{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:43:01Z","timestamp":1792100581607,"version":"4.4.0"},"reference-count":45,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002Concomitant hiatal hernia (HH) repair with transoral incisionless fundoplication (TIF) is a therapeutic option for patients with HH &gt;\u200a2\u200acm and gastroesophageal reflux disease (GERD). Data comparing this approach with laparoscopic Nissen fundoplication (LNF) are lacking. We performed an exploratory analysis to compare these two approaches' adverse events (AEs) and clinical outcomes.<\/jats:p><jats:p>\n          Patients and methods\u2002This was a multicenter retrospective cohort study of HH repair followed by LNF versus HH repair followed by TIF in patients with GERD and moderate HH (2\u20135\u200acm). AEs were assessed using the Clavien-Dindo classification. Symptoms (heartburn\/regurgitation, bloating, and dysphagia) were compared at 6 and 12 months.<\/jats:p><jats:p>\n          Results\u2002A total of 125 patients with HH repair with TIF and 70 with HH repair with LNF were compared. There was no difference in rates of discontinuing or decreasing proton pump inhibitor use, dysphagia, esophagitis, disrupted wrap, and HH recurrence between the two groups (P\u200a&gt;\u200a0.05). The length of hospital stay (1 day vs. 2 days), 30-day readmission rate (0 vs. 4.3\u200a%), early AE rate (0 vs. 18.6\u200a%), and early serious AE rate (0 vs. 4.3\u200a%) favored TIF (all P\u200a&lt;\u200a0.05). The rate of new or worse than baseline bloating was lower in the TIF group at 6 months (13.8\u200a% vs. 30.0\u200a%, P\u200a=\u200a0.009).<\/jats:p><jats:p>\n          Conclusions\u2002Concomitant HH repair with TIF is feasible and associated with lower early and serious AEs compared to LNF. Further comparative efficacy studies are warranted.<\/jats:p>","DOI":"10.1055\/a-1972-9190","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T23:49:20Z","timestamp":1672876160000},"page":"E11-E18","source":"Crossref","is-referenced-by-count":24,"title":["Hiatal hernia repair with transoral incisionless fundoplication versus Nissen fundoplication for gastroesophageal reflux disease: A retrospective study"],"prefix":"10.1055","volume":"11","author":[{"given":"Veeravich K.","family":"Jaruvongvanich","sequence":"additional","affiliation":[{"name":"Mayo Clinic \u2013 Gastroenterology and Hepatology, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Matar","sequence":"additional","affiliation":[{"name":"Mayo Clinic \u2013 Gastroenterology and Hepatology, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janani","family":"Reisenauer","sequence":"additional","affiliation":[{"name":"Mayo Clinic \u2013 Thoracic Surgery, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Janu","sequence":"additional","affiliation":[{"name":"Fox Valley Technical College, ThedaCare Regional Medical System, Appleton, Wisconsin, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mavrelis","sequence":"additional","affiliation":[{"name":"Methodist Hospitals Inc. \u2013 Surgery, Gary, Indiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Ihde","sequence":"additional","affiliation":[{"name":"Matagorda Regional Medical Center \u2013 Matagorda Medical Group, Bay City, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Murray","sequence":"additional","affiliation":[{"name":"UNRMed \u2013 University of Nevada, Reno, Nevada, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneha","family":"Singh","sequence":"additional","affiliation":[{"name":"Mayo Clinic \u2013 Gastroenterology and Hepatology, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Kolb","sequence":"additional","affiliation":[{"name":"UCIrvine \u2013 Gastroenterology, Irvine, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninh T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"UCIrvine \u2013 Surgery, Irvine, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirav","family":"Thosani","sequence":"additional","affiliation":[{"name":"University of Texas McGovern Medical School \u2013 Gastroenterology, Hepatology and Nutrition, Houston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik B.","family":"Wilson","sequence":"additional","affiliation":[{"name":"University of Texas McGovern Medical School \u2013 Surgery, Houston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasa","family":"Zarnegar","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College \u2013 Surgery, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Chang","sequence":"additional","affiliation":[{"name":"UCIrvine \u2013 Gastroenterology, Irvine, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia I.","family":"Canto","sequence":"additional","affiliation":[{"name":"Johns Hopkins Hospital and Health System \u2013 Gastroenterology, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barham K.","family":"Abu Dayyeh","sequence":"additional","affiliation":[{"name":"Mayo Clinic \u2013 Gastroenterology and Hepatology, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1136\/gutjnl-2012-304269","article-title":"Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review","volume":"63","author":"H B El-Serag","year":"2014","journal-title":"Gut"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1111\/j.1365-2036.2006.02952.x","article-title":"Gastro-oesophageal