{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T05:45:32Z","timestamp":1743745532173},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>\n            Purpose\u2002Several studies report an association of sarcopenia with survival in oncologic patients. The aim of this study is to assess the influence of sarcopenia on overall survival (OS) in patients with colorectal liver metastases undergoing interstitial brachytherapy (iBT)<\/jats:p><jats:p>\n            Methods\u2002We identified 144 patients with colorectal liver metastases from our database from 2014\u20132017. Computed tomography (CT) chest scans at the L3 level were retrospectively analyzed. Psoas muscle area (PMA), psoas muscle index (PMI), and skeletal muscle gauge (SMG) were measured on the CT scan before treatment. Parameters were associated with overall survival.<\/jats:p><jats:p>\n            Results\u2002116 patients were included. Median overall survival was 27 months. Median PMA was 13.79\u200acm2, median PMI 4.51\u200acm2\/m2. Neither PMA (HR 1.036, 95\u200a% CI 0.996\u20131.078, p\u200a=\u200a0.080), PMI (HR 1.068, 95\u200a% CI 0.922\u20131.238, p\u200a=\u200a0.382), nor SMG (HR 1.00, 95\u200a% CI 0.998\u20131.003, p\u200a=\u200a0.955) were significantly associated with overall survival.<\/jats:p><jats:p>\n            Conclusion\u2002Sarcopenic patients undergoing iBT for colorectal liver metastases did not show decreased overall survival. If confirmed by comparative studies, sarcopenia may serve as a biomarker for treatment decision in patients with CRLM.<\/jats:p><jats:p>\n            Key points:\u2002Sarcopenia is not a risk factor for survival in patients with CLRM undergoing iBT.<\/jats:p><jats:p>\n            Citation Format\n          <\/jats:p>","DOI":"10.1055\/a-1936-2937","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T22:36:56Z","timestamp":1666737416000},"page":"217-223","source":"Crossref","is-referenced-by-count":2,"title":["Sarcopenia does not limit overall survival in patients with colorectal liver metastases undergoing interstitial brachytherapy"],"prefix":"10.1055","volume":"195","author":[{"given":"Maximilian","family":"Thormann","sequence":"additional","affiliation":[{"name":"University Clinic for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Heitmann","sequence":"additional","affiliation":[{"name":"University Clinic for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Wrobel","sequence":"additional","affiliation":[{"name":"University Clinic for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Barajas Ordonez","sequence":"additional","affiliation":[{"name":"University Clinic for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Pech","sequence":"additional","affiliation":[{"name":"University Clinic for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey","family":"Surov","sequence":"additional","affiliation":[{"name":"University Clinic for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Damm","sequence":"additional","affiliation":[{"name":"University Clinic for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jazan","family":"Omari","sequence":"additional","affiliation":[{"name":"University Clinic for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ejca.2019.12.014","article-title":"Impact of colorectal cancer screening on cancer-specific mortality in Europe: A systematic review","volume":"127","author":"A Gini","year":"2020","journal-title":"Eur J Cancer"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.1002\/cncr.32163","article-title":"Targeted therapy for colorectal cancer metastases: A review of current methods of molecularly targeted therapy and the use of tumor biomarkers in the treatment of metastatic colorectal cancer","volume":"125","author":"S Piawah","year":"2019","journal-title":"Cancer"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1093\/annonc\/mdw235","article-title":"ESMO consensus guidelines for the management of patients with metastatic colorectal cancer","volume":"27","author":"E Van Cutsem","year":"2016","journal-title":"Ann Oncol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.ejca.2013.12.008","article-title":"Local recurrence rates after radiofrequency ablation or resection of colorectal liver metastases. Analysis of the European Organisation for Research and Treatment of Cancer #40004 and #40983","volume":"50","author":"E Tanis","year":"2014","journal-title":"Eur J Cancer"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1148\/radiol.2015142489","article-title":"Percutaneous Radiofrequency Ablation of