{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:46:00Z","timestamp":1790019960977,"version":"4.0.1"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Postoperative rhabdomyolysis (RML) has been documented after several surgical procedures in adults. Musculoskeletal remodeling after Nuss procedure for pectus excavatum (PE) could cause RML. We evaluated the incidence of RML after Nuss procedure in children.<\/jats:p><jats:p>\n          Methods\u2003This study was a prospective study from 2018 to 2021. We enrolled all otherwise healthy patients who underwent PE correction with only one bar. Studied variables included demographic and clinical data, duration of surgery, complications, and length of hospitalization. The patients included underwent serial measurements of serum creatine kinase (CK), troponin I, N terminal pro B-type natriuretic peptide (NT-proBNP), serum creatinine, urea, and glomerular filtration rate at 6 and 48\u2009hours postoperatively, and hospital discharge.<\/jats:p><jats:p>\n          Results\u2003Forty-six patients met criteria (40 males\/6 females), with a mean age of 15.1\u2009\u00b1\u20091.4 years. Mean duration of surgery was 74\u2009\u00b1\u200928\u2009minutes, and length of hospitalization was 4.6\u2009\u00b1\u20091.6 days. RML was diagnosed in 30.4% of patients at 6\u2009hours, 91.3% at 48\u2009hours, and 21.7% at hospital discharge. Mean preoperative CK value was 181.1\u2009\u00b1\u2009141.6\u2009IU\/L, and postoperative values were 863.3\u2009\u00b1\u2009302.6\u2009IU\/L at 6\u2009hours, 1,675.2\u2009\u00b1\u2009561\u2009IU\/L at 48\u2009hours, and 850\u2009\u00b1\u2009683.7\u2009IU\/L at hospital discharge, with statistically significant differences (p\u2009=\u20090.001). High-sensitivity troponin I and NT-proBNP levels increased significantly during the postoperative time (p\u2009=\u20090.001). Renal function remained stable (p\u2009=\u20090.55).<\/jats:p><jats:p>\n          Conclusion\u2003Nuss technique produces RML without kidney injury in healthy patients. This knowledge should be considered for patients at increased risk of developing acute kidney injury and other complications.<\/jats:p>","DOI":"10.1055\/a-1939-3891","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T23:17:40Z","timestamp":1662679060000},"page":"035-040","source":"Crossref","is-referenced-by-count":1,"title":["Rhabdomyolysis following Nuss Procedure: A Prospective Study in Children"],"prefix":"10.1055","volume":"33","author":[{"given":"Karla","family":"Estefan\u00eda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Serradilla","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3997-2291","authenticated-orcid":false,"given":"Maria","family":"Velayos","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0073-9425","authenticated-orcid":false,"given":"Antonio Jesus","family":"Mu\u00f1oz-Serrano","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Department of 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