{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:47Z","timestamp":1740126827555,"version":"3.37.3"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gesundheitswesen"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund und Ziel der Studie Sich st\u00e4ndig ver\u00e4ndernde\n                    Virusvarianten des neuartigen Coronavirus SARS-CoV-2 stellen das\n                    Gesundheitswesen vor gro\u00dfe Herausforderungen. In der vorliegenden Arbeit\n                    soll die Analyse der gr\u00f6\u00dferen Ausbruchsgeschehen der Varianten\n                    Alpha und Beta in K\u00f6ln ein effektives und schnelles Reagieren auf neue\n                    Virusvarianten und zuk\u00fcnftige Pandemien sowie das Ableiten\n                    zielf\u00fchrender Ma\u00dfnahmen zur Pandemiebek\u00e4mpfung\n                    erm\u00f6glichen.<\/jats:p><jats:p>\n          Methodik Im Beobachtungszeitraum vom 22. Januar bis 23. Februar 2021\n                    wurden alle dem Gesundheitsamt K\u00f6ln gemeldeten SARS-CoV-2 positiv\n                    getesteten Personen sowie deren Kontaktpersonen individuellen telefonischen\n                    Befragungen von Mitarbeitenden des Gesundheitsamtes unterzogen. Diese Daten\n                    bildeten zum einen die Grundlage der epidemiologischen und deskriptiven\n                    Gegen\u00fcberstellung der Alpha- und der Beta-Variante im Vergleich zum\n                    zuvor vorherrschenden Wildtyp. Zum anderen waren sie auch Basis der grafischen\n                    Aufarbeitung von Clustern, die durch die beiden Virusvarianten gebildet wurden,\n                    in Form sogenannter Timelines. F\u00fcr die vorliegende Arbeit wurden alle\n                    Cluster mit \u226510 Individuen f\u00fcr den betrachteten Zeitraum\n                    ber\u00fccksichtigt.<\/jats:p><jats:p>\n          Ergebnisse Von den im Beobachtungszeitraum in K\u00f6ln 3780 positiv\n                    auf SARS-CoV-2 getesteten Personen waren 818 F\u00e4lle auf die\n                    Virusvarianten Alpha und Beta zur\u00fcckzuf\u00fchren. Dabei breitete\n                    sich die Alpha- gegen\u00fcber der Beta-Variante trotz strenger\n                    nicht-pharmazeutischer Eingriffe schnell aus. Im Rahmen der Clusteranalyse\n                    wurden f\u00fcnf gr\u00f6\u00dfere Ausbruchsgeschehen im\n                    Beobachtungszeitraum in K\u00f6ln ermittelt. Zu den Alpha-Varianten-Clustern\n                    geh\u00f6rten zwei Kindertageseinrichtungen und ein Kloster, wohingegen zu\n                    den Beta-Varianten-Clustern eine Gemeinschaftsunterkunft f\u00fcr\n                    Gefl\u00fcchtete und ein Alten- und Pflegeheim z\u00e4hlten. Mithilfe der\n                    Clusteranalyse wurde die Kernrolle des h\u00e4uslichen Settings f\u00fcr\n                    die Ausbreitung der untersuchten Virusvarianten aufgezeigt. Zudem wurde ein\n                    hoher Anteil an F\u00e4llen unbekannten Infektionsortes\/-kontaktes\n                    f\u00fcr den Wildtyp und die Alpha-Variante festgestellt.<\/jats:p><jats:p>\n          Schlussfolgerung Clusteranalysen stellen ein \u00e4u\u00dferst\n                    n\u00fctzliches Instrument in der Ermittlung von\n                    Infektionsorten\/-kontakten und \u00dcbertragungswegen sowie der\n                    Eruierung bestehender Schutzma\u00dfnahmen und Hygienekonzepte dar. Da\n                    entsprechende Cluster als ung\u00fcnstigstes Ausbreitungsszenario zu\n                    betrachten sind, liefern sie wichtige Erkenntnisse f\u00fcr Modifizierungen\n                    im weiteren Handeln sowohl f\u00fcr diese als auch f\u00fcr\n                    zuk\u00fcnftige Pandemien.<\/jats:p>","DOI":"10.1055\/a-1967-9855","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:02:22Z","timestamp":1670457742000},"page":"123-132","source":"Crossref","is-referenced-by-count":0,"title":["Ausbreitungsdynamik der Alpha- und Beta-Virusvarianten von\n                    SARS-CoV-2 zum Beginn ihres Auftretens in der Stadt K\u00f6ln im\n                    Januar und Februar 2021"],"prefix":"10.1055","volume":"85","author":[{"given":"Anastasia","family":"Weirich","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Arbeits-, Sozial- und Umweltmedizin, Uniklinik\n                    RWTH Aachen, Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5478-171X","authenticated-orcid":false,"given":"Gerhard A.","family":"Wiesmueller","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Arbeits-, Sozial- und Umweltmedizin, Uniklinik\n                    RWTH Aachen, Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Hurra\u00df","sequence":"additional","affiliation":[{"name":"Infektions- und Umwelthygiene, Gesundheitsamt der Stadt K\u00f6ln,\n                    K\u00f6ln, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelene","family":"Kossow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"eabg3055","DOI":"10.1126\/science.abg3055","article-title":"Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in\n                    England","volume":"372","author":"N G Davies","year":"2021","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41586-021-03470-x","article-title":"Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England","volume":"593","author":"E Volz","year":"2021","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1016\/j.cell.2021.03.052","article-title":"Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States","volume":"184","author":"N L Washington","year":"2021","journal-title":"Cell"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1016\/S1473-3099(21)00290-5","article-title":"Risk of hospitalisation associated with infection with SARS-CoV-2 lineage\n                    B.1.1.7 in Denmark: an observational cohort study","volume":"21","author":"P Bager","year":"2021","journal-title":"Lancet Infect Dis"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e0258513","DOI":"10.1371\/journal.pone.0258513","article-title":"Increased risk of hospitalisation and intensive care admission associated with\n                    reported cases of SARS-CoV-2 variants B.1.1.7 and B.1.351 in Norway, December\n                    2020-May 2021","volume":"16","author":"L Veneti","year":"2021","journal-title":"PLOS ONE"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-021-03426-1","article-title":"CMMID COVID-19 Working Group et al. 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