{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:38:24Z","timestamp":1776109104310,"version":"3.50.1"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction Uromodulin is a kidney-specific tubular protein, and its\n                    assessment in serum (sUMOD) reveals the potential as a novel marker for function\n                    and the integrity of renal parenchymal cells and does not directly depend on the\n                    glomerular filtration rate. Early diabetic nephropathy parallels glomerular\n                    hyperfiltration, often leading to diagnostic misinterpretation. Moreover,\n                    traditional kidney function markers are not able to diagnose structural lesions.\n                    Recent data show that sUMOD is linked to glucose intolerance in adults. Thus, we\n                    launched to assess the hypothesis that sUMOD is also associated with kidney\n                    function, biometric data, and quality of metabolic control in\n                    children\/adolescents with type 1 diabetes.<\/jats:p><jats:p>\n          Patients and methods Patients with type 1 diabetes (n=135) and\n                    healthy controls (n=69) were recruited to participate in the trial.\n                    Clinical, biometrical data, sUMOD, and other laboratory parameters were\n                    assessed.<\/jats:p><jats:p>\n          Results The mean concentrations of sUMOD in diabetic patients and controls\n                    were comparable (201.19\u00b1103.22 vs.\n                    198.32\u00b184.27\u2009ng\/mL, p=0.832). However, in\n                    contrast to healthy controls, sUMOD levels in patients with diabetes were\n                    associated with serum-creatinine (r=\u22120.368, p&lt;0.0001),\n                    age (r=\u22120.350, p&lt;0.0001), height\n                    (r=\u22120.379, p&lt;0.0001), body weight\n                    (r=\u22120.394, p&lt;0.0001), Body mass index\n                    (r=\u22120.292, p=0.001), daily insulin dosage\n                    (r=\u22120.300, p&lt;0.0001), HbA1c (%)\n                    (r=\u22120.190, p=0.027), standardized HbA1c\/IFCC\n                    (mmol\/mol) (r=\u22120.189, p=0.028), and systolic\n                    (r=\u22120.299, p&lt;0.0001) and diastolic\n                    (r=\u22120.235, p=0.006) arterial blood pressure.<\/jats:p><jats:p>\n          Conclusions Our study shows that children\/adolescents with type 1\n                    diabetes disclose similar sUMOD concentrations as healthy controls. Serum UMOD\n                    appears to indicate higher risks for kidney tissue remodeling and possibly\n                    subsequent cardiovascular alterations. However, further studies are mandatory to\n                    settle these findings.<\/jats:p>","DOI":"10.1055\/a-1944-2686","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T01:12:43Z","timestamp":1663204363000},"page":"142-152","source":"Crossref","is-referenced-by-count":8,"title":["Serum Uromodulin in Children and Adolescents with Type 1 Diabetes\n                    Mellitus and Controls: Its Potential Role in Kidney Health"],"prefix":"10.1055","volume":"131","author":[{"given":"Ralf","family":"Schiel","sequence":"additional","affiliation":[{"name":"MEDIGREIF-Inselklinik Heringsdorf GmbH, Department of Diabetes and\n                    Metabolic Diseases, Ostseebad Heringsdorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Block","sequence":"additional","affiliation":[{"name":"Euroimmun Medizinische Labordiagnostika AG, L\u00fcbeck,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje","family":"Steveling","sequence":"additional","affiliation":[{"name":"University of Greifswald, School of Medicine, Internal Medicine A,\n                    Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnter","family":"Stein","sequence":"additional","affiliation":[{"name":"Friedrich-Schiller-University, School of Medicine, Internal Medicine,\n                    Nephrology, Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"L\u00fccking","sequence":"additional","affiliation":[{"name":"MEDIGREIF-Inselklinik Heringsdorf GmbH, Department of Diabetes and\n                    Metabolic Diseases, Ostseebad Heringsdorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Scherberich","sequence":"additional","affiliation":[{"name":"Klinikum M\u00fcnchen-Harlaching, M\u00fcnchen-Klinik, Teaching\n                    Hospital of The Ludwig-Maximilians University, M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1053\/j.ajkd.2018.06.017","article-title":"Incident type 2 diabetes among individuals with CKD: Findings from the Chronic\n                    Renal Insufficiency Cohort (CRIC) Study","volume":"73","author":"C Jepson","year":"2019","journal-title":"Am J Kidney Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/nrneph.2015.173","article-title":"Changing epidemiology of type 2 diabetes mellitus and associated kidney\n                    disease","volume":"12","author":"M C Thomas","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1053\/jackd.2017.10.011","article-title":"The global epidemiology of diabetes and kidney disease","volume":"25","author":"D N Koye","year":"2018","journal-title":"Adv Chronic Kidney Dis"},{"key":"ref4","volume-title":"Nierenersatztherapie in Deutschland. 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Transl Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1093\/ndt\/gfw422","article-title":"Serum uromodulin \u2013 A marker of kidney function and renal parenchymal\n                    integrity","volume":"33","author":"J E Scherberich","year":"2018","journal-title":"Nephrol Dial Transplant"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"21 (e15808)","DOI":"10.1097\/MD.0000000000015808","article-title":"Urinary uromodulin independently predicts end-stage renal disease and rapid\n                    kindney function decline in a cohort of chronic kidney disease patients","volume":"98","author":"D Steubl","year":"2019","journal-title":"Medicine"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1097\/HJH.0000000000001527","article-title":"The value of uromodulin as a new serum marker to predict decline in renal\n                    function","volume":"36","author":"A Leiherer","year":"2018","journal-title":"J 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bioactivity of uromodulin peptides in vitro","volume":"19","author":"JA D Van","year":"2020","journal-title":"Mol Cell Proteomics"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"jc.2018","DOI":"10.1210\/jc.2018-02557","article-title":"Serum uromodulin is associated with but does not predict type 2 diabetes in\n                    elderly KORA F4\/FF4 study participants","author":"C Then","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/ndt\/gft345","article-title":"Determination of uromodulin in human urine: Influence of storage and\n                    processing","volume":"29","author":"S Youhanna","year":"2014","journal-title":"Nephrol Dial Transplant"}],"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1944-2686.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T01:11:27Z","timestamp":1678410687000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1944-2686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,14]]},"references-count":38,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2023,3,9]]},"published-print":{"date-parts":[[2023,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1944-2686","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9,14]]},"published":{"date-parts":[[2022,9,14]]}}}