{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T06:59:55Z","timestamp":1771916395055,"version":"3.50.1"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003Our objective was to evaluate the safety and efficacy of casirivimab\/imdevimab therapy in pregnant women with severe coronavirus disease 2019 (COVID-19) requiring oxygen therapy.<\/jats:p><jats:p>\n          Study Design\u2003This was a prospective case series study aimed to evaluate the safety and efficacy of casirivimab\/imdevimab therapy in unvaccinated pregnant women with severe COVID-19. Inclusion criteria were severe acute respiratory syndrome coronavirus 2 infection documented with polymerase chain reaction, pregnancy, severe COVID-19 requiring oxygen therapy, duration of symptoms of 10 days or less, and able to provide informed consent. Vaccinated women and those with mild-to-moderate disease were excluded from the study. Included patients received casirivimab and imdevimab as a single intravenous dose of 4,000\/4,000\u2009mg. Women were also treated with low molecular weight heparin, steroids, and antibiotics, if necessary. The primary outcome was maternal death. Secondary outcomes were the rate of adverse events during infusion or within 72\u2009hours and the rate of abortion.<\/jats:p><jats:p>\n          Results\u2003Thirteen hospitalized unvaccinated pregnant women with severe COVID-19 requiring oxygen and treated with casirivimab\/imdevimab were included in the study. We observed no maternal death, and no patients required intubation or admission to the intensive care unit. No abortion or fetal loss was recorded. Nine pregnancies were still ongoing, and there were three cesarean deliveries and one vaginal delivery. Two were preterm deliveries (at 31 and 34 weeks), and two were term deliveries.<\/jats:p><jats:p>\n          Conclusion\u2003Casirivimab\/imdevimab therapy may be considered as a therapy in unvaccinated pregnant women with severe COVID-19.<\/jats:p>","DOI":"10.1055\/a-1925-2017","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T01:03:30Z","timestamp":1660698210000},"page":"e612-e616","source":"Crossref","is-referenced-by-count":1,"special_numbering":"S","title":["Casirivimab and Imdevimab for Pregnant Women Hospitalized for Severe Coronavirus Disease 2019"],"prefix":"10.1055","volume":"41","author":[{"given":"Buonomo A.","family":"Riccardo","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saccone","family":"Gabriele","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esposito","family":"Nunzia","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di Filippo","family":"Isabella","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinchera","family":"Biagio","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Foggia","family":"Maria","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zappulo","family":"Emanuela","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giaccone","family":"Agnese","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schiano M.","family":"Nicola","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viceconte","family":"Giulio","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scotto","family":"Riccardo","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bifulco","family":"Giuseppe","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gentile","family":"Ivan","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/uog.23107","article-title":"Maternal and perinatal outcomes of pregnant women with SARS-COV-2 infection","volume":"57","author":"WAPM. (The World\u2009Association\u2009of\u2009Perinatal\u2009Medicine) working group on COVID-19","year":"2021","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ejogrb.2020.04.006","article-title":"The novel coronavirus (2019-nCoV) in pregnancy: what we need to know","volume":"249","author":"G Saccone","year":"2020","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"100107","DOI":"10.1016\/j.ajogmf.2020.100107","article-title":"Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis","volume":"2","author":"D Di Mascio","year":"2020","journal-title":"Am J Obstet Gynecol MFM"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"100110","DOI":"10.1016\/j.ajogmf.2020.100110","article-title":"Labor and delivery guidance for COVID-19","volume":"2","author":"R C Boelig","year":"2020","journal-title":"Am J Obstet Gynecol MFM"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"100106","DOI":"10.1016\/j.ajogmf.2020.100106","article-title":"MFM guidance for COVID-19","volume":"2","author":"R C Boelig","year":"2020","journal-title":"Am J Obstet Gynecol MFM"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"B19","DOI":"10.1016\/j.ajog.2021.08.039","article-title":"Society for maternal-fetal medicine special statement: COVID-19 research in pregnancy: progress and potential","volume":"225","author":"R C Boelig","year":"2021","journal-title":"Am J Obstet Gynecol"},{"issue":"21","key":"ref7","doi-asserted-by":"crossref","first-page":"8277","DOI":"10.3390\/ijerph17218277","article-title":"Guidelines for pregnancy management during the COVID-19 pandemic: a public health conundrum","volume":"17","author":"C Benski","year":"2020","journal-title":"Int J Environ Res Public 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Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1925-2017.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:50:37Z","timestamp":1730814637000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1925-2017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":15,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1925-2017","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,8,16]]},"published":{"date-parts":[[2022,8,16]]}}}