reflux symptoms and health-related quality of life in the adult general population--the Kalixanda study","volume":"23","author":"J Ronkainen","year":"2006","journal-title":"Aliment Pharmacol 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proceedings"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2147\/tcrm.2007.3.2.231","article-title":"Long-term management of gastroesophageal reflux disease with pantoprazole","volume":"3","author":"T Scholten","year":"2007","journal-title":"Ther Clin Risk Manag"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/j.1365-2036.2010.04406.x","article-title":"Systematic review: persistent reflux symptoms on proton pump inhibitor therapy in primary care and community studies","volume":"32","author":"H El-Serag","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1097\/MCG.0b013e31814b8fc2","article-title":"Esophageal acid exposure on proton pump inhibitors in unselected asymptomatic gastroesophageal reflux disease patients","volume":"42","author":"A Grigolon","year":"2008","journal-title":"J Clin Gastroenterol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1136\/gut.2007.145581","article-title":"Management of heartburn not responding to proton pump inhibitors","volume":"58","author":"R Fass","year":"2009","journal-title":"Gut"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1001\/archsurg.2010.81","article-title":"Five-year follow-up of a multicenter, double-blind randomized clinical trial of laparoscopic Nissen vs anterior 90 degrees partial fundoplication","volume":"145","author":"R S Nijjar","year":"2010","journal-title":"Arch Surg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/bjs.4933","article-title":"Short-term cost effectiveness and long-term cost analysis comparing laparoscopic Nissen fundoplication with proton-pump inhibitor maintenance for gastro-oesophageal reflux disease","volume":"92","author":"R Cookson","year":"2005","journal-title":"Br J 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Tian","year":"2015","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.gie.2019.05.028","article-title":"Endoscopic GERD therapy: a primer for the transoral incisionless fundoplication procedure","volume":"90","author":"F Bazerbachi","year":"2019","journal-title":"Gastrointest Endosc"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1177\/1553350618755214","article-title":"The TEMPO Trial at 5 Years: transoral fundoplication (tif 2.0) is safe, durable, and cost-effective","volume":"25","author":"K S Trad","year":"2018","journal-title":"Surg Innov"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.21614\/chirurgia.113.2.173","article-title":"Transoral incisionless fundoplication (TIF 2.0): a meta-analysis of three randomized, controlled clinical trials","volume":"113","author":"L Gerson","year":"2018","journal-title":"Chirurgia (Bucur)"},{"key":"ref18","first-page":"92","article-title":"Hiatal hernia and the treatment of acid-related disorders","volume":"3","author":"J E Pandolfino","year":"2007","journal-title":"Gastroenterol Hepatol (NY)"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1111\/j.1572-0241.2002.05902.x","article-title":"Hiatal hernia size, Barrett's length, and severity of acid reflux are all risk factors for esophageal adenocarcinoma","volume":"97","author":"B Avidan","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1111\/j.1572-0241.1999.01277.x","article-title":"Barrett's esophagus: prevalence and size of hiatal hernia","volume":"94","author":"A J Cameron","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1111\/j.1572-0241.2001.03926.x","article-title":"Hiatal hernia size is the dominant determinant of esophagitis presence and severity in gastroesophageal reflux disease","volume":"96","author":"M P Jones","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.amjsurg.2011.06.035","article-title":"Short-term safety and symptomatic outcomes of transoral incisionless fundoplication with or without hiatal hernia repair in patients with chronic gastroesophageal reflux disease","volume":"202","author":"G M Ihde","year":"2011","journal-title":"Am J Surgery"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e2015.00104","DOI":"10.4293\/JSLS.2015.00104","article-title":"Laparoscopic hiatal hernia repair in 221 patients: outcomes and experience","volume":"20","author":"C G Chang","year":"2016","journal-title":"JSLS"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1177\/1553350619869449","article-title":"Laparoscopic hiatal hernia repair followed by transoral incisionless fundoplication with EsophyX device (HH + TIF): efficacy and safety in two community hospitals","volume":"26","author":"P Janu","year":"2019","journal-title":"Surg Innov"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00464-020-07796-x","article-title":"Efficacy and patient satisfaction of single-session transoral incisionless fundoplication and laparoscopic hernia repair","volume":"35","author":"C Gisi","year":"2020","journal-title":"Surg Endosc"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e2018.00087","DOI":"10.4293\/JSLS.2018.00087","article-title":"pH scores in hiatal repair with transoral incisionless fundoplication","volume":"23","author":"G M  Ihde 