{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:59:38Z","timestamp":1773021578049,"version":"3.50.1"},"reference-count":44,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Facial Plast Surg"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Essential oils (EOs) have been considered as a potential alternative therapy for wound healing and scar reduction. The aim of this article was to provide a comprehensive review examining the effects of EOs on wound healing and scars. PubMed, Cochrane, Ovid, and Embase computerized searches were performed through June 2020. Two independent reviewers conducted data extraction, with search results reviewed by the senior author following the PRISMA protocol. Three manuscripts examining three different EO-containing topical agents were analyzed. Outcomes include healing rate, erythema, pain, pruritus, patient discomfort, physician satisfaction, percent wound reduction, wound\/scar surface perimeter area, and qualitative dermatological evaluation. All articles concluded that the EO-containing topical agents resulted in either superior or noninferior outcomes in comparison with controls. Hypericum\u2013Calendula oil obtained lower wound surface perimeter area. Erythema (p\u2009=\u20090.001) was significantly decreased by the peppermint EO\u2013containing topical agent. Physicians also reported greater satisfaction (p\u2009&lt;\u20090.001) in wound appearance with use of the peppermint EO\u2013containing topical agent. A paucity of studies have examined EO use for wound healing and scar reduction. Treatment with EO-containing topical agents resulted in decreased erythema with increased physician satisfaction of wound appearance. Future studies should assess what level of purity is needed for improved results and which EO, or combination of EOs, is most beneficial.<\/jats:p>","DOI":"10.1055\/a-1938-0343","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T23:00:55Z","timestamp":1662591655000},"page":"173-179","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Essential Oils on Scars and Wound Healing: A Systematic Review"],"prefix":"10.1055","volume":"39","author":[{"given":"James C.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Northwestern Medicine, Chicago, Illinois"},{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Texas Tech University Health Sciences Center, Lubbock, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Callie L.","family":"Fort","sequence":"additional","affiliation":[{"name":"School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina M.","family":"Matl","sequence":"additional","affiliation":[{"name":"School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bailey D.","family":"Harvey","sequence":"additional","affiliation":[{"name":"School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua C.","family":"Demke","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Texas Tech University Health Sciences Center, Lubbock, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Regan","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Northwestern Medicine, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas M.","family":"Sidle","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Northwestern Medicine, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3928\/0090-4481-20010401-10","article-title":"New developments in wound care for infants and children","volume":"30","author":"I C Valencia","year":"2001","journal-title":"Pediatr Ann"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/00004630-198805000-00017","article-title":"Pruritus in burns: a descriptive study","volume":"9","author":"L Bell","year":"1988","journal-title":"J Burn Care 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W\u00f6lfle","year":"2014","journal-title":"Planta Med"},{"issue":"02","key":"ref26","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jep.2009.10.011","article-title":"Investigations on the in vivo wound healing potential of Hypericum perforatum L","volume":"127","author":"I P S\u00fcntar","year":"2010","journal-title":"J Ethnopharmacol"},{"issue":"01","key":"ref27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/08941939.2018.1474980","article-title":"Evaluation of the effect of topical Hypericum perforatum oil on excisional palatal wound healing in rabbits","volume":"33","author":"S Gunpinar","year":"2020","journal-title":"J Invest Surg"},{"issue":"02","key":"ref28","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1007\/s11033-019-04672-3","article-title":"Calendula arvensis L. as an anti-cancer agent against breast cancer cell lines","volume":"46","author":"N Abutaha","year":"2019","journal-title":"Mol Biol 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