{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:47:07Z","timestamp":1764154027402,"version":"3.46.0"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Hintergrund Kraniopharyngeome sind seltene embryonale Fehlbildungstumore\n                    niedriger Malignit\u00e4t. Die Langzeitprognose nach Diagnose im Kindes- und\n                    Jugendalter wird h\u00e4ufig durch (neuro)endokrine Sp\u00e4tfolgen\n                    beeintr\u00e4chtigt. Eine Anerkennung des Schwerbehindertenstatus mit\n                    unterschiedlichen Graden der Behinderung (GdB) kann die psychosoziale\n                    Integration erleichtern.<\/jats:p>\n                  <jats:p>Patienten und Methoden 108 Patienten, die mit kindlichem Kraniopharyngeom\n                    in der Studie HIT-Endo registriert wurden, konnten nach im Median 16 Jahren\n                    Follow-up hinsichtlich des aktuellen GdB und assoziierter Faktoren wie\n                    endokriner, ophthalmologischer, neuropsychologischer (QLQ-C30; MFI-20;\n                    FMH-Skala) und psychosozialer Befunde ausgewertet werden.<\/jats:p>\n                  <jats:p>Ergebnisse 47 Patienten (43%) hatten keine Anerkennung einer\n                    Behinderung oder einen GdB 30\u201340, 43 Patienten (40%) einen GdB\n                    50\u201390 und 18 Patienten (17%) einen GdB 100. H\u00f6here GdB\n                    waren assoziiert mit niedrigerem schulischen Bildungsniveau, h\u00f6herem\n                    BMI-SDS, einer h\u00f6heren Rate an Sehbeeintr\u00e4chtigungen und\n                    hypothalamischer Beteiligung des Kraniopharyngeoms. Patienten mit einem GdB 100\n                    litten h\u00e4ufiger an Einschr\u00e4nkungen der physischen und kognitiven\n                    Funktion, Atemnot und Schmerzzust\u00e4nden (QLQ-C30), sowie Fatigue\n                    (MFI-20), und Einschr\u00e4nkungen im sozialen und beruflichen Kontext.\n                    Patienten mit GdB 100 haben im Mittel eine herabgesetzte funktionelle\n                    Kapazit\u00e4t (FMH Score) gegen\u00fcber Patienten mit niedrigerem\n                    GdB.<\/jats:p>\n                  <jats:p>Schlussfolgerungen Der anerkannte GdB zeigt sich assoziiert mit\n                    psychosozialen und gesundheitlichen Einschr\u00e4nkungen im Langzeitverlauf\n                    nach Kraniopharyngeom. Die funktionelle Kapazit\u00e4t zeigt im Mittel einen\n                    gro\u00dfen Unterschied zwischen GdB 100 und niedrigerem GdB.<\/jats:p>","DOI":"10.1055\/a-1952-9994","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T19:23:57Z","timestamp":1668540237000},"page":"151-158","source":"Crossref","is-referenced-by-count":0,"title":["Anerkannter Grad der Behinderung (GdB) im Langzeitverlauf nach\n                    Kraniopharyngeom im Kindes- und Jugendalter"],"prefix":"10.1055","volume":"235","author":[{"given":"Svenja","family":"Boekhoff","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Pediatric Hematology\/Oncology,\n                    University Children\u2019s Hospital, Klinikum Oldenburg A\u00f6R, Carl von\n                    Ossietzky University Oldenburg, Oldenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Eveslage","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Clinical Research, University of\n                    M\u00fcnster, Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Beckhaus","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Pediatric Hematology\/Oncology,\n                    University Children\u2019s Hospital, Klinikum Oldenburg A\u00f6R, Carl von\n                    Ossietzky University Oldenburg, Oldenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Pediatric Hematology\/Oncology,\n                    University Children\u2019s Hospital, Klinikum Oldenburg A\u00f6R, Carl von\n                    Ossietzky University Oldenburg, Oldenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann L.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Pediatric Hematology\/Oncology,\n                    University Children\u2019s Hospital, Klinikum Oldenburg A\u00f6R, Carl von\n                    Ossietzky University Oldenburg, Oldenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30: a\n                    quality-of-life instrument for use in international clinical trials in\n                    oncology","volume":"85","author":"N K Aaronson","year":"1993","journal-title":"Journal of the National Cancer 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