{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:21:03Z","timestamp":1790803263991,"version":"4.1.0"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"The First Hospital of Jilin University","award":["2020-ZL-07"],"award-info":[{"award-number":["2020-ZL-07"]}]},{"name":"Science and Technology Department of Jilin Province Fund","award":["20200404162YY\uff0c20210101279JC,20190201201JC"],"award-info":[{"award-number":["20200404162YY\uff0c20210101279JC,20190201201JC"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82171023"],"award-info":[{"award-number":["82171023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Bethune Center for Medical Engineering and Instrumentation","award":["BQEGCZX20210XX"],"award-info":[{"award-number":["BQEGCZX20210XX"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background This retrospective study aimed to evaluate the effect of intense pulsed light treatment (IPL) combined with meibomian gland expression (MGX) in treating meibomian gland\n          dysfunction (MGD) related dry eye disease (DED) for the first time in Northeast China.<\/jats:p><jats:p>\n          Methods Thirty-one MGD-related dry eye patients were managed by IPL-MGX from October to December 2019 in The First Hospital of Jilin University. Those patients had single IPL-MGX\n          treatment with one follow-up visit, and no topical eye drops used were included in the study. General checkup and data collection helped in determining the age, sex, diagnosis, status of the\n          MG, first noninvasive tear break-up time (1st NIBUT), average NIBUT, the height of tear film, and additional medical history.<\/jats:p><jats:p>\n          Results There was an improvement in the function of the meibomian gland (MG), with a significant decrease in the MG dropouts in the upper eyelid (Rt eye, p\u2009=\u20090.0047; Lt eye,\n          p\u2009=\u20090.0158) and lower eyelid (Rt eye, p\u2009=\u20090.0017; Lt eye, p\u2009=\u20090.0027) plus the average NIBUT (Rt eye, p\u2009=\u20090.0264) also showed improvement after the IPL-MGX treatment. Though no significant\n          difference was reached with the average NIBUT of the Lt eye (p\u2009=\u20090.5256) and the NIBUT grade (Rt eye, p\u2009=\u20090.0578; Lt eye, p\u2009=\u20090.0588), there was an increased duration of the average NIBUT\n          and improved NIBUT grading. The negative results may be because of the maximum severity of DED and the limited treatment times.<\/jats:p><jats:p>\n          Conclusions The result suggests that IPL-MGX was effective in treating MGD-related DED.<\/jats:p>","DOI":"10.1055\/a-1942-2007","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:16:50Z","timestamp":1663114610000},"page":"163-168","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Intense Pulsed Light to Mitigate Meibomian Gland Dysfunction for Dry Eye Disease"],"prefix":"10.1055","volume":"240","author":[{"given":"Abhishek","family":"Suwal","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilong","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufen","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Radiology, The First Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifang","family":"Jia","sequence":"additional","affiliation":[{"name":"Division of Clinical Research, The First Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Ophthalmology, Jiamusi University First Affiliated Hospital, Jiamusi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4335-4813","authenticated-orcid":false,"given":"Chengwei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,11,27]]},"reference":[{"key":"ref1","first-page":"872","article-title":"[Meibomian glands. 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Schaumberg","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1167\/iovs.10-6997d","article-title":"The international workshop on meibomian gland dysfunction: report of the subcommittee on tear film lipids and lipid-protein interactions in health and disease","volume":"52","author":"K B Green-Church","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e105575","DOI":"10.1371\/journal.pone.0105575","article-title":"Meibomian gland dysfunction determines the severity of the dry eye conditions in visual display terminal workers","volume":"9","author":"H Wu","year":"2014","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41377-021-00630-6","article-title":"Air pollution and meteorological conditions significantly contribute to the worsening of allergic conjunctivitis: a regional 20-city, 5-year study in Northeast China","volume":"10","author":"C W Lu","year":"2021","journal-title":"Light Sci Appl"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1089\/photob.2020.4826","article-title":"Intense Pulsed Light Treatment for Itch Associated with Allergic Keratoconjunctivitis: A Retrospective Study of 35 Cases","volume":"39","author":"D Li","year":"2021","journal-title":"Photobiomodul Photomed Laser Surg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1167\/iovs.14-15764","article-title":"Prospective trial of intense pulsed light for the treatment of meibomian gland dysfunction","volume":"56","author":"J P Craig","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1080\/02713683.2017.1406525","article-title":"Changes in the Meibomian Gland After Exposure to Intense Pulsed Light in Meibomian Gland Dysfunction (MGD) Patients","volume":"43","author":"Y Yin","year":"2018","journal-title":"Curr Eye Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1097\/ICO.0000000000001687","article-title":"Multicenter Study of Intense Pulsed Light Therapy for Patients With Refractory Meibomian Gland Dysfunction","volume":"37","author":"R Arita","year":"2018","journal-title":"Cornea"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/eye.2010.228","article-title":"The relationship between clinical signs and dry eye symptoms","volume":"25","author":"H Pult","year":"2011","journal-title":"Eye (Lond)"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jtos.2018.11.004","article-title":"Therapeutic efficacy of intense pulsed light in patients with refractory meibomian gland dysfunction","volume":"17","author":"R Arita","year":"2019","journal-title":"Ocul Surf"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1942-2007.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:25:00Z","timestamp":1677111900000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1942-2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,13]]},"references-count":19,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2023,2,22]]},"published-print":{"date-parts":[[2023,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1942-2007","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"value":"0023-2165","type":"print"},{"value":"1439-3999","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9,13]]},"published":{"date-parts":[[2022,9,13]]}}}