{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T20:50:44Z","timestamp":1776977444329,"version":"3.51.4"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund Das kutane Plattenepithelkarzinom (kPEK) als weltweit zweith\u00e4ufigster Hauttumor ist \u00fcberwiegend an Kopf und Gesicht lokalisiert. Aufgrund der steigenden Anzahl \u00e4lterer Menschen und der dadurch zunehmenden Inzidenz gewinnt es in den letzten Jahren an Relevanz im HNO-Fachgebiet.<\/jats:p><jats:p>\n          Material und Methoden Diese \u00dcbersichtsarbeit basiert auf einer selektiven Literaturrecherche in PubMed, der deutschen und europ\u00e4ischen Leitlinie sowie klinikeigenen Erfahrungen.<\/jats:p><jats:p>\n          Ergebnisse \u00c4tiologisch ist neben der chronischen UV-Exposition eine St\u00f6rung des k\u00f6rpereigenen Abwehrsystems zunehmend bedeutend. Die vertikale Tumordicke ist mit dem h\u00f6chsten Risiko einer Metastasierung und eines Lokalrezidivs assoziiert. Weitere bedeutende Risikofaktoren sind: horizontaler Tumordurchmesser, Entdifferenzierung, Desmoplasie, perineurales Wachstum und Lokalisation im Gesicht. Zumeist ist die Exzision mit histologischer Schnittrandkontrolle als Therapie ausreichend. Bei klinischem Verdacht auf lokoregion\u00e4re Metastasen sollen je nach Lokalisation des Prim\u00e4rtumors die drainierenden zervikalen Lymphknotenlevel ausger\u00e4umt werden. kPEK der oberen Gesichtshaut und der Ohrmuschel metastasieren bevorzugt zuerst in die Glandula parotidea. Mit der Zulassung des PD-1-Antik\u00f6rpers Cemiplimab in Europa steht erstmals ein Wirkstoff zur Behandlung fortgeschrittener, chirurgisch oder durch Strahlentherapie nicht therapierbarer kPEK zur Verf\u00fcgung.<\/jats:p><jats:p>\n          Schlussfolgerungen Die grunds\u00e4tzlich sehr niedrige Mortalit\u00e4t des kPEK erh\u00f6ht sich erheblich, wenn Metastasen auftreten. Dementsprechend sollen sich bildgebende Verfahren, chirurgische Therapie und Nachsorgeintervalle an den Risikofaktoren orientieren. Hierdurch k\u00f6nnen Metastasen oder Lokalrezidive fr\u00fchzeitig erkannt und die Prognose verbessert werden.<\/jats:p>","DOI":"10.1055\/a-1953-7374","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:01:05Z","timestamp":1669939265000},"page":"186-193","source":"Crossref","is-referenced-by-count":2,"title":["Kutane Plattenepithelkarzinome im Kopf- und Halsbereich"],"prefix":"10.1055","volume":"102","author":[{"given":"Jochen","family":"Deutsch","sequence":"additional","affiliation":[{"name":"HNO-Klinik, Klinikum der Stadt Ludwigshafen am Rhein gGmbH, Ludwigshafen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Dippel","sequence":"additional","affiliation":[{"name":"Hautklinik, Klinikum der Stadt Ludwigshafen am Rhein gGmbH, Ludwigshafen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.-Wolfgang","family":"Delank","sequence":"additional","affiliation":[{"name":"HNO-Klinik, Klinikum der Stadt Ludwigshafen am Rhein gGmbH, Ludwigshafen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"60\u201382","DOI":"10.1016\/j.ejca.2020.01.007","article-title":"European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: Part 1. epidemiology, diagnostics and prevention","volume":"128","author":"AJ Stratigos","year":"2020","journal-title":"Eur J Cancer"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ejca.2020.01.008.","article-title":"European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: Part 2. 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