{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:03:52Z","timestamp":1791893032418,"version":"4.3.4"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003A recent randomized controlled trial suggested that early gestational diabetes mellitus (GDM) screening in patients with obesity (body mass index [BMI] \u226530\u2009kg\/m2) does not improve perinatal outcomes. The American College of Obstetrics and Gynecology currently recommends early screening for gestational diabetes in patients who are overweight with one or more additional risk factors. We evaluated the effect of screening based on the number of additional risk factors for development of gestational diabetes.<\/jats:p><jats:p>\n            Study Design\u2003This was a secondary analysis of a multicenter randomized controlled trial of obese patients with singleton nonanomalous fetuses comparing early (14\u201320 weeks' gestation) with routine (24\u201328 weeks' gestation) GDM screening. Exclusion criteria were pregestational diabetes, major medical illnesses, bariatric surgery, chronic steroid use, and prior cesarean. Early versus routine GDM screening groups were compared and stratified by the number of additional risk factors for GDM (0, 1, 2, and \u22653). The primary outcome was an adverse perinatal composite outcome composed of: macrosomia, primary cesarean delivery, hypertensive disorders of pregnancy, shoulder dystocia, neonatal hyperbilirubinemia, and neonatal hypoglycemia. Analyses examined effects of early versus routine screening by the number of additional risk factors and their possible interaction on the incidences of the primary outcome and GDM.<\/jats:p><jats:p>\n            Results\u2003Of 913 patients, 5% had 0, 52% had 1, 33% had 2, and 10% had \u22653 additional risk factors. Baseline characteristics, including the number and type of risk factors, were similar between early and routine screening groups. Breslow\u2013Day test for interaction between early versus routine screening and the number of additional risk factors was not significant for either the primary outcome (p\u2009=\u20090.37) or the diagnosis of GDM (p\u2009=\u20090.28). The incidence of GDM and the adverse perinatal composite outcome increased as the number of risk factors increased (p\u2009&lt;\u20090.001).<\/jats:p><jats:p>\n            Conclusion\u2003In patients with BMI \u226530\u2009kg\/m2 and additional risk factors, early GDM screening does not prevent adverse outcomes.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1925-1134","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T01:03:30Z","timestamp":1660698210000},"page":"e641-e647","source":"Crossref","is-referenced-by-count":6,"special_numbering":"S","title":["Early Gestational Diabetes Screening Based on ACOG Guidelines"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6011-8161","authenticated-orcid":false,"given":"Macie L.","family":"Champion","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, The University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria C.","family":"Jauk","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, The University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Biggio","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Ochsner Health System, New Orleans, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff M.","family":"Sychowski","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, The University of Alabama at Birmingham, Birmingham, Alabama"},{"name":"Department of Biostatistics, The University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan T.","family":"Tita","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, The University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0132-2194","authenticated-orcid":false,"given":"Lorie M.","family":"Harper","sequence":"additional","affiliation":[{"name":"Department of Women's Health, The University of Texas at Austin Dell Medical School, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2337\/diacare.27.2007.S88","article-title":"Gestational diabetes mellitus","volume":"27","author":"American Diabetes Association","year":"2004","journal-title":"Diabetes Care"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1001\/jama.2021.7217","article-title":"Trends in gestational diabetes at first live birth by race and ethnicity in the US, 2011-2019","volume":"326","author":"N S Shah","year":"2021","journal-title":"JAMA"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00592-014-0668-x","article-title":"Low-educated women have an increased risk of gestational diabetes mellitus: the Generation R Study","volume":"52","author":"S H Bouthoorn","year":"2015","journal-title":"Acta Diabetol"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s12013-014-0248-2","article-title":"Risk factors and management of gestational diabetes","volume":"71","author":"P Chen","year":"2015","journal-title":"Cell Biochem Biophys"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1097\/AOG.0000000000002501","article-title":"ACOG Practice Bulletin No. 190: gestational diabetes mellitus","volume":"131","year":"2018","journal-title":"Obstet Gynecol"},{"issue":"01","key":"ref6","first-page":"1","article-title":"ACOG Practice Bulletin No. 202: gestational hypertension and preeclampsia","volume":"133","year":"2019","journal-title":"Obstet Gynecol"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"616.e1","DOI":"10.1016\/j.ajog.2010.01.082","article-title":"Maternal and paternal race\/ethnicity are both associated with gestational diabetes","volume":"202","author":"A B Caughey","year":"2010","journal-title":"Am J Obstet Gynecol"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"414","DOI":"10.7326\/M13-2905","article-title":"Screening for gestational diabetes mellitus: U.S. Preventive Services Task Force recommendation statement","volume":"160","author":"V A Moyer","year":"2014","journal-title":"Ann Intern Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.2337\/dc10-S062","article-title":"Diagnosis and classification of diabetes mellitus","volume":"33","author":"American Diabetes Association","year":"2010","journal-title":"Diabetes Care"},{"issue":"05","key":"ref10","doi-asserted-by":"crossref","first-page":"495.e1","DOI":"10.1016\/j.ajog.2019.12.021","article-title":"Early gestational diabetes screening in obese women: a randomized controlled trial","volume":"222","author":"L M Harper","year":"2020","journal-title":"Am J Obstet Gynecol"},{"issue":"01","key":"ref11","first-page":"87","article-title":"ACOG practice bulletin: shoulder dystocia. Number 40, November 2002. (Replaces practice pattern number 7, October 1997)","volume":"80","author":"R J Sokol","year":"2003","journal-title":"Int J Gynaecol Obstet"},{"issue":"01","key":"ref12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1542\/peds.114.1.297","article-title":"Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation","volume":"114","author":"American Academy of Pediatrics Subcommittee on Hyperbilirubinemia","year":"2004","journal-title":"Pediatrics"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1055\/s-0036-1581055","article-title":"First trimester hemoglobin A1c prediction of gestational diabetes","volume":"33","author":"S S Osmundson","year":"2016","journal-title":"Am J Perinatol"},{"issue":"08","key":"ref14","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1055\/s-0036-1571317","article-title":"Impact of early screening for gestational diabetes on perinatal outcomes in high-risk women","volume":"33","author":"W Y Hong","year":"2016","journal-title":"Am J Perinatol"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1925-1134.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:14:34Z","timestamp":1730812474000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1925-1134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":14,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1925-1134","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,8,16]]},"published":{"date-parts":[[2022,8,16]]}}}