejso.2006.10.033","article-title":"Single modality and multimodality treatment of nasal and paranasal sinuses cancer: a single institution experience of 229 patients","volume":"33","author":"O Guntinas-Lichius","year":"2007","journal-title":"Eur J Surg Oncol"},{"issue":"03","key":"ref25","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.soc.2015.03.009","article-title":"Cancers of the nose, sinus, and skull base","volume":"24","author":"V Banuchi","year":"2015","journal-title":"Surg Oncol Clin N Am"},{"issue":"02","key":"ref26","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.otc.2016.12.006","article-title":"Transfacial and craniofacial approaches for resection of sinonasal and ventral skull base malignancies","volume":"50","author":"E L Perkins","year":"2017","journal-title":"Otolaryngol Clin North Am"},{"issue":"01","key":"ref27","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.oraloncology.2012.07.009","article-title":"Lymph node metastasis in sinonasal squamous cell carcinoma treated with IMRT\/3D-CRT","volume":"49","author":"X Guan","year":"2013","journal-title":"Oral Oncol"},{"issue":"01","key":"ref28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ijrobp.2011.05.044","article-title":"Intensity-modulated radiotherapy for tumors of the nasal cavity and paranasal sinuses: clinical outcomes and patterns of failure","volume":"83","author":"E A Wiegner","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Journal of Neurological Surgery Part B: Skull Base"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1924-9319.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T22:47:55Z","timestamp":1697582875000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1924-9319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":28,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2023,10,17]]},"published-print":{"date-parts":[[2023,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1924-9319","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6331","2193-634X"],"issn-type":[{"value":"2193-6331","type":"print"},{"value":"2193-634X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,8,16]]},"published":{"date-parts":[[2022,8,16]]}}}