{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T15:25:52Z","timestamp":1772033152604,"version":"3.50.1"},"reference-count":79,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003Detailed and decisive information about the patients' coagulation status is important in various emergency situations. Conventional global coagulation testing strategies are often used to provide a quick overview, but several limitations particularly in the trauma setting are well described. With the introduction of direct oral anticoagulations (DOACs), a milestone for several disease entities resulting in overall improved outcomes could be reached, but at the same time providing new diagnostic challenges for the emergency situation.<\/jats:p><jats:p>\n          Design\u2003As an alternative to conventional coagulation tests, there is increasing clinical and scientific interest in the use of early whole blood strategies to provide goal-directed coagulation therapies (GDCT) and hemostatic control in critically ill patients. Viscoelastic hemostatic assays (VHAs) were therefore introduced to several clinical applications and may provide as a bedside point-of-care method for faster information on the underlying hemostatic deficiency.<\/jats:p><jats:p>\n          Conclusion\u2003The use of VHA-based algorithms to guide hemostatic control in emergency situations now found its way to several international guidelines for patients at risk of bleeding. With this qualitative review, we would like to focus on VHA-based GDCT and review the current evidence for its use, advantages, and challenges in the two different clinical scenarios of trauma and intracerebral bleeding\/stroke management.<\/jats:p>","DOI":"10.1055\/a-1938-1984","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T23:30:11Z","timestamp":1671751811000},"page":"400-408","source":"Crossref","is-referenced-by-count":6,"title":["Global Coagulation Testing in Acute Care Medicine: Back to Bedside?"],"prefix":"10.1055","volume":"42","author":[{"given":"Michael","family":"Caspers","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Institute for Research in Operative Medicine, Faculty of Health, Witten\/Herdecke University, Cologne, Germany"},{"name":"Department of Traumatology, Orthopaedic Surgery and Sports Traumatology, Cologne-Merheim Medical Centre (CMMC), Witten\/Herdecke University, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes Fabian","family":"Holle","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cologne-Merheim Medical Centre (CMMC), Witten\/Herdecke University, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Limper","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, Cologne-Merheim Medical Centre (CMMC), Witten\/Herdecke University, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Fr\u00f6hlich","sequence":"additional","affiliation":[{"name":"Department of Traumatology, Orthopaedic Surgery and Sports Traumatology, Cologne-Merheim Medical Centre (CMMC), Witten\/Herdecke University, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertil","family":"Bouillon","sequence":"additional","affiliation":[{"name":"Department of Traumatology, Orthopaedic Surgery and Sports Traumatology, Cologne-Merheim Medical Centre (CMMC), Witten\/Herdecke University, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3171\/2010.7.JNS091857","article-title":"Prophylactic correction of the international normalized ratio in neurosurgery: a brief review of a brief literature","volume":"114","author":"K L West","year":"2011","journal-title":"J Neurosurg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1053\/j.jvca.2013.05.012","article-title":"Diagnosis of perioperative coagulopathy \u2013 plasma versus whole blood testing","volume":"27","author":"K A Tanaka","year":"2013","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1097\/TA.0b013e3182a9676c","article-title":"The International Normalized Ratio overestimates coagulopathy in stable trauma and surgical patients","volume":"75","author":"S P McCully","year":"2013","journal-title":"J Trauma Acute Care Surg"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/bja\/aer342","article-title":"Comparison of thromboelastometry (ROTEM\u00ae) with standard plasmatic coagulation testing in paediatric surgery","volume":"108","author":"T Haas","year":"2012","journal-title":"Br J Anaesth"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13054-015-0823-y","article-title":"Detection of acute traumatic coagulopathy and massive transfusion requirements by means of rotational thromboelastometry: an international prospective validation study","volume":"19","author":"J S Hagemo","year":"2015","journal-title":"Crit Care"},{"issue":"09","key":"ref6","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1111\/j.1537-2995.2005.00546.x","article-title":"Paucity of studies to support that abnormal coagulation test results predict bleeding in the setting of invasive procedures: an evidence-based review","volume":"45","author":"J B Segal","year":"2005","journal-title":"Transfusion"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/bja\/aeu303","article-title":"Usefulness of standard plasma coagulation tests in the management of perioperative coagulopathic bleeding: is there any evidence?","volume":"114","author":"T Haas","year":"2015","journal-title":"Br J Anaesth"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13049-018-0536-8","article-title":"How do external factors contribute to the hypocoagulative state in trauma-induced coagulopathy? 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