{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T11:16:06Z","timestamp":1781608566908,"version":"3.54.5"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"S 01","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NIH","award":["NICHD HD089714,NICHD HD100015,NIH-U01 HD087221"],"award-info":[{"award-number":["NICHD HD089714,NICHD HD100015,NIH-U01 HD087221"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003The aim of Placental Assessment in Response to Environmental Pollution Study (PARENTs) was to determine whether imaging of the placenta by novel multiparametric magnetic resonance imaging (MRI) techniques in early pregnancy could help predict adverse pregnancy outcomes (APOs) due to ischemic placental disease (IPD). Additionally, we sought to determine maternal characteristics and environmental risk factors that contribute to IPD and secondary APOs.<\/jats:p><jats:p>\n            Study Design\u2003Potential patients in their first trimester of pregnancy, who agreed to MRI of the placenta and measures of assessment of environmental pollution, were recruited into PARENTs, a prospective population-based cohort study. Participants were seen at three study visits during pregnancy and again at their delivery from 2015 to 2019. We collected data from interviews, chart abstractions, and imaging. Maternal biospecimens (serum, plasma, and urine) at antepartum study visits and delivery specimens (placenta, cord, and maternal blood) were collected, processed, and stored. The primary outcome was a composite of IPD, which included any of the following: placental abruption, hypertensive disease of pregnancy, fetal growth restriction, or a newborn of small for gestational age.<\/jats:p><jats:p>\n            Results\u2003In this pilot cohort, of the 190 patients who completed pregnancy to viable delivery, 50 (26%) developed IPD. Among demographic characteristics, having a history of prior IPD in multiparous women was associated with the development of IPD. In the multiple novel perfusion measurements taken of the in vivo placenta using MRI, decreased high placental blood flow (mL\/100\u2009g\/min) in early pregnancy (between 14 and 16 weeks) was found to be significantly associated with the later development of IPD.<\/jats:p><jats:p>\n            Conclusion\u2003Successful recruitment of the PARENTs prospective cohort demonstrated the feasibility and acceptability of the use of MRI in human pregnancy to study the placenta in vivo and at the same time collect environmental exposure data. Analysis is ongoing and we hope these methods will assist researchers in the design of prospective imaging studies of pregnancy.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1961-2059","type":"journal-article","created":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T00:35:17Z","timestamp":1665794117000},"page":"e853-e862","source":"Crossref","is-referenced-by-count":11,"special_numbering":"S","title":["A Description of the Imaging Innovations for Placental Assessment in Response to Environmental Pollution Study"],"prefix":"10.1055","volume":"41","clinical-trial-number":[{"clinical-trial-number":"nct02786420","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Carla","family":"Janzen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida Y. Y.","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian R.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitaram","family":"Vangala","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Health Services Research, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irish","family":"DelRosario","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Jonathan Fielding School of Public Health at University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Jonathan Fielding School of Public Health at University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Ritz","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Jonathan Fielding School of Public Health at University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Jonathan Fielding School of Public Health at University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Jerrett","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Jonathan Fielding School of Public Health at University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Chanlaw","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arya","family":"Aliabadi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Health Services Research, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Precious Ann","family":"Fortes","sequence":"additional","affiliation":[{"name":"Department of Pathology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy S.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Pathology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisling","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia Del","family":"Vecchio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanthie","family":"Thamotharan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4175-5322","authenticated-orcid":false,"given":"KyungHyun","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Radiology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherin U.","family":"Devaskar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/epirev\/mxt006","article-title":"Pregnancy characteristics and women's future cardiovascular health: an underused opportunity to improve women's health?","volume":"36","author":"J W Rich-Edwards","year":"2014","journal-title":"Epidemiol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ajog.2015.08.037","article-title":"The Human Placenta Project: it's time for real time","volume":"213","author":"A E Guttmacher","year":"2015","journal-title":"Am J Obstet Gynecol"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.placenta.2014.02.012","article-title":"The Human Placenta Project: placental structure, development, and function in real time","volume":"35","author":"A E Guttmacher","year":"2014","journal-title":"Placenta"},{"issue":"08","key":"ref4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.placenta.2014.06.367","article-title":"Invigorating placental research through the \u201cHuman Placenta Project\u201d","volume":"35","author":"Y Sadovsky","year":"2014","journal-title":"Placenta"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1053\/j.semperi.2014.03.001","article-title":"Ischemic placental disease: a unifying concept for preeclampsia, intrauterine growth restriction, and