{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:47:37Z","timestamp":1777927657150,"version":"3.51.4"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003Our objective was to determine whether resolution of a low-lying placenta or placenta previa is associated with postpartum hemorrhage (PPH).<\/jats:p><jats:p>\n            Study Design\u2003This is a retrospective, matched-control cohort study of women who underwent transvaginal sonography during fetal anatomic survey between 18 and 24 weeks of gestation at the University of Pennsylvania from January 2017 to May 2019. Exposure was defined as low-lying placenta (\u22641\u2009cm from the internal cervical os) or placenta previa (covering the os) at anatomic survey that was found to be resolved by transvaginal ultrasound in the third trimester. For each exposure, we identified a control patient whose placenta was\u2009&gt;\u20091\u2009cm from internal os at anatomic survey performed on the same day. The primary outcome was PPH at delivery, defined as estimated blood loss \u2265 1,000\u2009mL.<\/jats:p><jats:p>\n            Results\u2003A total of 450 women were included (225\/group). The exposed group of resolved placental previa included 85.0% with resolved low-lying placenta and 15.0% with resolved previa. The rate of PPH was significantly higher in the exposed group versus controls (9.8% vs. 4.4%, p\u2009=\u20090.03). Women with resolved previa were 2.5 times more likely to experience PPH than controls (adjusted odds ratio\u2009=\u20092.58, 95% confidence interval: 1.17\u20135.69), even when controlling for parity, prior cesarean, and delivery mode. Women with resolved previa were also more likely to present to triage with bleeding (16.4% vs. 8.0%, p\u2009=\u20090.006), receive antenatal corticosteroids, (9.3% vs. 3.1%, p\u2009=\u20090.006), and receive intravenous iron postpartum (7.6% vs. 3.1%, p\u2009=\u20090.04).<\/jats:p><jats:p>\n            Conclusion\u2003Our data demonstrate that women with a resolved low-lying placenta or placenta previa remain at significantly increased risk of bleeding-related complications in pregnancy and during delivery when compared with those who never had a previa. Clinicians should consider this association when counseling patients and performing hemorrhage risk stratification.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1974-9399","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T23:59:02Z","timestamp":1668038342000},"page":"e928-e933","source":"Crossref","is-referenced-by-count":7,"special_numbering":"S","title":["A Resolved Placenta Previa Is Still Associated with Postpartum Hemorrhage"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0823-6005","authenticated-orcid":false,"given":"Sun Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Women's Health, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca F.","family":"Hamm","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal and Child Health Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadav","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal and Child Health Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"issue":"05","key":"ref2","first-page":"503","article-title":"Assessing reVITALize: should the definition of postpartum hemorrhage differ by mode of delivery?","volume":"34","author":"R F Hamm","year":"2017","journal-title":"Am J Perinatol"},{"issue":"09","key":"ref3","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1055\/s-0031-1280853","article-title":"Placenta previa in the second trimester: sonographic and clinical factors associated with its resolution","volume":"28","author":"K Y Eichelberger","year":"2011","journal-title":"Am J Perinatol"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1055\/s-2000-9269","article-title":"Maternal complications with placenta previa","volume":"17","author":"J M Crane","year":"2000","journal-title":"Am J Perinatol"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.jp.7211621","article-title":"Second trimester placental location as a predictor of an adverse pregnancy outcome","volume":"27","author":"E F Magann","year":"2007","journal-title":"J Perinatol"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0020-7292(03)00211-X","article-title":"Obstetric implications of low-lying placentas diagnosed in the second trimester","volume":"83","author":"O Ogueh","year":"2003","journal-title":"Int J Gynaecol Obstet"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"631","DOI":"10.7863\/jum.2013.32.4.631","article-title":"Second-trimester placental location and postpartum hemorrhage","volume":"32","author":"S S Osmundson","year":"2013","journal-title":"J Ultrasound Med"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1097\/AOG.0000000000002351","article-title":"183: postpartum hemorrhage","volume":"130","author":"Committee on Practice Bulletins-Obstetrics","year":"2017","journal-title":"Obstet Gynecol"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1097\/AOG.0000000000000129","article-title":"Transabdominal ultrasonography as a screening test for second-trimester placenta previa","volume":"123","author":"H S Quant","year":"2014","journal-title":"Obstet Gynecol"},{"issue":"03","key":"ref12","doi-asserted-by":"crossref","first-page":"266.e1","DOI":"10.1016\/j.ajog.2009.06.009","article-title":"Placenta previa: distance to internal os and mode of delivery","volume":"201","author":"P Vergani","year":"2009","journal-title":"Am J Obstet Gynecol"},{"issue":"02","key":"ref13","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/AOG.0000000000004228","article-title":"Risk factors for atonic postpartum hemorrhage: a systematic review and meta-analysis","volume":"137","author":"H B Ende","year":"2021","journal-title":"Obstet Gynecol"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1974-9399.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:17:55Z","timestamp":1730812675000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1974-9399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,9]]},"references-count":10,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1974-9399","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,11,9]]},"published":{"date-parts":[[2022,11,9]]}}}