{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T04:27:31Z","timestamp":1692851251529},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Was ist neu?<\/jats:title><jats:p>\n            Aktuelle Therapie. Die Einhaltung einer strikten Alkoholabstinenz, eine Optimierung des Ern\u00e4hrungsstatus, die Vermeidung von Infektionen sowie die Gabe von Kortikosteroiden sind derzeit die Hauptpfeiler der Behandlung von Patienten mit Alkoholischer Hepatitis (AH).<\/jats:p><jats:p>\n            Neue Therapieans\u00e4tze. Infolge eines verbesserten Verst\u00e4ndnisses der zugrundeliegenden Pathomechanismen der AH werden derzeit eine Vielzahl neuer, innovativer Therapiemethoden in klinischen Studien untersucht, welche das Potenzial aufweisen, das Outcome der Betroffenen zu verbessern und die hohe Kurzzeitmortalit\u00e4t dieser Erkrankung zu reduzieren. Neue Ans\u00e4tze umfassen die Applikation anti-inflammatorischer Substanzen (z.B. Interleukin-1-Inhibitoren), Modifikationen der Darm-Leber-Achse via f\u00e4kalem Mikrobiomtransfer oder der Gabe nicht resorbierbarer Antibiotika (z.B. Rifaximin), sowie Medikamente zur Steigerung der hepatischen Regeneration (z.B. Interleukin-22-Agonisten). Zudem stellen Medikamente, die oxidativen Stress reduzieren k\u00f6nnen (z.B. N-Acetylcystein, Metadoxine), weitere therapeutische Strategien dar. Mittlerweile konnten au\u00dferdem mehrere Studien zeigen, dass eine fr\u00fchzeitige Lebertransplantation als Rescue-Therapie f\u00fcr ausgew\u00e4hlte Patienten mit schwerer AH, die nicht auf eine Steroidbehandlung ansprachen, eine sinnvolle Option darstellen kann und mit einem deutlichen \u00dcberlebensvorteil und gutem Outcome einhergeht.<\/jats:p>","DOI":"10.1055\/a-1941-7187","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T22:30:52Z","timestamp":1692829852000},"page":"1095-1101","source":"Crossref","is-referenced-by-count":0,"title":["Alkoholische Hepatitis \u2013 Aktuelle und zuk\u00fcnftige Behandlungskonzepte"],"prefix":"10.1055","volume":"148","author":[{"given":"Philipp","family":"Kasper","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gastroenterologie und Hepatologie, Universit\u00e4tsklinikum K\u00f6ln, K\u00f6ln, 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