placental abruption","volume":"38","author":"C V Ananth","year":"2014","journal-title":"Semin Perinatol"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.ajog.2006.05.021","article-title":"Maternal-fetal conditions necessitating a medical intervention resulting in preterm birth","volume":"195","author":"C V Ananth","year":"2006","journal-title":"Am J Obstet Gynecol"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1053\/j.semperi.2014.03.006","article-title":"First trimester prediction of ischemic placental disease","volume":"38","author":"A M Vintzileos","year":"2014","journal-title":"Semin Perinatol"},{"issue":"05","key":"ref8","doi-asserted-by":"crossref","first-page":"R26","DOI":"10.1530\/EC-16-0033","article-title":"The potential role of biomarkers in predicting gestational diabetes","volume":"5","author":"H S Brink","year":"2016","journal-title":"Endocr Connect"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/jmri.26944","article-title":"Human placenta blood flow during early gestation with pseudocontinuous arterial spin labeling MRI","volume":"51","author":"D Liu","year":"2020","journal-title":"J Magn Reson Imaging"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"e208243","DOI":"10.1001\/jamanetworkopen.2020.8243","article-title":"Association of air pollution and heat exposure with preterm birth, low birth weight, and stillbirth in the US: a systematic review","volume":"3","author":"B Bekkar","year":"2020","journal-title":"JAMA Netw Open"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"105942","DOI":"10.1016\/j.envint.2020.105942","article-title":"Predicting differential improvements in annual pollutant concentrations and exposures for regulatory policy assessment","volume":"143","author":"J G Su","year":"2020","journal-title":"Environ Int"},{"issue":"06","key":"ref12","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1600-0668.2005.00375.x","article-title":"Ventilation in public housing: implications for indoor nitrogen dioxide concentrations","volume":"15","author":"A Zota","year":"2005","journal-title":"Indoor Air"},{"issue":"03","key":"ref13","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/ijgo.12892","article-title":"Erratum to \u201cThe International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: a pragmatic guide for first-trimester screening and prevention\u201d [Int J Gynecol Obstet 145 Suppl. 1 (2019) 1\u201333]","volume":"146","author":"L C Poon","year":"2019","journal-title":"Int J Gynaecol Obstet"},{"issue":"06","key":"ref14","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1046\/j.0960-7692.2001.00594.x","article-title":"Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler at 11-14 weeks of gestation","volume":"18","author":"A M Martin","year":"2001","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"06","key":"ref15","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1002\/jmri.25893","article-title":"Measuring human placental blood flow with multidelay 3D GRASE pseudocontinuous arterial spin labeling at 3T","volume":"47","author":"X Shao","year":"2018","journal-title":"J Magn Reson Imaging"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"E840","DOI":"10.3390\/diagnostics10100840","article-title":"Characterization of uterine motion in early gestation using MRI-based motion tracking","volume":"10","author":"T Martin","year":"2020","journal-title":"Diagnostics (Basel)"},{"issue":"01","key":"ref17","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/jmri.26203","article-title":"3D [formula: see text] mapping of the placenta during early gestation using free-breathing multiecho stack-of-radial MRI at 3T","volume":"49","author":"T Armstrong","year":"2019","journal-title":"J Magn Reson Imaging"},{"issue":"07","key":"ref18","doi-asserted-by":"crossref","first-page":"698","DOI":"10.5858\/arpa.2015-0225-CC","article-title":"Sampling and definitions of placental lesions: Amsterdam Placental Workshop Group Consensus Statement","volume":"140","author":"T Y Khong","year":"2016","journal-title":"Arch Pathol Lab Med"},{"issue":"05","key":"ref19","first-page":"1122","article-title":"Hypertension in pregnancy. report of the American College of Obstetricians and Gynecologists' Task Force on hypertension in pregnancy","volume":"122","year":"2013","journal-title":"Obstet Gynecol"},{"issue":"01","key":"ref20","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/AOG.0000000000003324","article-title":"Female sexual dysfunction: ACOG Practice Bulletin Clinical Management Guidelines for Obstetrician-Gynecologists, Number 213","volume":"134","author":"American College of Obstetricians and Gynecologists' Committee on Practice Bulletins\u2014Gynecology","year":"2019","journal-title":"Obstet Gynecol"},{"issue":"02","key":"ref21","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1097\/AOG.0000000000002501","article-title":"ACOG Practice Bulletin No. 190: gestational diabetes mellitus","volume":"131","author":"Committee on Practice B-O. ACOG Practice Bulletin No","year":"2018","journal-title":"Obstet Gynecol"},{"issue":"04","key":"ref22","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1097\/AOG.0000000000004350","article-title":"ACOG Practice Bulletin No. 227: fetal growth restriction: correction","volume":"137","author":"ACOG Practice Bulletin No","year":"2021","journal-title":"Obstet Gynecol"},{"issue":"06","key":"ref23","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/uog.2814","article-title":"Sequential changes in uterine artery blood flow pattern between the first and second trimesters of gestation in relation to pregnancy outcome","volume":"28","author":"O G\u00f3mez","year":"2006","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"06","key":"ref24","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1080\/15592294.2020.1816774","article-title":"Cell-free DNA methylation and transcriptomic signature prediction of pregnancies with adverse outcomes","volume":"16","author":"G Del Vecchio","year":"2021","journal-title":"Epigenetics"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1961-2059.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:17:10Z","timestamp":1730812630000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1961-2059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,14]]},"references-count":24,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1961-2059","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,10,14]]},"published":{"date-parts":[[2022,10,14]]}}}