{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:32:54Z","timestamp":1769506374595,"version":"3.49.0"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"S 01","funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"crossref","award":["21243039"],"award-info":[{"award-number":["21243039"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003Heart rate variability (HRV) indicates cardiac autonomic nerve activity and is influenced by brain damage during the neonatal period. We aimed to determine whether a correlation exists between the HRV of extremely preterm neonates and neurodevelopmental test scores.<\/jats:p><jats:p>\n            Study Design\u2003Electrocardiogram data of neonates were assessed and HRV patterns in extremely preterm neonates with severe intraventricular hemorrhage (IVH; n\u2009=\u20096) and those with no\/mild IVH (n\u2009=\u200928) were compared. We analyzed the relationship between HRV and neurodevelopmental outcomes at 18 months (n\u2009=\u200921) and 3 years (n\u2009=\u200923) in extremely preterm neonates.<\/jats:p><jats:p>\n            Results\u2003HRV was significantly associated with IVH severity in extremely preterm neonates (p\u2009&lt;\u20090.05). Neonates with severe IVH exhibited increased HR and decreased mean R-to-R interval (NN) compared with neonates with no\/mild IVH. HRV parameters significantly decreased in the severe IVH group, but not in the no\/mild IVH group, suggesting that both sympathetic and parasympathetic activities decreased in neonates with severe IVH. Additionally, decreased HR and increased NN were significantly related to impaired neurodevelopmental outcomes in the no\/mild IVH group at corrected ages of 18 months and 3 years, respectively (all p\u2009&lt;\u20090.05).<\/jats:p><jats:p>\n            Conclusion\u2003HRV was significantly associated with IVH severity and neurodevelopmental outcome in extremely preterm neonates. HRV can distinguish extremely preterm neonates who subsequently had severe IVH from those who had no\/low-grade IVH. HRV may identify extremely preterm neonates needing adjuvant neuroprotective interventions. These findings warrant further investigation in a larger population of extremely preterm neonates.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1926-0335","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T23:26:37Z","timestamp":1660778797000},"page":"e577-e583","source":"Crossref","is-referenced-by-count":4,"special_numbering":"S","title":["Autonomic Nervous System in Preterm Very Low Birth Weight Neonates with Intraventricular Hemorrhage"],"prefix":"10.1055","volume":"41","author":[{"given":"Ai","family":"Shiono","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatrics, National Hospital Organization Mie Chuo Medical Center, Mie, Japan"},{"name":"Department of Pediatrics, Mie University Graduate School of Medicine, Mie, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoki","family":"Bonno","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatrics, National Hospital Organization Mie Chuo Medical Center, Mie, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemi","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Mie University Graduate School of Medicine, Mie, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatrics, National Hospital Organization Mie Chuo Medical Center, Mie, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatrics, National Hospital Organization Mie Chuo Medical Center, Mie, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Mie University Graduate School of Medicine, Mie, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"issue":"07","key":"ref1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/ped.13317","article-title":"Perfusion monitoring and intraventricular hemorrhage in preterm infants","volume":"59","author":"A Ishiguro","year":"2017","journal-title":"Pediatr Int (Roma)"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1542\/peds.2015-0944","article-title":"Periventricular\/intraventricular hemorrhage and neurodevelopmental outcomes: a meta-analysis","volume":"136","author":"A Mukerji","year":"2015","journal-title":"Pediatrics"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"4896","DOI":"10.1007\/s12035-017-0693-1","article-title":"Cognitive impairment and brain and peripheral alterations in a murine model of intraventricular hemorrhage in the preterm newborn","volume":"55","author":"A Segado-Arenas","year":"2018","journal-title":"Mol Neurobiol"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1542\/peds.2013-0372","article-title":"Intraventricular hemorrhage and neurodevelopmental outcomes in extreme preterm infants","volume":"133","author":"S Bolisetty","year":"2014","journal-title":"Pediatrics"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1007\/s00381-012-1897-3","article-title":"Impact of low-grade intraventricular hemorrhage on long-term neurodevelopmental outcome in preterm infants","volume":"28","author":"K Klebermass-Schrehof","year":"2012","journal-title":"Childs Nerv Syst"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jpeds.2006.04.002","article-title":"Grades I-II intraventricular hemorrhage in extremely low birth weight infants: effects on neurodevelopment","volume":"149","author":"K Patra","year":"2006","journal-title":"J Pediatr"},{"issue":"07","key":"ref7","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1651-2227.2012.02677.x","article-title":"Early single-channel aEEG\/EEG predicts outcome in very preterm infants","volume":"101","author":"S Wikstr\u00f6m","year":"2012","journal-title":"Acta Paediatr"},{"issue":"08","key":"ref8","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1111\/j.1651-2227.2010.01809.x","article-title":"An international survey of EEG use in the neonatal intensive care unit","volume":"99","author":"G Boylan","year":"2010","journal-title":"Acta Paediatr"},{"issue":"05","key":"ref9","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/pr.2015.28","article-title":"Heart rate variability in hypoxic ischemic encephalopathy: correlation with EEG grade and 2-y neurodevelopmental outcome","volume":"77","author":"R M Goulding","year":"2015","journal-title":"Pediatr Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.autneu.2007.04.008","article-title":"Autonomic nervous system activity in premature and full-term infants from theoretical term to 7 years","volume":"136","author":"I De Rogalski Landrot","year":"2007","journal-title":"Auton Neurosci"},{"issue":"06","key":"ref11","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10286-004-0216-9","article-title":"Birth