{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T07:28:46Z","timestamp":1748503726745},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n            Einleitung Die Diagnose Pankreaskarzinom z\u00e4hlt trotz modernster Diagnose- und Therapieoptionen zu den h\u00e4ufigsten krebsbedingten globalen Todesursachen. H\u00e4ufig liegt bei diesen Patienten eine Kachexie und Sarkopenie vor.<\/jats:p><jats:p>\n            Methode In einer retrospektiven Analyse wurde die jeweilige Querschnittsfl\u00e4che der Skelettmuskulatur auf H\u00f6he des Lendenwirbelk\u00f6rpers L 3 im axialen CT-Schnittbild von 121 Patienten bestimmt, um so den Skelettmuskelindex (SMI [cm2\/m2]) zu erhalten. Es erfolgte au\u00dferdem eine Erfassung weiterer Parameter zur zus\u00e4tzlichen Evaluation deren Assoziation mit der \u00dcberlebenswahrscheinlichkeit.<\/jats:p><jats:p>\n            Ergebnisse Die durchschnittliche \u00dcberlebenszeit der Gruppe der sarkopenen Patienten war mit 14,4 Monaten im Vergleich zu 17,7 Monaten mittlerer \u00dcberlebenszeit bei Patienten ohne Sarkopenie signifikant vermindert (p=0,046). Zus\u00e4tzlich konnten das Alter (p = 0,006), eine nicht erfolgte Resektion des Tumors (p=0,004), Metastasen bei Erstdiagnose (p=0,002) sowie ein erh\u00f6htes CA 19\u20139 (p=0,002) als statistisch signifikante negative Prognosefaktoren identifiziert werden.<\/jats:p><jats:p>\n            Schlussfolgerung Sarkopenie ist ein unabh\u00e4ngiger prognostischer Faktor in Bezug auf die \u00dcberlebenszeit bei Pankreaskarzinompatienten. Dies legt die standardm\u00e4\u00dfige Integration des SMI als Prognoseparameter in den klinischen Alltag nahe, um durch entsprechende pr\u00e4ventive und therapeutische ern\u00e4hrungs- und bewegungsmedizinische Ma\u00dfnahmen m\u00f6glicherweise die Lebensdauer sowie die Lebensqualit\u00e4t von Pankreaskarzinompatienten merklich verbessern zu k\u00f6nnen.<\/jats:p>","DOI":"10.1055\/a-1959-2894","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:17:51Z","timestamp":1670545071000},"page":"1365-1370","source":"Crossref","is-referenced-by-count":2,"title":["Sarkopenie als unabh\u00e4ngiger Prognosefaktor bei Pankreaskarzinom"],"prefix":"10.1055","volume":"61","author":[{"given":"Johanna","family":"Mandl","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Gastroenterologie und interventionelle Endoskopie, Krankenhaus Barmherzige Br\u00fcder Regensburg, Regensburg, 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