{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T19:27:11Z","timestamp":1759778831629},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Malaria is one of the world\u2019s most devastating diseases, infecting well\n                    over 300 million people annually and killing between 2 and 3 million worldwide.\n                    Increasing parasite resistance to many existing drugs is exacerbating disease.\n                    Resistance to commonly used malarial drugs is increasing the need to develop new\n                    drugs urgently. Due to the slow pace and substantial costs of new drug\n                    development, repurposing of old drugs which is recently increasingly becoming an\n                    attractive proposition of highly efficient and effective way of drug discovery\n                    led us to study the drug rifampicin for this purpose. The present paper aims to\n                    investigate the route of Plasmodium falciparum apicoplast-targeted\n                    proteins that putatively encode \u03b2 subunits of RNA polymerase with an\n                    objective to develop an effective antimalarial drug. Homology searching for\n                    conserved binding site to the rifampicin drug and the functional analysis of\n                        rpoB gene were done. Multiple Sequence alignment analysis of\n                        rpoB was compared with that in E.coli \u2013 rpoB\n                    and M. tuberculosis \u2013 rpoB. Docking studies of\n                        Rifampicin \u2013 rpoB complex was also done for finding\n                    binding affinity. The results of computational studies showed that rifampicin is\n                    a potential drug for malaria.<\/jats:p>","DOI":"10.1055\/a-1974-9028","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:32:02Z","timestamp":1673310722000},"page":"164-169","source":"Crossref","is-referenced-by-count":5,"title":["Molecular Docking Studies of Rifampicin \u2013 rpoB\n                    complex: Repurposing Drug Design Implications for against Plasmodium\n                        falciparum Malaria through a Computational Approach"],"prefix":"10.1055","volume":"73","author":[{"given":"Upasana","family":"Yadav","sequence":"additional","affiliation":[{"name":"Amity School of Applied Sciences Lucknow, Amity University Uttar\n                    Pradesh, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaya","family":"Pandey","sequence":"additional","affiliation":[{"name":"Amity School of Applied Sciences Lucknow, Amity University Uttar\n                    Pradesh, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/s1286-4579(01)01524-6.","article-title":"Mechanisms of resistance of Plasmodium falciparum to antimalarial drugs","volume":"4","author":"J E Hyde","year":"2002","journal-title":"Microbes Infect"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107672","author":"Z N Lei","year":"2020","journal-title":"Chloroquine and hydroxychloroquine in the treatment of malaria and\n                    repurposing in treating COVID-19 pharmthera"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/open.202200064","article-title":"Meunier B. 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