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The definition of AKI in cirrhosis is currently based on changes of serum creatinine levels with respect to baseline values. Differential diagnosis of the causes of AKI is of major relevance, considering that some causes of AKI, such as hepatorenal syndrome, have specific treatment options and different prognosis. Prediction of kidney function recovery and patients' survival is also crucial in this patient population to guide clinical decisions. AKI biomarkers in cirrhosis have emerged as a promising tool for differential diagnosis and prognosis in this situation. There are consistent data showing that some urine biomarkers, particularly neutrophil gelatinase-associated lipocalin, may be useful in daily clinical practice for the differential diagnosis of the cause of AKI in cirrhosis. AKI biomarkers may constitute a useful tool for use in differential diagnosis, prognosis of renal function, and survival in patients with cirrhosis. This review focuses on the current state of knowledge and future perspective of novel biomarkers of AKI in cirrhosis.<\/jats:p>","DOI":"10.1055\/a-1954-4136","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T22:44:52Z","timestamp":1664837092000},"page":"489-500","source":"Crossref","is-referenced-by-count":11,"title":["Novel Biomarkers of AKI in Cirrhosis"],"prefix":"10.1055","volume":"42","author":[{"given":"Adri\u00e0","family":"Juanola","sequence":"additional","affiliation":[{"name":"Liver Unit, Hospital Cl\u00ednic de Barcelona, University of Barcelona, Barcelona, Catalonia, Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEReHD), Barcelona, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann T.","family":"Ma","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEReHD), Barcelona, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Pose","sequence":"additional","affiliation":[{"name":"Liver Unit, Hospital Cl\u00ednic de Barcelona, University of Barcelona, Barcelona, Catalonia, Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEReHD), Barcelona, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pere","family":"Gin\u00e8s","sequence":"additional","affiliation":[{"name":"Liver Unit, Hospital Cl\u00ednic de Barcelona, University of Barcelona, Barcelona, Catalonia, Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEReHD), Barcelona, Catalonia, Spain"},{"name":"Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41572-018-0022-7","article-title":"Hepatorenal syndrome","volume":"4","author":"P Gin\u00e8s","year":"2018","journal-title":"Nat Rev Dis Primers"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.cgh.2016.09.156","article-title":"Validation of a staging system for acute kidney injury in patients with cirrhosis and association with acute-on-chronic liver failure","volume":"15","author":"P Huelin","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s12072-015-9653-x","article-title":"AKI in patients with acute on chronic liver failure is different from acute decompensation of cirrhosis","volume":"9","author":"R Maiwall","year":"2015","journal-title":"Hepatol Int"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"e00359","DOI":"10.14309\/ctg.0000000000000359","article-title":"Urinary NGAL as a diagnostic and prognostic marker for acute kidney injury in cirrhosis: a prospective study","volume":"12","author":"A S Allegretti","year":"2021","journal-title":"Clin Transl Gastroenterol"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.jhep.2020.04.043","article-title":"Changing epidemiology and outcomes of acute kidney injury in hospitalized patients with cirrhosis - 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