{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:31:11Z","timestamp":1785796271233,"version":"3.56.0"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background Diabetes mellitus is a highly prevalent condition that affects\n                    people of all ages, races, and genders. Medicinal herbs have received a lot of\n                    attention from researchers, and they have suggested it to be a good adjuvant to\n                    oral diabetes medications because of their combined effects.<\/jats:p><jats:p>\n          Objectives The purpose of this systematic review is to summarize the\n                    available evidences and literature of Randomized Control Trials (RCTs) on\n                        Nigella sativa (NS) in the management of Type 2 Diabetes Mellitus\n                    (T2DM).<\/jats:p><jats:p>\n          Methods A computerised database search was performed to obtain the\n                    relevant clinical trial studies. We searched the following PubMed and Google\n                    Scholar databases. Randomized controlled trials (RCTs) comparing NS versus any\n                    treatment for the management of T2DM in adults were eligible for inclusion.<\/jats:p><jats:p>\n          Results A total of 7 articles were retrieved for interpretation, complete\n                    assessment and data extraction in this systematic review. This systematic review\n                    seeks to give thorough information on the effects of NS on glucose and insulin\n                    profile status in patients with T2DM.<\/jats:p><jats:p>\n          Interpretation &amp; Conclusion Different mechanisms are proposed\n                    which contribute to the anti-diabetic activity of NS. Various outcome parameters\n                    evaluated demonstrate a significant improvement in the management of T2DM and\n                    its complications upon intervention with NS.<\/jats:p>","DOI":"10.1055\/a-1936-8412","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T23:44:41Z","timestamp":1664322281000},"page":"17-22","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Nigella Sativa in Improving Blood Glucose Level in\n                    T2DM: Systematic Literature Review of Randomized Control Trials"],"prefix":"10.1055","volume":"73","author":[{"given":"Farazul","family":"Hoda","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Education and\n                    Research, Jamia Hamdard, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afifa","family":"Khanam","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Education and\n                    Research, Jamia Hamdard, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehak","family":"Thareja","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Education and\n                    Research, Jamia Hamdard, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mawrah","family":"Arshad","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Education and\n                    Research, Jamia Hamdard, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd","family":"Ahtar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Education and\n                    Research, Jamia Hamdard, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abul Kalam","family":"Najmi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Education and\n                    Research, Jamia Hamdard, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.psychres.2018.09.037","article-title":"Prevalence of depression among type 2 diabetes mellitus patients in India: A\n                    meta-analysis","volume":"270","author":"S Hussain","year":"2018","journal-title":"Psychiatry research"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s11695-020-05155-2","article-title":"Impact of bariatric surgery in reducing macrovascular complications in severely\n                    obese T2DM patients","volume":"31","author":"S Hussain","year":"2021","journal-title":"Obesity Surgery"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrendo.2017.151","article-title":"Global etiology and epidemiology of type 2 diabetes mellitus and its\n                    complications","volume":"14","author":"Y Zheng","year":"2018","journal-title":"Nature reviews endocrinology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.diabres.2017.03.024","article-title":"IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and\n                    2040","volume":"128","author":"K Ogurtsova","year":"2017","journal-title":"Diabetes research and clinical practice"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.2337\/db16-0766","article-title":"Type 2 diabetes: demystifying the global epidemic","volume":"66","author":"R Unnikrishnan","year":"2017","journal-title":"Diabetes."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0168-8227(01)00365-5","article-title":"Report of the Committee on the classification and diagnostic criteria of\n                    diabetes mellitus","volume":"55","author":"T Kuzuya","year":"2002","journal-title":"Diabetes research and clinical practice"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2337\/diab.46.1.3","article-title":"Role of fatty acids in the pathogenesis of insulin resistance and NIDDM","volume":"46","author":"G. 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