2nd","year":"2019","journal-title":"JSLS"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1007\/s00464-010-1267-8","article-title":"Guidelines for surgical treatment of gastroesophageal reflux disease","volume":"24","author":"D Stefanidis","year":"2010","journal-title":"Surg Endosc"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1007\/s00464-010-1528-6","article-title":"Transoral rotational esophagogastric fundoplication: technical, anatomical, and safety considerations","volume":"25","author":"R C Bell","year":"2011","journal-title":"Surg Endosc"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/SLA.0b013e31817c9630","article-title":"Transoral endoscopic fundoplication in the treatment of gastroesophageal reflux disease: the anatomic and physiologic basis for reconstruction of the esophagogastric junction using a novel device","volume":"248","author":"B A Jobe","year":"2008","journal-title":"Ann Surg"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"D Dindo","year":"2004","journal-title":"Ann Surg"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"AB254","DOI":"10.1016\/j.gie.2018.04.454","article-title":"Efficacy of combined transoral incisionless fundoplication and laparaoscopic hiatal hernia repair","volume":"87","author":"K Wang","year":"2018","journal-title":"Gastrointest Endosc"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1365-2036.2011.04677.x","article-title":"Reflux parameters as modified by EsophyX or laparoscopic fundoplication in refractory GERD","volume":"34","author":"M Frazzoni","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1053\/j.gastro.2017.12.021","article-title":"Efficacy of laparoscopic nissen fundoplication vs transoral incisionless fundoplication or proton pump inhibitors in patients with gastroesophageal reflux disease: a systematic review and network meta-analysis","volume":"154","author":"J E Richter","year":"2018","journal-title":"Gastroenterology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1053\/j.gastro.2018.02.042","article-title":"Efficacy of laparoscopic Nissen fundoplication vs transoral incisionless fundoplication or proton pump inhibitors in patients with gastroesophageal reflux disease: misleading ranking probabilities in network meta-analysis","volume":"155","author":"B Abu Dayyeh","year":"2018","journal-title":"Gastroenterology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1111\/apt.13427","article-title":"Randomised clinical trial: transoral incisionless fundoplication vs. sham intervention to control chronic GERD","volume":"42","author":"B Hakansson","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1053\/j.gastro.2014.10.009","article-title":"Efficacy of transoral fundoplication vs omeprazole for treatment of regurgitation in a randomized controlled trial","volume":"148","author":"J G Hunter","year":"2015","journal-title":"Gastroenterology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/ajg.2015.28","article-title":"Randomized controlled trial of transoral incisionless fundoplication vs. proton pump inhibitors for treatment of gastroesophageal reflux disease","volume":"110","author":"B P Witteman","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1007\/s00464-018-6403-x","article-title":"Long-term reported outcomes of transoral incisionless fundoplication: an 8-year cohort study","volume":"33","author":"M Chimukangara","year":"2019","journal-title":"Surg Endosc"},{"key":"ref39","first-page":"1","article-title":"Long-term benefit of transoral incisionless fundoplication using the esophyx device for the management of gastroesophageal reflux disease responsive to medical therapy","volume":"30","author":"G Stefanidis","year":"2017","journal-title":"Dis Esophagus"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1007\/s00464-014-4008-6","article-title":"Long-term efficacy of transoral incisionless fundoplication with Esophyx (Tif 2.0) and factors affecting outcomes in GERD patients followed for up to 6 years: a prospective single-center study","volume":"29","author":"P A Testoni","year":"2015","journal-title":"Surg Endosc"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12876-016-0502-8","article-title":"A meta-analysis of long follow-up outcomes of laparoscopic Nissen (total) versus Toupet (270 degrees ) fundoplication for gastro-esophageal reflux disease based on randomized controlled trials in adults","volume":"16","author":"X Du","year":"2016","journal-title":"BMC Gastroenterol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s11605-009-0873-z","article-title":"Surgical reintervention after failed antireflux surgery: a systematic review of the literature","volume":"13","author":"E J Furnee","year":"2009","journal-title":"J Gastrointest Surg"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"17115","DOI":"10.3748\/wjg.v20.i45.17115","article-title":"Revision of failed transoral incisionless fundoplication by subsequent laparoscopic Nissen fundoplication","volume":"20","author":"A Ashfaq","year":"2014","journal-title":"World J Gastroenterol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1007\/s00464-014-3897-8","article-title":"Laparoscopic anti-reflux revision surgery after transoral incisionless fundoplication is safe and effective","volume":"29","author":"R C Bell","year":"2015","journal-title":"Surg 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