{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:44:43Z","timestamp":1788965083687,"version":"build-2803163510"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"12","funder":[{"name":"Ludwig Boltzmann Cluster for Cardiovascular Research"},{"DOI":"10.13039\/501100011012","name":"Gesellschaft f\u00fcr Thrombose- und H\u00e4mostaseforschung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011012","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Association for the Promotion of Research on Arteriosclerosis, Thrombosis, and Vascular Biology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>\n            Background\u2003Alongside its original diagnostic intention, the International Society on Thrombosis and Haemostasis' (ISTH) disseminated intravascular coagulation (DIC) score predicts mortality in various patient groups.<\/jats:p><jats:p>\n            Objectives\u2003We investigated whether coagulopathy quantified by the DIC score can predict 30-day mortality in patients with liver disease and low fibrinogen levels.<\/jats:p><jats:p>\n            Methods\u2003We retrospectively analyzed all patients admitted to the Vienna General Hospital between 2003 and 2014 with a fibrinogen level of &lt;150\u2009mg\/dL, a history of liver disease, and \u22652 pathological DIC parameters. We used a Cox regression and receiver operating characteristic analysis to assess the predictive value of the ISTH DIC score in its original (DIC-2001) and revised form (DIC-2018).<\/jats:p><jats:p>\n            Results\u2003A total of 1,333 patients were screened, and 388 of these patients (38% female, median age: 58 years, interquartile range: 48\u201366 years) were analyzed. The DIC-2001 (hazard ratio [HR]: 2.08, 95% confidence interval [CI]: 1.78\u20132.59, p\u2009&lt;\u20090.001) and DIC-2018 (HR: 1.73, 95% CI: 1.51\u20132.05, p\u2009&lt;\u20090.001) predicted 30-day mortality. The results remained robust in several sensitivity analyses.<\/jats:p><jats:p>\n            Conclusion\u2003The ISTH DIC-2001 and DIC-2018 scores predicted 30-day mortality in patients with liver disease and low fibrinogen levels. The DIC score deserves further investigation in this population as it likely reflects different dimensions of the underlying disease.<\/jats:p>","DOI":"10.1055\/a-1925-2300","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T01:00:22Z","timestamp":1660698022000},"page":"1980-1987","source":"Crossref","is-referenced-by-count":10,"title":["Disseminated Intravascular Coagulation Score Predicts Mortality in Patients with Liver Disease and Low Fibrinogen Level"],"prefix":"10.1055","volume":"122","author":[{"given":"Juergen","family":"Grafeneder","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"},{"name":"Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Buchtele","sequence":"additional","affiliation":[{"name":"Department of Medicine I - Intensive Care Unit 13i2, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Egger","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schwameis","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cihan","family":"Ay","sequence":"additional","affiliation":[{"name":"Division of Haematology, Department of Medicine I, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Jilma","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schoergenhofer","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1538-7836.2007.02313.x","article-title":"The scoring system of the Scientific and Standardisation Committee on Disseminated Intravascular Coagulation of the International Society on Thrombosis and Haemostasis: a 5-year overview","volume":"5","author":"C H Toh","year":"2007","journal-title":"J Thromb Haemost"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1111\/jth.14134","article-title":"A re-evaluation of the D-dimer cut-off value for making a diagnosis according to the ISTH overt-DIC 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