{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:12:35Z","timestamp":1788448355490,"version":"build-2803163510"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background Ischemia\/reperfusion has been reported to further\n                    damage the intestine reperfusion injury (IRI) and cause multiple distal organ\n                    dysfunction through oxidative stress, inflammation, and apoptosis. Cysteamine is\n                    known to inhibit oxidative stress, inflammatory cytokines and apoptosis. This\n                    experiment was designed to evaluate the role of cysteamine against IRI in\n                    rats<\/jats:p><jats:p>\n          Methods Thirty-two Wistar rat strains were assigned to four groups: sham,\n                    Intestinal-reperfusion injury (IRI), 50\u2009mg\/kg and\n                    100\u2009mg\/kg cysteamine treatment IRI. A 5\u2009cm segment of\n                    terminal ileum was twisted 360\u00b0 clockwise along the mesentery for\n                    45\u2009minutes to induce ischemia before detorsion. Tissues were preserved\n                    for biochemical evaluation and histology 4\u2009hours after detorsion.\n                    Activities of GPx, GSH, protein and non-protein thiol,\n                        H2O2, MDA were evaluated. Serum concentration of\n                    nitrite, MPO, ALT, AST TNF-alpha and IL-6 were measured. Caspase 3 and bax were\n                    evaluated by immunohistochemistry. Statistical significance was set as\n                    p&lt;0.05<\/jats:p><jats:p>\n          Results Significant (p&lt;0.05) increase in\n                        H2O2, MDA and nitrite but reduction in GPx, GSH,\n                    protein thiol and non-protein thiol in the IRI rats was reversed by 50 and\n                    100\u2009mg\/kg cysteamine. Serum MPO, TNF-\u03b1, IL6, AST and ALT\n                    was significantly elevated in IRI while the rats treated with cysteamine showed\n                    a significant decrease (p&lt;0.05) in the activities of these inflammatory\n                    and hepatic injury markers.<\/jats:p><jats:p>\n          Conclusion Cysteamine mitigate IRI by enhancing intracellular antioxidant\n                    defense system, inhibiting inflammatory mediators and intestinal tissue\n                    expression of pro-apoptotic protein.<\/jats:p>","DOI":"10.1055\/a-1974-9132","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T23:36:36Z","timestamp":1672184196000},"page":"137-145","source":"Crossref","is-referenced-by-count":8,"title":["Cysteamine Attenuate Intestinal Reperfusion Injury Induced by\n                    Occlusion of Mesenteric Artery by Enhancing Intracellular Thiol\n                    Activities"],"prefix":"10.1055","volume":"73","author":[{"given":"Babatunde","family":"Alabi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Therapeutics, Faculty of Basic\n                    Clinical Sciences, Bowen University, Osun State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olugbenga","family":"Iwalewa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Basic Medical\n                    Sciences, College of Medicine, University of Ibadan, Ibadan,\n                    Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temidayo","family":"Omobowale","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Ibadan,\n                    Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeolu","family":"Adedapo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology & Toxicology, University\n                    of Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Opeyemi","family":"Hammed","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Basic Medical Science, Ladoke\n                    Akintola University of Technology, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Ajike","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Basic Medical Science, Ladoke\n                    Akintola University of Technology, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oladele","family":"Afolabi","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Basic Medical Science, Ladoke\n                    Akintola University of Technology, 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