{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:11:07Z","timestamp":1787235067732,"version":"build-2736575974"},"reference-count":46,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This article aims to explore associated immune indicators of autoimmune thyroid disease (AITD) through a meta-analysis of published case-control studies on newly diagnosed AITD patients, intending to provide some suggestions for research on the mechanisms of AITD. Six electronic databases were searched for case-control studies on newly diagnosed AITD patients from inception to August 15, 2022. A random-effects model was used to calculate the standardized mean difference (SMD), odds ratio (OR), and 95% confidence interval (95% CI). A total of 26 articles were included in this meta-analysis. Patients with newly diagnosed AITD had higher levels of helper T cell 17 (Th17) (Hashimoto\u2019s disease (HT): SMD=2.35, 95% CI: 1.98, 2.72; Graves\u2019 disease (GD): SMD=1.61, 95% CI: 1.23, 1.98), lower levels of regulatory T cell (Treg) (HT: SMD=\u20132.04, 95% CI: \u20132.67, \u20131.42; GD: SMD=\u20131.35, 95% CI: \u20132.11, \u20130.58), and lower levels of forkhead box P3 (FoxP3) mRNA (HT: SMD=\u20132.58, 95% CI: \u20133.12, \u20132.05; GD: SMD=\u20132.13, 95% CI: \u20132.56, \u20131.70), compared to the healthy population. In addition, the single nucleotide polymorphism rs3761548 and rs3761549 in the promoter region of FoxP3 showed a higher frequency in the comparison of genotype \u201cCT\u201d only in HT patients than in the healthy population (OR=1.66, 95%CI: 1.18, 2.34). In patients with newly diagnosed AITD, the Th17\/Treg ratio imbalance may develop AITD. Monitoring Th17 and Treg levels may become an essential tool to assess the organism\u2019s immune homeostasis and hopefully guide clinical diagnosis and treatment.<\/jats:p>","DOI":"10.1055\/a-1972-5787","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T19:39:45Z","timestamp":1667590785000},"page":"40-50","source":"Crossref","is-referenced-by-count":7,"title":["Helper T Cell 17 and Regulatory T Cell Levels in Peripheral Blood of Newly Diagnosed Patients with Autoimmune Thyroid Disease: A Meta-Analysis"],"prefix":"10.1055","volume":"55","author":[{"given":"Aizhi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Putian First Hospital, Putian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Ganzhou People\u2019s Hospital, Ganzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.cyto.2019.01.003","article-title":"Immunological aspects of autoimmune thyroid disease \u2013 complex interplay between cells and cytokines","volume":"116","author":"J Luty","year":"2019","journal-title":"Cytokine"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/cei.12410","article-title":"Associations of single nucleotide polymorphisms in precursor-microRNA (miR)-125a and the expression of mature miR-125a with the development and prognosis of autoimmune thyroid diseases","volume":"178","author":"Y 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Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1972-5787.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T05:07:55Z","timestamp":1728277675000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1972-5787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,4]]},"references-count":46,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2023,1,4]]},"published-print":{"date-parts":[[2023,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1972-5787","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,11,4]]},"published":{"date-parts":[[2022,11,4]]}}}