{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:56:40Z","timestamp":1780541800127,"version":"3.54.1"},"reference-count":54,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Neurol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sudden unexpected death in epilepsy (SUDEP) is a tragic and unexpected cause of death in patients with a known diagnosis of epilepsy. It occurs in up to 6.3 to 9.3\/1,000 patients with drug-resistant epilepsy. The main three risk factors associated with SUDEP are the presence of generalized tonic\u2013clonic seizures, the presence of a seizure in the past year, and an intellectual disability. There are several mechanisms that can result in SUDEP. The most likely sequence of events appears to be a convulsive seizure, overactivation of the autonomic nervous system, cardiorespiratory dysfunction, and death. While the risk of SUDEP is relatively high in patients with drug-resistant epilepsy, studies indicate that more than 50% of patients and caregivers are unaware of the diagnosis. Counseling about the diagnosis and preventative measures at the time of diagnosis is important. There are numerous interventions that may reduce the risk of SUDEP, including conservative measures such as nocturnal surveillance with a bed partner (where applicable) and automated devices. Optimizing seizure control with antiseizure medications and surgical interventions can result in a reduced risk of SUDEP.<\/jats:p>","DOI":"10.1055\/a-1960-1355","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T23:09:10Z","timestamp":1665616150000},"page":"658-664","source":"Crossref","is-referenced-by-count":4,"title":["Sudden Unexpected Death in Epilepsy: Pathogenesis, Risk Factors, and Prevention"],"prefix":"10.1055","volume":"42","author":[{"given":"Babitha","family":"Haridas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Weill Cornell School of Medicine, New York, New 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Harden","year":"2017","journal-title":"Neurology"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S1474-4422(16)30158-2","article-title":"Sudden unexpected death in epilepsy: epidemiology, mechanisms, and prevention","volume":"15","author":"O Devinsky","year":"2016","journal-title":"Lancet Neurol"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1212\/WNL.51.5.1270","article-title":"Population-based study of the incidence of sudden unexplained death in epilepsy","volume":"51","author":"D M Ficker","year":"1998","journal-title":"Neurology"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1528-1167.2011.03358.x","article-title":"Unifying the definitions of sudden unexpected death in epilepsy","volume":"53","author":"L 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