{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T16:04:09Z","timestamp":1776960249604,"version":"3.51.4"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective Although the etiopathogenesis of preeclampsia (PE) is unknown,\n                    evidence suggests that it may be associated with increased oxidative stress.\n                    Studies have shown that oxidative stress can affect DNA fragments called\n                    telomeres. However, the interactions of PE, oxidative stress, and telomere\n                    length are not clearly known. This study aims to evaluate the\n                    oxidative\/anti-oxidative stress balance in the placenta and umbilical\n                    cord and examine the effect of oxidative stress on telomeres.<\/jats:p><jats:p>\n          Materials-Method Cord blood and placental samples were collected from 27\n                    pregnant women with severe PE\n                        (280\/7\u2013336\/7 gestational\n                    weeks) and 53 healthy pregnant women. Telomere length (TL) was measured by\n                    real-time PCR in the cord blood and placenta tissue. Total antioxidant status\n                    (TAS) and total oxidant status (TOS) levels were measured in the cord blood and\n                    placenta tissue using a colorimetric method.<\/jats:p><jats:p>\n          Results No significant differences were found between groups regarding\n                    age, BMI, gravida, parity, and newborn gender (p&gt;0.05). Cord blood and\n                    placental TL of PE patients were significantly shorter than the control group,\n                    while cord blood and placental TAS and TOS levels were higher (p&lt;0.05).\n                    The results of a multivariate logistic regression analysis showed that the level\n                    of placental TOS in PE patients (OR=1.212, 95%\n                    CI=1.068\u20131.375) was an independent risk factor affecting PE.<\/jats:p><jats:p>\n          Conclusion This study found that oxidative stress is an independent risk\n                    factor in the development of PE and shortens TL in both placental and umbilical\n                    cord blood. Future research on telomere homeostasis may offer a new perspective\n                    for the treatment of PE.<\/jats:p>","DOI":"10.1055\/a-1938-0010","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T23:42:10Z","timestamp":1665445330000},"page":"112-119","source":"Crossref","is-referenced-by-count":9,"title":["Placental and Umbilical Cord Blood Oxidative Stress Level and\n                    Telomere Homeostasis in Early Onset Severe Preeclampsia"],"prefix":"10.1055","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3828-9631","authenticated-orcid":false,"given":"Emre","family":"Baser","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Yozgat Bozok University,\n                    Yozgat, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihal","family":"Inandiklioglu","sequence":"additional","affiliation":[{"name":"Medical Biology, Bozok University Faculty of Medicine, Yozgat, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7849-8214","authenticated-orcid":false,"given":"Demet","family":"Aydogan K\u0131rm\u0131z\u0131","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Yozgat Bozok Universty,\n                    Medicine of Faculty, Yozgat, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2175-5405","authenticated-orcid":false,"given":"Fedi","family":"Ercan","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Necmettin Erbakan Universitesi Meram Tip\n                    Fakultesi, Konya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fen","family":"Caniklio\u011flu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Yozgat Bozok University, Faculty of\n                    Medicine, Yozgat, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Kara","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Ahi Evran University Faculty of Medicine,\n                    Kirsehir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8920-1444","authenticated-orcid":false,"given":"Taylan","family":"Onat","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Yozgat Bozok University,\n                    Faculty of Medicine, Yozgat, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethem Serdar","family":"Yalvac","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Yozgat Bozok University,\n                    Faculty of Medicine, Yozgat, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"E A Steegers","year":"2010","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"13043","DOI":"10.3390\/ijms160613043","article-title":"A proposed molecular mechanism of high-dose vitamin d3 supplementation in\n                    prevention and treatment of preeclampsia","volume":"16","author":"P Zabul","year":"2015","journal-title":"Int J Mol Sci"},{"key":"ref3","first-page":"283","article-title":"Racial\/ethnic differences in pregnancy-related hypertensive disease in\n                    nulliparous women","volume":"24","author":"G Ghosh","year":"2014","journal-title":"Ethn 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Pathol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1152\/physiolgenomics.00042.2018","article-title":"Fetal growth restriction shortens cardiac telomere length, but this is\n                    attenuated by exercise in early life","volume":"50","author":"S A Booth","year":"2018","journal-title":"Physiological genomics"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.earlhumdev.2014.06.003","article-title":"Telomere shortening in intrauterine growth restriction placentas","volume":"90","author":"T Biron-Shental","year":"2014","journal-title":"Early Hum Dev"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1938-0010.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T16:25:29Z","timestamp":1730823929000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1938-0010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,10]]},"references-count":37,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2023,4,13]]},"published-print":{"date-parts":[[2023,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1938-0010","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"value":"0948-2393","type":"print"},{"value":"1439-1651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,10]]}}}