{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T23:30:57Z","timestamp":1717025457707},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuklearmedizin"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose To compare bone marrow biopsy (BMB) with [18F]-fluoro-2-deoxy-d-glucose positron emission tomography\/computed tomography (PET\/CT) imaging in the demonstration of bone marrow involvement in children with Hodgkin\u2019s Lymphoma (HL) and to investigate the effectiveness of PET\/CT imaging and thus the necessity for BMB at staging.<\/jats:p><jats:p>\n          Methods Pediatric patients with HL, who underwent both bilateral iliac BMB and PET\/CT imaging at disease staging were retrospectively analyzed. In determining bone marrow involvement (BMinv), BMB and\/or first\/follow-up PET\/CT imaging were eligible for review.<\/jats:p><jats:p>\n          Results Fifty-six patients were included. BMinv was detected by PET\/CT imaging in 6\/56 (10.7%), whereas the proportion was 3\/56 (5.3%) in BMB specimens. Bone marrow biopsies and PET\/CT images were concordant in 53\/56 (94.6%) patients with BMB specimens missing three cases of BMinv detected by PET\/CT. When diagnostic accuracy was calculated, sensitivity, specificity, positive predictive value and negative predictive values for PET\/CT were 100%, 100%, 100%, 100%, respectively, and the same values for BMB were 50%, 100%, 100%, 94.3%, respectively.<\/jats:p><jats:p>\n          Conclusions The results of PET\/CT and BMB for staging of pediatric HL patients were compatible, and PET\/CT imaging was found to provide high diagnostic performance in determining BMinv. In keeping with earlier research, the current study showed that BMB may not be necessary in every patient at staging, and should be reserved for cases where PET\/CT is inconclusive.<\/jats:p>","DOI":"10.1055\/a-1972-9292","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T23:37:38Z","timestamp":1675726658000},"page":"20-26","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of bone marrow biopsy and fluorodeoxyglucose-positron emission tomography for the assessment of bone marrow infiltration in children with Hodgkin\u2019s lymphoma"],"prefix":"10.1055","volume":"62","author":[{"given":"Esra","family":"Arslanta\u015f","sequence":"additional","affiliation":[{"name":"pediatric hematology oncology, Ba\u015fak\u015fehir \u00c7am ve Sakura \u015eehir Hastanesi, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ay\u00e7i\u00e7ek","sequence":"additional","affiliation":[{"name":"pediatric hematology oncology, Ba\u015fak\u015fehir \u00c7am ve Sakura \u015eehir Hastanesi, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferhan","family":"Ak\u0131c\u0131","sequence":"additional","affiliation":[{"name":"pediatric hematology oncology, \u0130stanbul Kanuni Sultan S\u00fcleyman E\u011fitim ve Ara\u015ft\u0131rma Hastanesi, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selvinaz","family":"\u00d6zkara","sequence":"additional","affiliation":[{"name":"Pathology, Ba\u015fak\u015fehir \u00c7am ve Sakura \u015eehir Hastanesi, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bur\u00e7ak","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, Ba\u015fak\u015fehir \u00c7am ve Sakura \u015eehir Hastanesi, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihal","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"pediatric hematology oncology, Istinye Universitesi, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cengiz","family":"Bayram","sequence":"additional","affiliation":[{"name":"pediatric hematology oncology, Ba\u015fak\u015fehir \u00c7am ve Sakura \u015eehir Hastanesi, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"ref1","first-page":"459","volume-title":"Hodgkin Lymphoma","author":"CM Smith","year":"2021"},{"issue":"01","key":"ref2","doi-asserted-by":"publisher","first-page":"e49","DOI":"10.1016\/S2352-3026(21)00349-5","article-title":"Survival by age in paediatric and adolescent patients with Hodgkin lymphoma: a retrospective pooled analysis of children\u2019s oncology group 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