{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T14:06:33Z","timestamp":1781359593053,"version":"3.54.1"},"reference-count":69,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacopsychiatry"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Drug repurposing is a strategy to identify new indications for already approved\n                    drugs. A recent successful example in psychiatry is ketamine, an anesthetic drug\n                    developed in the 1960s, now approved and clinically used as a fast-acting\n                    antidepressant. Here, we describe the potential of dexmedetomidine as a\n                    psychopharmacological repurposing candidate. This\n                    \u03b12-adrenoceptor agonist is approved in the US and Europe for\n                    procedural sedation in intensive care. It has shown fast-acting inhibitory\n                    effects on perioperative stress-related pathologies, including psychomotor\n                    agitation, hyperalgesia, and neuroinflammatory overdrive, proving potentially\n                    useful in clinical psychiatry. We offer an overview of the pharmacological\n                    profile and effects of dexmedetomidine with potential utility for the treatment\n                    of neuropsychiatric symptoms. Dexmedetomidine exerts fast-acting and robust\n                    sedation, anxiolytic, analgesic, sleep-modulating, and anti-inflammatory\n                    effects. Moreover, the drug prevents postoperative agitation and delirium,\n                    possibly via neuroprotective mechanisms. While evidence in animals and humans\n                    supports these properties, larger controlled trials in clinical samples are\n                    generally scarce, and systematic studies with psychiatric patients do not exist.\n                    In conclusion, dexmedetomidine is a promising candidate for an experimental\n                    treatment targeting stress-related pathologies common in neuropsychiatric\n                    disorders such as depression, anxiety disorders, and posttraumatic stress\n                    disorder. First small proof-of-concept studies and then larger controlled\n                    clinical trials are warranted in psychiatric populations to test the feasibility\n                    and efficacy of dexmedetomidine in these conditions.<\/jats:p>","DOI":"10.1055\/a-1970-3453","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:23:41Z","timestamp":1668644621000},"page":"44-50","source":"Crossref","is-referenced-by-count":27,"title":["Dexmedetomidine in Psychiatry: Repurposing of its Fast-Acting\n                    Anxiolytic, Analgesic and Sleep Modulating Properties"],"prefix":"10.1055","volume":"56","author":[{"given":"Oliver G.","family":"Bosch","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric\n                    University Hospital Zurich, University of Zurich, Lenggstrasse, Zurich,\n                    Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario A.","family":"Dornbierer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric\n                    University Hospital Zurich, University of Zurich, Lenggstrasse, Zurich,\n                    Switzerland"},{"name":"Institute of Pharmacology and Toxicology, University of Zurich,\n                    Winterthurerstrasse, Z\u00fcrich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bavato","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric\n                    University Hospital Zurich, University of Zurich, Lenggstrasse, Zurich,\n                    Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris B.","family":"Quednow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric\n                    University Hospital Zurich, University of Zurich, Lenggstrasse, Zurich,\n                    Switzerland"},{"name":"Neuroscience Center Zurich, University of Zurich and Swiss Federal\n                    Institute of Technology Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Landolt","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University of Zurich,\n                    Winterthurerstrasse, Z\u00fcrich"},{"name":"Neuroscience Center Zurich, University of Zurich and Swiss Federal\n                    Institute of Technology Zurich, Switzerland"},{"name":"Sleep & Health Zurich, University Center of Competence,\n                    University of Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich","family":"Seifritz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric\n                    University Hospital Zurich, University of Zurich, Lenggstrasse, Zurich,\n                    Switzerland"},{"name":"Neuroscience Center Zurich, University of Zurich and Swiss Federal\n                    Institute of Technology Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/news.2011.367.20","article-title":"Psychopharmacology in crisis","author":"D Cressey","year":"2011","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuron.2019.02.005","article-title":"Ketamine: A paradigm shift for depression research and treatment","volume":"101","author":"J H Krystal","year":"2019","journal-title":"Neuron"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3928\/02793695-20130709-01","article-title":"Efficacy of quetiapine off-label uses: Data synthesis","volume":"51","author":"AC Carney","year":"2013","journal-title":"J Psychosoc Nurs Ment Health Serv"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/bja\/aex086","article-title":"Dexmedetomidine pharmacodynamics in healthy volunteers: 2. 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alleviates anxiety-like behaviors and cognitive impairments in a\n                    rat model of post-traumatic stress disorder","volume":"54","author":"M H Ji","year":"2014","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbr.2017.04.048","article-title":"Effects of ketamine, dexmedetomidine and propofol anesthesia on emotional memory\n                    consolidation in rats: Consequences for the development of post-traumatic stress\n                    disorder","volume":"329","author":"M Morena","year":"2017","journal-title":"Behav Brain Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/pan.13010","article-title":"Comparison of oral midazolam with intranasal dexmedetomidine premedication for\n                    children undergoing CT imaging: A randomized, double-blind, and controlled\n                    study","volume":"27","author":"B 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