{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:18:13Z","timestamp":1774264693316,"version":"3.50.1"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose To quantify microvascular vessel density in the optic disc using optical coherence tomography angiography (OCTA) in patients with systemic sclerosis (SS); to determine\n          whether there is a difference in values between patients and controls; and to correlate the OCTA measurements with disease activity, damage risk, and drug usage.<\/jats:p><jats:p>\n          Methods Patients aged 20\u200a\u2013\u200a76 years who were followed up after a diagnosis of SS and age- and gender-matched controls. The patients underwent RTVue-XR AngioVue OCTA imaging in this\n          cross-sectional observational study.<\/jats:p><jats:p>\n          Results A total of 61 eyes of 61 consecutive SS patients and 60 eyes of 60 controls were investigated. There was no statistically significant difference between the patients and\n          control groups regarding the average RNFL (retinal fiber layer) and radial peripapillary capillary (RPC) vessel density (VD) measurements (p\u2009=\u20090.35, p\u2009=\u20090.25, respectively). As the\n          antinuclear antibody (ANA) titer increased, RNFLsuperior (p\u2009=\u20090.01, r\u2009=\u2009\u2212\u20090.327), RPCwhole (p\u2009=\u20090.029, r\u2009=\u20090.279), RPCperipapillary (p\u2009=\u20090.037, r\u2009=\u2009\u2212\u20090.267), RPCsuperior (p\u2009=\u20090.003,\n          r\u2009=\u2009\u2212\u20090.371), and RPCinferior (p\u2009=\u20090.02, r\u2009=\u20090.297) values decreased with statistical significance. The RPCinside values were lower in anti-Scl-70-positive patients compared to patients\n          negative for anti-Scl-70 (topoisomerase I) (p\u2009=\u20090.021). The RNFLnasal (p\u2009=\u20090.03, r\u2009=\u2009\u2212\u20090.278) value decreased as the years of disease increased. The RPCinside value was higher in patients\n          using hydroxychloroquine and calcium channel blockers than those who did not use them (p\u2009=\u20090.021 and p\u2009=\u20090.027, respectively). The RPCwhole, RPCperipapillary, and RPCnasal values were\n          higher, with statistical significance in corticosteroid users than in those patients who did not use corticosteroids (p\u2009=\u20090.043, 0.030, and 0.033, respectively).<\/jats:p><jats:p>\n          Conclusion There was no significant difference between the patients and control groups regarding the average RPC VD measurements. However, since this is the first study to analyze\n          optic disc vessel density in SS patients, optic nerve blood flow changes in scleroderma with OCTA could be studied.<\/jats:p>","DOI":"10.1055\/a-1975-2222","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:20:37Z","timestamp":1668039637000},"page":"1277-1283","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Optic Nerve Head Using Optical Coherence Tomography Angiography in Systemic Sclerosis Patients"],"prefix":"10.1055","volume":"240","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1375-6643","authenticated-orcid":false,"given":"Sibel","family":"Zirtiloglu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Istanbul Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Suat","family":"Alikma","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Denizli State Hospital, Denizli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4424-2215","authenticated-orcid":false,"given":"Ozge Pinar Akarsu","family":"Acar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Istanbul Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"G\u00fcven","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Istanbul Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozan Cemal","family":"Icacan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Istanbul Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadime Ulviye","family":"Yigit","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Istanbul Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"530","DOI":"10.12968\/hmed.2019.80.9.530","article-title":"Systemic sclerosis","volume":"80","author":"M Hughes","year":"2019","journal-title":"Br J Hosp Med (Lond)"},{"key":"ref2","first-page":"251","article-title":"Is there an association between glaucoma and capillaroscopy in patients with systemic sclerosis?","volume":"38","author":"B F Gomes","year":"2018","journal-title":"Int Ophthalmol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.autrev.2017.05.024","article-title":"*The role of endothelial cells in 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