Colorectal Cancer Liver Metastases: Factors Affecting Outcomes \u2013 A 10-year Experience at a Single Center","volume":"278","author":"W Shady","year":"2016","journal-title":"Radiology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1109\/TBME.2014.2367543","article-title":"A review of basic to clinical studies of irreversible electroporation therapy","volume":"62","author":"C Jiang","year":"2015","journal-title":"IEEE Trans Biomed Eng"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1200\/JCO.2015.66.1181","article-title":"SIRFLOX: Randomized Phase III Trial Comparing First-Line mFOLFOX6 (Plus or Minus Bevacizumab) Versus mFOLFOX6 (Plus or Minus Bevacizumab) Plus Selective Internal Radiation Therapy in Patients With Metastatic Colorectal Cancer","volume":"34","author":"G A Van Hazel","year":"2016","journal-title":"J Clin Oncol"},{"key":"ref8","first-page":"606","article-title":"Unresectable Colorectal Liver Metastases: Percutaneous Ablation Using CT-Guided High-Dose-Rate Brachytherapy (CT-HDBRT). R\u00f6Fo \u2013 Fortschritte auf dem Gebiet der R\u00f6ntgenstrahlen und der Bildgeb","volume":"186","author":"F Collettini","year":"2014","journal-title":"Verfahren"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"A J Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3350\/cmh.2017.0077","article-title":"Clinical usefulness of psoas muscle thickness for the diagnosis of sarcopenia in patients with liver cirrhosis","volume":"24","author":"D H Gu","year":"2018","journal-title":"Clin Mol Hepatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s12931-019-1191-y","article-title":"Computed tomography-derived area and density of pectoralis muscle associated disease severity and longitudinal changes in chronic obstructive pulmonary disease: a case control study","volume":"20","author":"S H Bak","year":"2019","journal-title":"Respir Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1158\/1078-0432.CCR-16-2266","article-title":"Body Composition as a Predictor of Toxicity in Patients Receiving Anthracycline and Taxane-Based Chemotherapy for Early-Stage Breast Cancer","volume":"23","author":"S S Shachar","year":"2017","journal-title":"Clin Cancer Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s00384-018-3128-1","article-title":"Can sarcopenia be a predictor of prognosis for patients with non-metastatic colorectal cancer? A systematic review and meta-analysis","volume":"33","author":"G Sun","year":"2018","journal-title":"Int J Colorectal Dis"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doy115","article-title":"Preoperative sarcopenia is a predictor of poor prognosis of esophageal cancer after esophagectomy: a comprehensive systematic review and meta-analysis","volume":"32","author":"H Y Deng","year":"2019","journal-title":"Dis Esophagus"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ijsu.2018.09.014","article-title":"Sarcopenia and sarcopenic obesity are significantly associated with poorer overall survival in patients with pancreatic cancer: Systematic review and meta-analysis","volume":"59","author":"I Mintziras","year":"2018","journal-title":"Int J Surg"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ijrobp.2009.09.026","article-title":"Local Response and Impact on Survival After Local Ablation of Liver Metastases From Colorectal Carcinoma by Computed Tomography\u2013Guided High-Dose-Rate Brachytherapy","volume":"78","author":"J Ricke","year":"2010","journal-title":"Int J Radiat Oncol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1186\/s12885-018-4784-9","article-title":"Local ablation or radioembolization of colorectal cancer metastases: comorbidities or older age do not affect overall survival","volume":"18","author":"R Seidensticker","year":"2018","journal-title":"BMC Cancer"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4360","DOI":"10.1016\/j.clnu.2021.01.010","article-title":"Cut-off values of skeletal muscle index and psoas muscle index at L3 vertebra level by computerized tomography to assess low muscle mass","volume":"40","author":"G Bahat","year":"2021","journal-title":"Clin Nutr"},{"key":"ref19","first-page":"11","article-title":"Skeletal muscle: an endocrine organ","volume":"10","author":"A Pratesi","year":"2013","journal-title":"Clin CASES Miner BONE Metab"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/SPC.0000000000000382","article-title":"Preservation of muscle mass as a strategy to reduce the toxic effects of cancer chemotherapy on body composition","volume":"12","author":"F Pin","year":"2018","journal-title":"Curr Opin