{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:43:25Z","timestamp":1791495805580,"version":"4.3.4"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geburtshilfe Frauenheilkd"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Purpose This meta-analysis was conducted to systematically retrieve relevant randomized controlled trials (RCTs) and evaluate the effects of intrauterine infusion of autologous\n          platelet-rich plasma (PRP) in women with thin endometrium, implantation or pregnancy failure undergoing treatment with assisted reproductive technology (ART).<\/jats:p>\n                  <jats:p>Methods We conducted a systematic review and meta-analysis of the retrieved RCTs. Studies on the intrauterine infusion of PRP in women undergoing treatment with ART that were\n          published in PubMed, the Cochrane library, Web of Science, and Embase from inception until June 2022 were included. The data were extracted and analyzed independently using the fixed-effects\n          or random-effects model according to heterogeneity.<\/jats:p>\n                  <jats:p>Results Seven RCTs involving 861 patients (435 in the intervention group and 426 in the control group) were included. The rates of clinical pregnancy (risk ratio [RR]: 2.51; 95%\n          confidence interval [CI]: 2.0\u20133.13; P\u00a0&lt;\u00a00.00001), chemical pregnancy (RR: 1.96; 95% CI: 1.58\u20132.45; P\u00a0&lt;\u00a00.00001), live births (RR: 7.03; 95% CI: 3.91\u201312.6; P\u00a0&lt;\u00a00.00001), and\n          implantation (RR: 3.27; 95% CI: 1.42\u20137.52; P\u00a0=\u00a00.005) were significantly higher in the women who received PRP infusion than in the control group. No significant differences were noted in the\n          miscarriage rate (RR: 0.98; 95% CI: 0.39\u20132.42; P\u00a0=\u00a00.96) between the two groups.<\/jats:p>\n                  <jats:p>Conclusion In summary, intrauterine infusion of PRP may be an effective therapy for women with thin endometrium and recurrent implantation failure (RIF) undergoing treatment with\n          ART. More population-based RCTs are warranted to verify the efficacy of our evidence.<\/jats:p>","DOI":"10.1055\/a-1963-7459","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:47:16Z","timestamp":1670978836000},"page":"453-462","source":"Crossref","is-referenced-by-count":12,"title":["Effects of Intrauterine Infusion of Autologous Platelet-Rich Plasma in Women Undergoing Treatment with Assisted Reproductive Technology: a Meta-Analysis of Randomized Controlled\n          Trials"],"prefix":"10.1055","volume":"83","author":[{"given":"Shifu","family":"Hu","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhishan","family":"Jin","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Tang","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1177\/1933719116657193","article-title":"Obstetrics and Gynecology Residency and Fertility Needs","volume":"24","author":"L Aghajanova","year":"2017","journal-title":"Reprod Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1093\/humupd\/dmy044","article-title":"Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis","volume":"25","author":"L 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