{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T06:04:39Z","timestamp":1668665079815},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultrasound Int Open"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose Neurosonography evaluation of neonatal hypoxic-ischemic\n                    encephalopathy (HIE) is mainly qualitative. We aimed to quantitatively compare\n                    the echogenicity of several brain regions in patients with HIE to healthy\n                    controls.<\/jats:p><jats:p>\n          Materials and Methods 20 term neonates with clinical\/MRI evidence\n                    of HIE and 20 term healthy neonates were evaluated. Seven brain regions were\n                    assessed [frontal, parietal, occipital, and perirolandic white matter (WM),\n                    caudate nucleus head, lentiform nucleus, and thalamus]. The echogenicity of the\n                    calvarial bones (bone) and the choroid plexus (CP) was used for ratio\n                    calculation. Differences in the ratios were determined between neonates with HIE\n                    and controls.<\/jats:p><jats:p>\n          Results Ratios were significantly higher for HIE neonates in each region\n                    (p&lt;0.05). The differences were greatest for the perirolandic WM, with CP\n                    and bone ratios being 0.23 and 0.22 greater, respectively, for the HIE compared\n                    to the healthy neonates (p&lt;0.001). The perirolandic WM had a high AUC,\n                    at 0.980 for both the CP and bone ratios. The intra-observer reliability for all\n                    ratios was high, with the caudate to bone ratio being the lowest at 0.832 and\n                    the anterior WM to CP ratio being the highest at 0.992.<\/jats:p><jats:p>\n          Conclusion When coupled with internal controls, quantitative\n                    neurosonography represents a potential tool to identify early neonatal HIE\n                    changes. Larger cohort studies could reveal whether a quantitative approach can\n                    discern between degrees of severity of HIE. Future neurosonography protocols\n                    should be tailored to evaluate the perirolandic region, which requires posterior\n                    coronal scanning.<\/jats:p>","DOI":"10.1055\/a-1958-3985","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T23:51:57Z","timestamp":1668642717000},"page":"E43-E52","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative Evaluation of Brain Echogenicity in Hypoxic-Ischemic\n                    Encephalopathy in Term Neonates Compared with Controls"],"prefix":"10.1055","volume":"08","author":[{"given":"Fabr\u00edcio Guimar\u00e3es","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Radiology, The Children\u2019s Hospital of Philadelphia,\n                    Philadelphia, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colbey","family":"Freeman","sequence":"additional","affiliation":[{"name":"Radiology, University of Pennsylvania Perelman School of Medicine,\n                    Philadelphia, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry","family":"Khrichenko","sequence":"additional","affiliation":[{"name":"Radiology, The Children\u2019s Hospital of Philadelphia,\n                    Philadelphia, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misun","family":"Hwang","sequence":"additional","affiliation":[{"name":"Radiology, The Children\u2019s Hospital of Philadelphia,\n                    Philadelphia, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1148\/radiographics.14.5.7991816","article-title":"Understanding the process of quantitative ultrasonic tissue\n                    characterization","volume":"14","author":"J W 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