Support Palliat Care"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.ejso.2018.09.026","article-title":"Sarcopenia is an independent unfavorable prognostic factor of non-small cell lung cancer after surgical resection: A comprehensive systematic review and meta-analysis","volume":"45","author":"H-Y Deng","year":"2019","journal-title":"Eur J Surg Oncol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.12998\/wjcc.v8.i7.1188","article-title":"Sarcopenia in patients with colorectal cancer: A comprehensive review","volume":"8","author":"O Vergara-Fernandez","year":"2020","journal-title":"World J Clin Cases"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10147-020-01805-8","article-title":"Impact of sarcopenia in patients with advanced or recurrent colorectal cancer treated with regorafenib","volume":"26","author":"Y Murachi","year":"2021","journal-title":"Int J Clin Oncol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/bjs.7823","article-title":"Body composition and outcome in patients undergoing resection of colorectal liver metastases19","volume":"99","author":"M G van Vledder","year":"2012","journal-title":"Br J Surg"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1007\/s00384-021-03839-4","article-title":"Sarcopenia predicts worse postoperative outcomes and decreased survival rates in patients with colorectal cancer: a systematic review and meta-analysis","volume":"36","author":"M Trejo-Avila","year":"2021","journal-title":"Int J Colorectal Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1477-2574.2011.00301.x","article-title":"Sarcopenia negatively impacts short-term outcomes in patients undergoing hepatic resection for colorectal liver metastasis","volume":"13","author":"P D Peng","year":"2011","journal-title":"HPB"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/hpb.12373","article-title":"Are sarcopenia, obesity and sarcopenic obesity predictive of outcome in patients with colorectal liver metastases?","volume":"17","author":"T M Lodewick","year":"2015","journal-title":"HPB (Oxford)"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1007\/s11605-013-2348-5","article-title":"Impact of Sarcopenia on Outcomes Following Intra-arterial Therapy of Hepatic Malignancies","volume":"17","author":"R M Dodson","year":"2013","journal-title":"J Gastrointest Surg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/hepr.13331","article-title":"Skeletal muscle volume loss during transarterial chemoembolization predicts poor prognosis in patients with hepatocellular carcinoma","volume":"49","author":"M Fujita","year":"2019","journal-title":"Hepatol Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.3390\/cancers11101503","article-title":"Sarcopenia Is a Negative Prognostic Factor in Patients Undergoing Transarterial Chemoembolization (TACE) for Hepatic Malignancies","volume":"11","author":"S H Loosen","year":"2019","journal-title":"Cancers"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00535-014-0964-9","article-title":"Skeletal muscle depletion is an independent prognostic factor for hepatocellular carcinoma","volume":"50","author":"S Iritani","year":"2015","journal-title":"J Gastroenterol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jhep.2015.02.031","article-title":"Sarcopenia, intramuscular fat deposition, and visceral adiposity independently predict the outcomes of hepatocellular carcinoma","volume":"63","author":"N Fujiwara","year":"2015","journal-title":"J Hepatol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2147\/JHC.S300680","article-title":"Impact of Sarcopenia on Two-Year Mortality in Patients with HCV-Associated Hepatocellular Carcinoma After Radiofrequency Ablation","volume":"8","author":"A Salman","year":"2021","journal-title":"J Hepatocell Carcinoma"}],"container-title":["R\u00f6Fo - Fortschritte auf dem Gebiet der R\u00f6ntgenstrahlen und der bildgebenden Verfahren"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1936-2937.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:51:59Z","timestamp":1676595119000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1936-2937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,25]]},"references-count":33,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2023,2,16]]},"published-print":{"date-parts":[[2023,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1936-2937","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1438-9029","1438-9010"],"issn-type":[{"value":"1438-9029","type":"print"},{"value":"1438-9010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,25]]}}}