prematurity determines prolonged autonomic nervous system immaturity","volume":"14","author":"H Patural","year":"2004","journal-title":"Clin Auton Res"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1088\/0967-3334\/30\/2\/008","article-title":"Fetal heart rate variability reveals differential dynamics in the intrauterine development of the sympathetic and parasympathetic branches of the autonomic nervous system","volume":"30","author":"U Schneider","year":"2009","journal-title":"Physiol Meas"},{"issue":"03","key":"ref13","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/oxfordjournals.eurheartj.a014868","article-title":"Heart rate variability. Standards of measurement, physiological interpretation, and clinical use","volume":"17","author":"Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology","year":"1996","journal-title":"Eur Heart J"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1542\/peds.65.1.50","article-title":"Factors affecting heart rate variability in preterm infants","volume":"65","author":"L A Cabal","year":"1980","journal-title":"Pediatrics"},{"issue":"07","key":"ref16","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s00381-017-3436-8","article-title":"Autonomic nervous system in newborns: a review based on heart rate variability","volume":"33","author":"S Cardoso","year":"2017","journal-title":"Childs Nerv Syst"},{"issue":"02","key":"ref17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0378-3782(92)90111-S","article-title":"Heart rate variability in normal sleeping full-term and preterm neonates","volume":"28","author":"J Clairambault","year":"1992","journal-title":"Early Hum Dev"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1097\/00003246-200012000-00030","article-title":"Heart rate variability after acute traumatic brain injury in children","volume":"28","author":"A K Biswas","year":"2000","journal-title":"Crit Care Med"},{"issue":"11","key":"ref19","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1109\/TBME.2009.2026908","article-title":"Newborn seizure detection based on heart rate variability","volume":"56","author":"M B Malarvili","year":"2009","journal-title":"IEEE Trans Biomed Eng"},{"issue":"01","key":"ref20","first-page":"67","article-title":"Time-frequency analysis of heart rate variability for neonatal seizure detection","volume":"29","author":"M B Malarvili","year":"2006","journal-title":"Australas Phys Eng Sci Med"},{"issue":"12","key":"ref21","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1016\/j.clinph.2018.10.001","article-title":"Heart rate variability in neonatal patients with seizures","volume":"129","author":"R Statello","year":"2018","journal-title":"Clin Neurophysiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12871-015-0047-3","article-title":"Appropriate sevoflurane concentration to stabilize autonomic activity during intubation with rocuronium in infants: a randomized controlled trial","volume":"15","author":"H Hanamoto","year":"2015","journal-title":"BMC Anesthesiol"},{"issue":"06","key":"ref23","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/ped.14149","article-title":"Validity of stress assessment using heart-rate variability in newborns","volume":"62","author":"K Hashiguchi","year":"2020","journal-title":"Pediatr Int (Roma)"},{"issue":"04","key":"ref24","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","article-title":"Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm","volume":"92","author":"L A Papile","year":"1978","journal-title":"J Pediatr"},{"issue":"05","key":"ref25","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.braindev.2015.11.001","article-title":"Comparison of the Kyoto Scale of Psychological Development 2001 with the parent-rated Kinder Infant Development Scale (KIDS)","volume":"38","author":"S Aoki","year":"2016","journal-title":"Brain Dev"},{"issue":"02","key":"ref26","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1440-1819.2009.01931.x","article-title":"Utility of the Kyoto Scale of Psychological Development in cognitive assessment of children with pervasive developmental disorders","volume":"63","author":"T Koyama","year":"2009","journal-title":"Psychiatry Clin Neurosci"},{"issue":"01","key":"ref27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.earlhumdev.2010.10.004","article-title":"Neurodevelopmental outcomes of very low birth weight and extremely low birth weight infants at 18 months of corrected age associated with prenatal risk factors","volume":"87","author":"S Tamaru","year":"2011","journal-title":"Early Hum Dev"},{"issue":"05","key":"ref28","doi-asserted-by":"crossref","first-page":"E1448","DOI":"10.3390\/jcm9051448","article-title":"Developmental evaluation of infants who have received Tadalafil in utero for fetal growth restriction","volume":"9","author":"S Maki","year":"2020","journal-title":"J Clin Med"},{"issue":"01","key":"ref29","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00431-007-0435-x","article-title":"Outcome of extremely low birth weight survivors at school age: the influence of perinatal parameters on neurodevelopment","volume":"167","author":"A P Neubauer","year":"2008","journal-title":"Eur J Pediatr"},{"issue":"01","key":"ref30","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s12887-019-1603-7","article-title":"Severity of hypoxic ischemic encephalopathy and heart rate variability in neonates: a systematic review","volume":"19","author":"M Andersen","year":"2019","journal-title":"BMC Pediatr"},{"issue":"01","key":"ref31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000493002","article-title":"Prognostic accuracy of heart rate variability analysis in neonatal encephalopathy: a systematic review","volume":"115","author":"V Oliveira","year":"2019","journal-title":"Neonatology"},{"issue":"S 02","key":"ref32","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.33549\/physiolres.933676","article-title":"Heart rate variability in newborns","volume":"66","author":"K Javorka","year":"2017","journal-title":"Physiol Res"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1926-0335.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:13:50Z","timestamp":1730812430000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1926-0335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,17]]},"references-count":31,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1926-0335","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,8,17]]},"published":{"date-parts":[[2022,8,17]]}}}