{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T19:10:14Z","timestamp":1713813014065},"reference-count":72,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zentralbl Chir"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Weltweit sind 40% der Erwachsenen von \u00dcbergewicht und Adipositas betroffen. Neben den bekannten adipositasassoziierten Komorbidit\u00e4ten, wie Diabetes mellitus Typ 2, arteriellem Hypertonus\n          oder der Steatosis hepatitis u.\u00a0a., r\u00fcckt der Einfluss eines erh\u00f6hten K\u00f6rpergewichts auf das Risiko maligner Erkrankungen in den Fokus. F\u00fcr mehr als 20 Tumorarten ist ein gewichtsabh\u00e4ngiger\n          Pr\u00e4valenzanstieg belegt, wobei die pathophysiologischen Einfl\u00fcsse vielf\u00e4ltig sind und unterschiedlichste Aspekte der Tumorentstehung umfassen. Hier zu nennen sind chronische\n          Entz\u00fcndungsprozesse, Hyperinsulin\u00e4mie und Insulinresistenz, verschiedene Wachstumsfaktoren und Geschlechtshormone. Auch im viszeralonkologischen Krankengut finden sich zahlreiche Tumoren,\n          deren Erkrankungsrisiko mit dem K\u00f6rpergewicht teilweise deutlich ansteigt. Dies zeigt sich u.\u00a0a. beim kolorektalen Karzinom, hepatozellul\u00e4ren Karzinom, Adenokarzinom von Pankreas und\n          \u00d6sophagus sowie beim Kardiakarzinom. Da die Adipositas als grunds\u00e4tzlich vermeidbare oder urs\u00e4chlich behandelbare Krebsursache angesehen werden muss, besch\u00e4ftigt sich diese \u00dcbersichtsarbeit\n          zum einen mit dem Einfluss einer Adipositas auf die Pr\u00e4valenz viszeralonkologisch relevanter Tumoren sowie deren Pr\u00e4vention und Therapie. Zum anderen wird die aktuelle Datenlage zum Einfluss\n          adipositaschirurgischer Eingriffe auf die Tumorpr\u00e4valenz dargestellt. Nach bariatrischen Eingriffen kann beim Adenokarzinom des Pankreas und beim hepatozellul\u00e4ren Karzinom eine deutlich\n          geringere Malignompr\u00e4valenz beobachtet werden, gerade bei Letzterem kann dieser Effekt durch den mit der Gewichtsreduktion einhergehenden R\u00fcckgang der nicht alkoholischen Fettlebererkrankung\n          (NAFLD) erkl\u00e4rt werden. Beim kolorektalen Karzinom hingegen zeigen die verf\u00fcgbaren Daten ein eher inhomogenes Bild. Bei Malignomen des \u00f6sophagealen \u00dcbergangs wiederum wird, trotz der\n          berechtigten Sorge, dass bariatrische Operationen (insbesondere die Schlauchmagenresektion) zu einer refluxbedingten erh\u00f6hten Pr\u00e4valenz von Barrett-Karzinomen f\u00fchren, keine relevante\n          Erh\u00f6hung der Malignomrate beobachtet.<\/jats:p>","DOI":"10.1055\/a-1957-5622","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T23:36:02Z","timestamp":1670456162000},"page":"574-583","source":"Crossref","is-referenced-by-count":1,"title":["Adipositas aus viszeralonkologischer Perspektive"],"prefix":"10.1055","volume":"147","author":[{"given":"Till","family":"Hasenberg","sequence":"additional","affiliation":[{"name":"Helios Adipositas Zentrum West, HELIOS Sankt Elisabeth Klinik Oberhausen, Oberhausen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Helios Adipositas Zentrum West, HELIOS Sankt Elisabeth Klinik Oberhausen, Oberhausen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1055\/s-0040-100426","article-title":"[Conservative obesity treatment \u2013 when and how?]","volume":"140","author":"M Bluher","year":"2015","journal-title":"Dtsch Med Wochenschr"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/S0140-6736(16)30054-X","article-title":"Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants","volume":"387","author":"NCDRisk Factors Collaboration 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