{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:54:41Z","timestamp":1778810081046,"version":"3.51.4"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"DOI":"10.13039\/501100007192","name":"Rijksinstituut voor Volksgezondheid en Milieu","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007192","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>\n            Background\u2002Advanced serrated polyps (ASPs) have a comparable risk to advanced adenomas for progression to colorectal cancer (CRC). The yield of most CRC screening programs, however, is based on advanced adenomas and CRC only. We assessed the ASP detection rate, and positive predictive value (PPV) including ASPs in a fecal immunochemical test (FIT)-based screening program.<\/jats:p><jats:p>\n            Methods\u2002We analyzed the findings of follow-up colonoscopies of FIT-positive screenees in the Dutch CRC screening program from 2014 until 2020. Data were retrieved from the national screening and pathology database. An ASP was defined as any serrated polyp of \u2265\u200a10\u200amm, sessile serrated lesion with dysplasia, or traditional serrated adenoma. The ASP detection rate was defined as the proportion of colonoscopies with \u2265\u200a1 ASP. PPV was originally defined as the proportion of individuals with a CRC or advanced adenoma. The updated PPV definition included CRCs, advanced adenomas, and\/or ASPs.<\/jats:p><jats:p>\n            Results\u2002322\u200a882 colonoscopies were included in the analyses. The overall detection rate of ASPs was 5.9\u200a%. ASPs were detected more often in women than men (6.3\u200a% vs. 5.6\u200a%; P\u200a&lt;\u200a0.001). ASP detection rates in individuals aged 55\u201359, 60\u201364, 65\u201369, and 70\u200a+\u200awere 5.2\u200a%, 6.1\u200a%, 6.1\u200a%, and 5.9\u200a%, respectively (P\u200a&lt;\u200a0.001). The PPV for CRCs and advanced adenomas was 41.1\u200a% and increased to 43.8\u200a% when including ASPs. The PPV increase was larger in women than in men (3.2 vs. 2.4 percentage points).<\/jats:p><jats:p>\n            Conclusions\u20025.9\u200a% of FIT-positive screenees had ASPs, but half of these were detected in combination with a CRC or advanced adenoma. Therefore, including ASPs results in a small increase in the yield of FIT-based screening.<\/jats:p>","DOI":"10.1055\/a-1971-3488","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:01:35Z","timestamp":1667433695000},"page":"526-534","source":"Crossref","is-referenced-by-count":11,"title":["Advanced serrated polyps as a target of screening: detection rate and positive predictive value within a fecal immunochemical test-based colorectal cancer screening population"],"prefix":"10.1055","volume":"55","author":[{"given":"David E. F. W. M.","family":"van Toledo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands"},{"name":"Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands"},{"name":"Cancer Center Amsterdam, Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie C. H.","family":"Breekveldt","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands"},{"name":"Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joep E. G.","family":"IJspeert","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands"},{"name":"Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands"},{"name":"Cancer Center Amsterdam, Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anneke J.","family":"van Vuuren","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Folkert J.","family":"van Kemenade","sequence":"additional","affiliation":[{"name":"Department of Pathology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Ramakers","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris D.","family":"Nagtegaal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique E.","family":"van Leerdam","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Department of Gastroenterology, Netherlands Cancer Institute-Antoni Van Leeuwenhoek, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9103-9757","authenticated-orcid":false,"given":"Manon C. W.","family":"Spaander","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Lansdorp-Vogelaar","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Toes-Zoutendijk","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4363-0745","authenticated-orcid":false,"given":"Evelien","family":"Dekker","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, University of Amsterdam, 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Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1053\/j.gastro.2010.06.074","article-title":"Proximal and large hyperplastic and nondysplastic serrated polyps detected by colonoscopy are associated with neoplasia","volume":"139","author":"M A Schreiner","year":"2010","journal-title":"Gastroenterology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1097\/PAS.0b013e3181e4f256","article-title":"Longitudinal outcome study of sessile serrated adenomas of the colorectum: an increased risk for subsequent right-sided colorectal carcinoma","volume":"34","author":"F I Lu","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/apm.12355","article-title":"Hyperplastic polyps of the colon and rectum - reclassification, BRAF and KRAS status in index polyps and subsequent colorectal carcinoma","volume":"123","author":"H G Janjua","year":"2015","journal-title":"APMIS"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1053\/j.gastro.2015.11.046","article-title":"Increased risk of colorectal cancer development among patients with serrated polyps","volume":"150","author":"R Erichsen","year":"2016","journal-title":"Gastroenterology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1136\/gutjnl-2014-307793","article-title":"Long-term risk of colorectal cancer in individuals with serrated polyps","volume":"64","author":"\u00d8 Holme","year":"2015","journal-title":"Gut"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1053\/j.gastro.2019.06.039","article-title":"Long-term risk of colorectal cancer after removal of conventional adenomas and serrated polyps","volume":"158","author":"X He","year":"2020","journal-title":"Gastroenterology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1056\/NEJMoa1311194","article-title":"Multitarget