{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:36:07Z","timestamp":1740137767226,"version":"3.37.3"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"Health System Research Institute, the Ministry of Public Health, Thailand"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>\n            Background\u2003External validation is essential before implementing a predictive model in clinical practice. This analysis validated the performance of the ACUITY\/HORIZON risk score in the most contemporary Thai PCI registry.<\/jats:p><jats:p>\n            Methods\u2003The ACUITY\/HORIZON model was applied and validated externally in 12,268 ACS (acute coronary syndrome) patients. For revision and updating models, the regression coefficientd of all predictors were re-estimated and then additional predictors were stepwise selected from multivariate analysis.<\/jats:p><jats:p>\n            Results\u2003In-hospital bleeding defined by the BARC (Bleeding Academic Research Consortium) criteria was 1.3% (161 patients) and 2.3% (285 patients) by the ACUITY criteria. The calibration of both scales demonstrated overestimation of the original model with C-statistic values of 0.704 for ACUITY major bleeding and 0.793 for BARC 3 or 5 bleeding. For ACUITY major bleeding, the discriminatory power of the update model improved substantially when congestive heart failure (CHF), prior vascular disease as well as body mass index were considered. The update model demonstrated good calibration and C-statistic of 0.747 and 0.745 with no white blood cell (WBC) count. For BARC 3 or 5 bleeding, good calibration and discriminatory capacity could be observed when CHF and prior vascular disease were added in the update models, with an excellent C-statistic of 0.838, and a lower C-statistic value of 0.835 was obtained in the absence of WBC count.<\/jats:p><jats:p>\n            Conclusion\u2003The ACUITY\/HORIZON score was successfully validated in contemporary predictive and risk-adjustment models for PCI-related bleeding. The update models had good operating characteristics in patients from a real-world ACS population irrespective of bleeding definitions.<\/jats:p>","DOI":"10.1055\/a-1964-8247","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T22:48:19Z","timestamp":1666306099000},"page":"255-266","source":"Crossref","is-referenced-by-count":1,"title":["External Validation of the ACUITY\/HORIZON Bleeding Risk Score among Acute Coronary Syndrome Patients in Thai PCI Registry"],"prefix":"10.1055","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6431-6192","authenticated-orcid":false,"given":"Worawut","family":"Roongsangmanoon","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Faculty of Medicine, Srinakharinwirot University, Ongkharak Campus, Nakhon Nayok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ply","family":"Chichareon","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkla, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teeranan","family":"Angkananard","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Faculty of Medicine, Srinakharinwirot University, Ongkharak Campus, Nakhon Nayok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pannipa","family":"Suwannasom","sequence":"additional","affiliation":[{"name":"Northern Region Heart Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mann","family":"Chandavimol","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thosaphol","family":"Limpijankit","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suphot","family":"Srimahachota","sequence":"additional","affiliation":[{"name":"Cardiac Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siriporn","family":"Athisakul","sequence":"additional","affiliation":[{"name":"Cardiac Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pisit","family":"Hutayanon","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Medicine, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songsak","family":"Kiatchoosakun","sequence":"additional","affiliation":[{"name":"Cardiology unit, Department of Medicine, Faculty of Medicine, Khonkaen University, Khon Kaen, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praprut","family":"Thanakitcharu","sequence":"additional","affiliation":[{"name":"Cardiac center, Sunpasitthiprasong Hospital Ubon Ratchathani, Ubon Ratchathani, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montri","family":"Charoenpanichsunti","sequence":"additional","affiliation":[{"name":"Cardiac Center, Phyathai Sriracha General Hospital, Chonburi, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prajongjit","family":"Chamsaard","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Bhumibol Adulyadej Hospital, Bangkok, 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