{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:14:02Z","timestamp":1768824842569,"version":"3.49.0"},"reference-count":48,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Aims We evaluated the clinical value of selected serum biomarkers BMP-4,\n                    BMP-2, GDF-15, MMP-9, and GP39 in pregnant women with obesity and the\n                    comorbidities diabetes mellitus (DM) and gestational hypertension (GHT).<\/jats:p><jats:p>\n          Methods This observational study had groups of controls, including healthy\n                    pregnant women; women with only obesity, including pregnant women with\n                        BMI\u226530\u2009kg\/m2; women with gestational DM\n                    (GDM) with obesity, including pregnant women with GDM and obesity; women with\n                    pregestational DM (PGDM) with obesity, including pregnant women with PGDM and\n                    obesity; and women with GHT with obesity, including pregnant women with GHT and\n                    obesity. We measured serum levels of selected biomarkers by ELISA.<\/jats:p><jats:p>\n          ResultsObesity increased serum levels of all the biomarkers; GDM developed\n                    in obese women caused a more pronounced increase in the serum levels of BMP-4\n                    and BMP-2, and GHT developed in obese women caused a more pronounced increase in\n                    the serum levels of GDF-15. In the women with GDM-, PGDM-, and GHT-complicated\n                    obesity, serum levels of MMP-9 and GP39 did not change meaningfully.<\/jats:p><jats:p>\n          Conclusions Obesity and its comorbidities DM and GHT lead to meaningful\n                    changes in the studied serum biomarkers. Since obesity has a causal effect on\n                    developing numerous conditions, reliable clinical biomarkers are needed to\n                    improve the early prediction and diagnosis of high-risk conditions during\n                    pregnancy.<\/jats:p>","DOI":"10.1055\/a-1937-1155","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T22:51:20Z","timestamp":1664405480000},"page":"42-50","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Value of Serum BMP-4, BMP-2, GDF-15, MMP-9, GP39 Levels in\n                    Pregnant Women with Obesity and the Related Comorbidities Diabetes Mellitus and\n                    Gestational Hypertension"],"prefix":"10.1055","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4577-3368","authenticated-orcid":false,"given":"Filiz","family":"Yarsilikal Guleroglu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Haseki Training and Research\n                    Hospital, Health Sciences University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0182-8988","authenticated-orcid":false,"given":"Esra","family":"Selvi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Basaksehir Cam ve Sakura City\n                    Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1666-0452","authenticated-orcid":false,"given":"Isil","family":"Turan Bakirci","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bursa City Hospital, Bursa,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4133-2477","authenticated-orcid":false,"given":"Olgu","family":"Bafal\u0131","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Haseki Training and Research\n                    Hospital, Health Sciences University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0432-8786","authenticated-orcid":false,"given":"Hatice","family":"Argun Atalmis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Haseki Training and Research\n                    Hospital, Health Sciences University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5863-1986","authenticated-orcid":false,"given":"Merve","family":"Yasti Dayan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Haseki Training and Research\n                    Hospital, Health Sciences University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1787-2692","authenticated-orcid":false,"given":"Aliye","family":"Balkan Ozmen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sivas Cumhuriyet University\n                    Faculty of Medicine, Sivas, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4725-043X","authenticated-orcid":false,"given":"Nazan","family":"Yurtcu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Haseki Training and Research Hospital,\n                    Health Sciences University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6190-3727","authenticated-orcid":false,"given":"Busra","family":"Seker Atas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Haseki Training and Research\n                    Hospital, Health Sciences University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0761-473X","authenticated-orcid":false,"given":"Esma","family":"Ozdemir Anayurt","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Haseki Training and Research Hospital,\n                    Health Sciences University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5767-7894","authenticated-orcid":false,"given":"Ali","family":"Cetin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Haseki Training and Research\n                    Hospital, Health Sciences University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1111\/obr.12288","article-title":"Risks associated with obesity in pregnancy, for the mother and baby: a\n                    systematic review of reviews","volume":"16","author":"J Marchi","year":"2015","journal-title":"Obes Rev an Off J Int Assoc Study Obes"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.3390\/ijerph19042063","article-title":"Predictors of adverse pregnancy outcomes in pregnant women living with obesity:\n                    a systematic review","volume":"19","author":"R Fakhraei","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1210\/jc.2013-2684","article-title":"ATLANTIC-DIP: excessive gestational weight gain and pregnancy outcomes in 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