stool DNA testing for colorectal-cancer screening","volume":"370","author":"T F Imperiale","year":"2014","journal-title":"NEJM"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.cgh.2016.07.029","article-title":"Fecal immunochemical test detects sessile serrated adenomas and polyps with a low level of sensitivity","volume":"15","author":"L C Chang","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.mayocp.2015.10.008","article-title":"Stool DNA testing for screening detection of colorectal neoplasia in Alaska Native People","volume":"91","author":"D G Redwood","year":"2016","journal-title":"Mayo Clin 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IJspeert","year":"2017","journal-title":"Histopathology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.cgh.2016.03.044","article-title":"High-quality bowel preparation is required for detection of sessile serrated polyps","volume":"14","author":"B T Clark","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1136\/gutjnl-2015-310587","article-title":"Detection rate and predictive factors of sessile serrated polyps in an organised colorectal cancer screening programme with immunochemical faecal occult blood test: the EQuIPE study (Evaluating Quality Indicators of the Performance of Endoscopy)","volume":"66","author":"M Zorzi","year":"2017","journal-title":"Gut"},{"key":"ref17","first-page":"19","article-title":"Pathology databanking and biobanking in The Netherlands, a central role for PALGA, the nationwide histopathology and cytopathology data network and archive","volume":"29","author":"M Casparie","year":"2007","journal-title":"Cell Oncol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1053\/j.gastro.2012.06.001","article-title":"Guidelines for colonoscopy surveillance after screening and polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer","volume":"143","author":"D A Lieberman","year":"2012","journal-title":"Gastroenterology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1055\/a-1185-3109","article-title":"Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline \u2013 Update 2020","volume":"52","author":"C Hassan","year":"2020","journal-title":"Endoscopy"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cgh.2014.07.044","article-title":"Findings in the distal colorectum are not associated with proximal advanced serrated lesions","volume":"13","author":"C J Kahi","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1136\/gutjnl-2015-310784","article-title":"Detection rate of serrated polyps and serrated polyposis syndrome in colorectal cancer screening cohorts: a European overview","volume":"66","author":"J EG IJspeert","year":"2017","journal-title":"Gut"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1038\/ajg.2010.315","article-title":"Variation in the detection of serrated polyps in an average risk colorectal cancer screening cohort","volume":"105","author":"J T Hetzel","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.gie.2014.04.064","article-title":"Sessile serrated polyp prevalence determined by a colonoscopist with a high lesion detection rate and an experienced pathologist","volume":"81","author":"K Abdeljawad","year":"2015","journal-title":"Gastrointest Endosc"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.cgh.2017.07.011","article-title":"Cost-effectiveness of high-performance biomarker tests vs. fecal immunochemical test for noninvasive colorectal cancer screening","volume":"16","author":"I Lansdorp-Vogelaar","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/codi.13336","article-title":"Hypermethylated DNA as a biomarker for colorectal cancer: a systematic review","volume":"18","author":"S L Rasmussen","year":"2016","journal-title":"Colorectal Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1053\/j.gastro.2014.09.038","article-title":"Association between molecular subtypes of colorectal cancer and patient survival","volume":"148","author":"A I Phipps","year":"2015","journal-title":"Gastroenterology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1053\/j.gastro.2014.09.041","article-title":"Molecular markers identify subtypes of stage III colon cancer associated with patient outcomes","volume":"148","author":"F A Sinicrope","year":"2015","journal-title":"Gastroenterology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1136\/gutjnl-2015-310456","article-title":"Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma","volume":"66","author":"M Bettington","year":"2017","journal-title":"Gut"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/path.5881","article-title":"The earliest events in BRAF-mutant colorectal cancer: exome sequencing of sessile serrated lesions with a tiny focus dysplasia or cancer reveals recurring mutations in two distinct progression pathways","volume":"257","author":"A GC Bleijenberg","year":"2022","journal-title":"J Pathol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1056\/NEJMoa054967","article-title":"Colonoscopy in colorectal-cancer screening for detection of advanced neoplasia","volume":"355","author":"J Regula","year":"2006","journal-title":"NEJM"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1038\/ajg.2010.301","article-title":"Sex differences in performance of fecal occult blood testing","volume":"105","author":"H Brenner","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.cgh.2015.02.023","article-title":"Gender differences in fecal immunochemical test performance for early detection of colorectal neoplasia","volume":"13","author":"A Kapidzic","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S2468-1253(22)00090-5","article-title":"Serrated polyp detection and risk of interval post-colonoscopy colorectal cancer: a population-based study","volume":"7","author":"D EFWM van Toledo","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1007\/s10620-019-05569-8","article-title":"Low sensitivity of fecal immunochemical tests and blood-based markers of DNA hypermethylation for detection of sessile serrated adenomas\/polyps","volume":"64","author":"C Cock","year":"2019","journal-title":"Dig Dis 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