{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T06:14:58Z","timestamp":1683267298841},"reference-count":41,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg G Grosstiere Nutztiere"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Gegenstand und Ziel Die Vorstellungsgr\u00fcnde, klinische Symptomatik, Diagnostik, Therapie und Ergebnis der Therapie von 12\u2005Pferden mit klinisch apparenter West-Nil-Virus (WNV)-Infektion werden beschrieben.<\/jats:p><jats:p>\n          Material und Methoden Fallserie<\/jats:p><jats:p>\n          Ergebnisse Die adulten Pferde (Alter 6\u201318\u2005Jahre, 7\u2005Stuten, 5\u2005Wallache) aus Sachsen oder Sachsen-Anhalt wurden zwischen September 2018 und September 2020 mit unterschiedlichen Vorberichten vorgestellt. Alle Pferde wurden im August oder September vorgestellt und keines der Pferde war gegen das WNV geimpft. Fieber war das h\u00e4ufigste Allgemeinsymptom und trat bei 8\/12\u2005Pferden auf. An neurologischen Symptomen traten Muskelfaszikulationen (11\/12\u2005Pferde), Ataxie (8\/12\u2005Pferde) sowie Hyper\u00e4sthesie und Kopfschiefhaltung (je 6\/12\u2005Pferde) am h\u00e4ufigsten auf. Bei allen Pferden wurde die Infektion mittels Nachweises von IgM sowie neutralisierenden Antik\u00f6rpern gegen das WNV diagnostiziert, zwei euthanasierte Pferde waren zudem PCR-positiv. Die symptomatische Therapie beinhaltete vor allem nicht-steroidale Antiphlogistika oder Dexamethason sowie Infusionstherapie. Die Dauer des Klinikaufenthaltes betrug im Durchschnitt 7,5\u2005Tage. Sieben Pferde erholten sich laut Besitzerangaben vollst\u00e4ndig, f\u00fcr 2\u2005Pferde war keine Information erh\u00e4ltlich.<\/jats:p><jats:p>\n          Schlussfolgerungen und klinische Relevanz Die WNV-Enzephalomyelitis muss in Mitteldeutschland seit 2018 als Differentialdiagnose von im Sommer und Sp\u00e4tsommer auftretenden akuten neurologischen Erkrankungen ungeimpfter Pferdes in Betracht gezogen werden. Die beschriebenen Symptome sowie das Ergebnis der Therapie sind weitgehend deckungsgleich mit Berichten aus Nordamerika und anderen europ\u00e4ischen L\u00e4ndern.<\/jats:p>","DOI":"10.1055\/a-1965-0307","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T23:30:13Z","timestamp":1671060613000},"page":"362-376","source":"Crossref","is-referenced-by-count":1,"title":["West-Nil-Virus-Infektion bei 12 Pferden in Mitteldeutschland"],"prefix":"10.1055","volume":"50","author":[{"given":"Katharina Luise","family":"Lohmann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Pferde, Veterin\u00e4rmedizinische Fakult\u00e4t, Universit\u00e4t Leipzig"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sieg","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie, Veterin\u00e4rmedizinische Fakult\u00e4t, Universit\u00e4t Leipzig"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Landmann","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Veterin\u00e4r-Pathologie, Veterin\u00e4rmedizinische Fakult\u00e4t, Universit\u00e4t Leipzig"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Ganzenberg","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Pferde, Veterin\u00e4rmedizinische Fakult\u00e4t, Universit\u00e4t Leipzig"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinna","family":"Arnold","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Pferde, Veterin\u00e4rmedizinische Fakult\u00e4t, Universit\u00e4t Leipzig"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Vahlenkamp","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie, Veterin\u00e4rmedizinische Fakult\u00e4t, Universit\u00e4t Leipzig"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiner Georg","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Veterin\u00e4r-Pathologie, Veterin\u00e4rmedizinische Fakult\u00e4t, Universit\u00e4t Leipzig"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0065-3527(03)59001-7","article-title":"Taxonomy of the virus family Flaviviridae","volume":"59","author":"C H Calisher","year":"2003","journal-title":"Adv Virus Res"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"380","DOI":"10.3201\/eid0804.010239","article-title":"Experimental infection of horses with West Nile virus","volume":"8","author":"M L Bunning","year":"2002","journal-title":"Emerg Infect 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Nutztiere"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1965-0307.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T23:30:18Z","timestamp":1671060618000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1965-0307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":41,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2022,12,14]]},"published-print":{"date-parts":[[2022,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1965-0307","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1434-1220","2567-5834"],"issn-type":[{"value":"1434-1220","type":"print"},{"value":"2567-5834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]}}}