{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:21Z","timestamp":1740126861057,"version":"3.37.3"},"reference-count":13,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund Das Mantelzelllymphom (MCL) stellt eine seltene Subklasse der Non-Hodgkin-Lymphome dar.<\/jats:p><jats:p>\n          Ziel Darstellung des immunhistochemischen und molekulargenetischen Profils von 3 verschiedenen F\u00e4llen dieses seltenen Krankheitsbildes der Glandula lacrimalis (GL).<\/jats:p><jats:p>\n          Material und Methoden Monozentrische, retrospektive Fallserie von Patienten mit histopathologisch gesichertem MCL der GL.<\/jats:p><jats:p>\n          Ergebnisse Es werden 3 F\u00e4lle pr\u00e4sentiert: MCL mit isoliertem Befall der GL, MCL der GL als erstes Zeichen der systemischen Beteiligung und als Erstsymptom eines systemischen\n\t\t\t\t\tMCL-Rezidivs. Alle Patienten wiesen folgenden Immunph\u00e4notyp auf: CD19- und CD20-positiv sowie CD10- und CD23-negativ. Nur ein MCL zeigte sich CD5-negativ. Die \u00dcberexpression von Cyclin D1\n\t\t\t\t\tals Konsequenz des pathologischen Karyotyps mit Translokation t(11;14) (q13;q32) in der Fluoreszenz-in-situ-Hybridisierung wurde bei allen Patienten beobachtet. \u00c4hnlich zeigten alle F\u00e4lle\n\t\t\t\t\tdie erh\u00f6hte Expression von B-Zell-Lymphom-Protein 2 (BCL-2) sowie SRY-Box-transkribierendem Faktor 11 (SOX-11).<\/jats:p><jats:p>\n          Schlussfolgerung Das immunhistochemische Profil der betroffenen GL stimmte mit dem klassischen MCL-Profil \u00fcberein. Bioptisch zeigten sich alle 3 F\u00e4lle auf die Target-Molek\u00fcle der\n\t\t\t\t\tzurzeit zugelassenen zielgerichteten Therapien positiv (CD20 f\u00fcr Rituximab bzw. BCL-2 f\u00fcr die Bruton-Kinase-Inhibitoren und CD19 f\u00fcr die chim\u00e4re Antigenrezeptor-T-Zell-Therapie\n\t\t\t\t\t[CAR-T-Therapie]). Somit ist aus okuloplastischer Sicht eine inzisionale Biopsie zur Histologiegewinnung das Vorgehen der Wahl.<\/jats:p>","DOI":"10.1055\/a-1973-0492","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T23:45:45Z","timestamp":1674863145000},"page":"33-38","source":"Crossref","is-referenced-by-count":1,"title":["Immunhistochemisches und molekulargenetisches Profil von Mantelzelllymphomen der Glandula lacrimalis: eine detaillierte Beschreibung einer seltenen Tumorentit\u00e4t der\n\t\t\t\t\tTr\u00e4nendr\u00fcse"],"prefix":"10.1055","volume":"240","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8323-7107","authenticated-orcid":false,"given":"Luca","family":"Mautone","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Hamburg-Eppendorf, Hamburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Dierlamm","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Onkologie, II. Medizinische Klinik und Poliklinik, Universit\u00e4tsklinikum Hamburg-Eppendorf, Hamburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Christine","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Diagnostik, Institut f\u00fcr Pathologie mit den Sektionen Molekularpathologie und Zytopathologie, Universit\u00e4tsklinikum Hamburg-Eppendorf, Hamburg,\n\t\t\t\t\tDeutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Viehweger","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Diagnostik, Institut f\u00fcr Pathologie mit den Sektionen Molekularpathologie und Zytopathologie, Universit\u00e4tsklinikum Hamburg-Eppendorf, Hamburg,\n\t\t\t\t\tDeutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hansj\u00f6rg","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Diagnostik, Institut f\u00fcr Pathologie mit den Sektionen Molekularpathologie und Zytopathologie, Universit\u00e4tsklinikum Hamburg-Eppendorf, Hamburg,\n\t\t\t\t\tDeutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Sch\u00fcttauf","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Hamburg-Eppendorf, Hamburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Green","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Hamburg-Eppendorf, Hamburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Dulz","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Hamburg-Eppendorf, Hamburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1097\/01.pas.0000213350.49767.46","article-title":"Lymphoma of the ocular adnexa: A study of 353 cases","volume":"31","author":"J A Ferry","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1001\/jamaophthalmol.2017.4810","article-title":"Clinicopathological Features of Ocular Adnexal Mantle-Cell Lymphoma in an International Multicenter Cohort","volume":"135","author":"M KH Knudsen","year":"2017","journal-title":"JAMA Ophthalmol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.ophtha.2004.07.025","article-title":"Mantle cell lymphoma in the ocular adnexal region","volume":"112","author":"A Looi","year":"2005","journal-title":"Ophthalmology"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1056\/NEJMoa1306220","article-title":"Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma","volume":"369","author":"M L Wang","year":"2013","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1200\/JCO.19.01294","article-title":"Treatment of Older Patients With Mantle Cell Lymphoma (MCL): Long-Term Follow-Up of the Randomized European MCL Elderly Trial","volume":"38","author":"H C Kluin-Nelemans","year":"2020","journal-title":"J Clin Oncol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1111\/bjh.14870","article-title":"Outcomes in 370 patients with mantle cell lymphoma treated with ibrutinib: a pooled analysis from three open-label studies","volume":"179","author":"S Rule","year":"2017","journal-title":"Br J Haematol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/S0140-6736(17)33108-2","article-title":"Acalabrutinib in relapsed or refractory mantle cell lymphoma (ACE-LY-004): a single-arm, multicentre, phase 2 trial","volume":"391","author":"M Wang","year":"2018","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1056\/NEJMoa1715519","article-title":"Ibrutinib plus Venetoclax for the Treatment of Mantle-Cell Lymphoma","volume":"378","author":"C S Tam","year":"2018","journal-title":"N Engl J Med"},{"issue":"14","key":"ref10","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1056\/NEJMoa1914347","article-title":"KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma","volume":"382","author":"M Wang","year":"2020","journal-title":"N Engl J Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1002\/ajh.25487","article-title":"Mantle cell lymphoma: 2019 update on the diagnosis, pathogenesis, prognostication, and management","volume":"94","author":"P Jain","year":"2019","journal-title":"Am J Hematol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1097\/PAS.0000000000001278","article-title":"CD5-negative Mantle Cell Lymphoma: Clinicopathologic Correlations and Outcome in 58 Patients","volume":"43","author":"Y Miao","year":"2019","journal-title":"Am J Surg Pathol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1200\/JCO.2015.63.8387","article-title":"Prognostic Value of Ki-67 Index, Cytology, and Growth Pattern in Mantle-Cell Lymphoma: Results From Randomized Trials of the European Mantle Cell Lymphoma Network","volume":"34","author":"E Hoster","year":"2016","journal-title":"J Clin Oncol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1200\/JCO.19.01294","article-title":"Treatment of Older Patients With Mantle Cell Lymphoma (MCL): Long-Term Follow-Up of the Randomized European MCL Elderly Trial","volume":"38","author":"H C Kluin-Nelemans","year":"2020","journal-title":"J Clin Oncol"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1973-0492.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T09:13:35Z","timestamp":1676020415000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1973-0492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":13,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2023,1,27]]},"published-print":{"date-parts":[[2023,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1973-0492","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"type":"print","value":"0023-2165"},{"type":"electronic","value":"1439-3999"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}