{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:13:09Z","timestamp":1790781189907,"version":"4.1.0"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2002Probiotics are often viewed as an immunity enhancing\n                    agent. The objective of this study was to investigate whether oral\n                    administration of Escherichia coli Nissle 1917 reduces the number of infections,\n                    their duration, and severity in the first 24 months after parturition in healthy\n                        neonates.<\/jats:p><jats:p>\n          Subjects and methods\u2002This prospective, confirmatory,\n                    randomised, double-blind, placebo-controlled study enrolled 567 healthy neonates\n                    from four German and two Polish sites. Neonates received 10e8 viable E. coli\n                    Nissle (n=283) or placebo (n=284) daily in the first week and\n                    every second day in week 2 and 3. After 6 and 12 months, the subjects received\n                    additional instillations on ten subsequent days. The overall efficacy was\n                    assessed by the number of infections per observation\n                    period.<\/jats:p><jats:p>\n          Results\u2002Incidence rates of infection, infection duration\n                    and severity showed no statistically significant difference between groups after\n                    24 months. Post-hoc analyses, however, revealed a short-term benefit of E. coli\n                    Nissle four weeks after treatment start which became less pronounced after eight\n                    weeks. E. coli Nissle was safe and well tolerated.<\/jats:p><jats:p>\n          Conclusions\u2002A\n                    long-term effect after colonising the healthy neonate\u00b4s gut with E. coli\n                    Nissle to protect against infections could not be shown. Additional studies are\n                    needed to confirm a transitory, yet clinically significant role of probiotics in\n                    the first four weeks after parturition.<\/jats:p>","DOI":"10.1055\/a-1970-4340","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T02:24:15Z","timestamp":1669775055000},"page":"213-220","source":"Crossref","is-referenced-by-count":6,"title":["Potential Benefit of Probiotic E. Coli Nissle in Term Neonates"],"prefix":"10.1055","volume":"235","author":[{"given":"Dirk","family":"Olbertz","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Klinikum S\u00fcdstadt Rostock, Rostock,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Proquitt\u00e9","sequence":"additional","affiliation":[{"name":"Section of Neonatology and Neonatal Intensive Care, Department of\n                    Pediatrics, Jena University Hospital, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig","family":"Patzer","sequence":"additional","affiliation":[{"name":"Pediatrics, Children\u2019s Hospital St. Elisabeth and St. Barbara,\n                    Halle\/Saale, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5752-4724","authenticated-orcid":false,"given":"Thomas","family":"Erler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Klinikum Westbrandenburg, Potsdam,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexsandra","family":"Mikolajczak","sequence":"additional","affiliation":[{"name":"Department of Neonatology, University Clinical Centre of Warsaw Medical\n                    University, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Sadowska-Krawczenko","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Nicolaus Copernicus University in\n                    Toru\u0144 Ludwik Rydygier Collegium Medicum in Bydgoszcz, Bydgoszcz,\n                    Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Wolff","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Ardeypharm GmbH, Herdecke,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Radke","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital Rostock, Rostock,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"G411","DOI":"10.1152\/ajpgi.00399.2020","article-title":"Dynamics of the preterm gut microbiome in health and disease","volume":"320","author":"A Cuna","year":"2021","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/ni0710-558","article-title":"The 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