{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:26:14Z","timestamp":1792268774393,"version":"4.4.0"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003The endoscopic endonasal approach (EEA) is a commonly used technique for resection of sellar, suprasellar, and anterior fossa masses. One of the most troublesome complications of this technique is cerebrospinal fluid (CSF) leak. In this study, we evaluate the risk factors and consequences of CSF leak on surgical outcomes.<\/jats:p><jats:p>\n          Methods\u2003The current study is a retrospective single-institution cohort study evaluating patients who underwent EEA for sellar and\/or suprasellar masses from July 2017 to March of 2020. Risk factors for intraoperative and postoperative CSF leak were evaluated, including sellar defect size, tumor volume and pathology, age, body mass index, prior endoscopic endonasal surgery, lumbar drain placement, nasoseptal and mucosal graft use, year of surgery, and cavernous sinus invasion. Postoperative infection, perioperative antibiotic use, and length of stay were also evaluated.<\/jats:p><jats:p>\n          Results\u2003Our study included 175 patients. Sellar defect size (p\u2009=\u20090.015) and intraoperative CSF leak (p\u2009&lt;\u20090.001) were significantly associated with an increased risk of postoperative CSF leak. Patients with nasoseptal flaps were more likely to have a postoperative CSF leak than those with free mucosal grafts (p\u2009=\u20090.025). Intraoperative CSF leak, Cushing's disease, and lumbar drain placement were associated with an increased length of stay.<\/jats:p><jats:p>\n          Conclusion\u2003Sellar defect size, intraoperative CSF leak, and nasoseptal flap use were associated with an increased risk of postoperative CSF leak. Intraoperative CSF leak, Cushing's disease, and lumbar drain placement are all associated with an increased length of stay.<\/jats:p>","DOI":"10.1055\/a-1970-7970","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:07:03Z","timestamp":1667434023000},"page":"009-014","source":"Crossref","is-referenced-by-count":6,"title":["Predictors and Complications of Cerebrospinal Fluid Leak after Endoscopic Endonasal Surgery: A Single Institution Retrospective Review"],"prefix":"10.1055","volume":"85","author":[{"given":"Brandon","family":"Laing","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Best","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Aaronson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Zwagerman","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s11102-017-0839-1","article-title":"Preoperatibe risk factors 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Ahmed","year":"2017","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref14","first-page":"1","article-title":"Does lumbar drainage reduce postoperative cerebrospinal fluid leak after endoscopic endonasal skull base surgery? A prospect randomized controlled trial","author":"N Zwagerman","year":"2018","journal-title":"J Neurosurg"},{"issue":"06","key":"ref15","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.3171\/2010.10.JNS09406","article-title":"Endoscopic endonasal skull base surgery: analysis of complications in the authors' initial 800 patients","volume":"114","author":"A B Kassam","year":"2011","journal-title":"J Neurosurg"},{"issue":"05","key":"ref16","first-page":"1337","article-title":"Evaluation of early postoperative day 1 discharge after endoscopic endonasal pituitary adenoma resection","volume":"135","author":"S Yu","year":"2021","journal-title":"J Neurosurg"},{"issue":"01","key":"ref17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/0003489415595424","article-title":"Inpatient complications after transsphenoidal surgery in Cushing's versus non-Cushing's disease patients","volume":"125","author":"P Svider","year":"2016","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"06","key":"ref18","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/alr.22540","article-title":"Predicting prolonged length of stay after endoscopic transsphenoidal surgery for pituitary adenoma","volume":"10","author":"S Vimawala","year":"2020","journal-title":"Int Forum Allergy Rhinol"}],"container-title":["Journal of Neurological Surgery Part B: Skull Base"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1970-7970.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:03:05Z","timestamp":1730811785000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1970-7970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,2]]},"references-count":18,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2024,1,24]]},"published-print":{"date-parts":[[2024,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1970-7970","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6331","2193-634X"],"issn-type":[{"value":"2193-6331","type":"print"},{"value":"2193-634X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,11,2]]},"published":{"date-parts":[[2022,11,2]]}}}