{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:35:59Z","timestamp":1773203759699,"version":"3.50.1"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Patients with hemophilia (PWHs) suffer from an increased risk of osteoporosis. Multiple hemophilia and hemophilic arthropathy associated factors correlate with a low bone mineral density (BMD) in PWHs. The aim of this study was to assess the long-term development of BMD in PWH as well as to analyze potentially influencing factors.<\/jats:p><jats:p>\n          Methods\u2003A total of 33 adult PWHs were evaluated in a retrospective study. General medical history, specific-hemophilia-associated comorbidities, joint status using the Gilbert score, calcium level, and vitamin D level as well as at least two results of bone density measurements with a minimum range of 10 years per patient were taken into account.<\/jats:p><jats:p>\n          Results\u2003The BMD did not change significantly from one point of measurement to the other. A total of 7 (21.2%) cases of osteoporosis and 16 (48.5%) cases of osteopenia were identified. The two following significant correlations could be revealed: the higher the patients' body mass index, the higher their BMD (r\u2009=\u20090.41; p\u2009=\u20090.022). Moreover, a high Gilbert score came along with a low BMD (r\u2009=\u2009\u22120.546; p\u2009=\u20090.003).<\/jats:p><jats:p>\n          Conclusion\u2003Even if PWHs frequently suffer from a reduced BMD, our data suggest that their BMD remains constant on a low level in the course of time. A risk factor of osteoporosis often found in PWHs is a vitamin D deficiency and joint destruction. Therefore, a standardized screening of PWHs on BMD reduction by collecting vitamin D blood level and assessing joint status seems appropriate.<\/jats:p>","DOI":"10.1055\/a-1972-8983","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:01:55Z","timestamp":1677801715000},"page":"208-214","source":"Crossref","is-referenced-by-count":9,"title":["Osteoporosis Remains Constant in Patients with Hemophilia\u2014Long-Term Course in Consideration of Comorbidities"],"prefix":"10.1055","volume":"43","author":[{"given":"Anna C.","family":"Strauss","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pius","family":"Muellejans","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, University Hospital Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Koob","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, University Hospital Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Goldmann","sequence":"additional","affiliation":[{"name":"Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Pennekamp","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, University Hospital Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Wallny","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, University Hospital Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas C.","family":"Strauss","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, University Hospital Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1365-2516.2006.01405.x","article-title":"Osteoporosis in haemophilia - an underestimated comorbidity?","volume":"13","author":"T A Wallny","year":"2007","journal-title":"Haemophilia"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1160\/TH09-09-0629","article-title":"Bone mineral density in haemophilia patients. 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